A first new antimalarial pregnane glycoside from Gongronema napalense

Amey Libman; Hongjie Zhang; Cuiying Ma; Bounhong Southavong; Kongmany Sydara; Somsanith Bouamanivong; Ghee T. Tan; Harry H. S. Fong; D. Doel Soejarto

A first new antimalarial pregnane glycoside from Gongronema napalense

Amey Libman, Hongjie Zhang, Cuiying Ma, Bounhong Southavong, Kongmany Sydara, Somsanith Bouamanivong, Ghee T. Tan, Harry H. S. Fong, D. Doel Soejarto

Chinese Medicine - Teaching and Research Division

Research output: Contribution to journal › Journal article

Abstract

As a part of the UIC-based ICBG project in Laos, plants were collected based on ethnomedical interviews and evaluated for antimalarial activity. A CHCl3 extract from the vine of Gongronema napalense (Wall.) Decne. (Asclepiadaceae) showed promising anti-malarial activity while exhibiting low levels of cytotoxicity and was thus followed up with further fractionation and biological evaluation. Bioassay-guided fractionation led to the isolation of a new steroidal glycoside, gongroneside A, which showed antimalarial activity in vitro with an IC50 value of 1.60 and 1.39 μM against the Plasmodium falciparum D6 and W2 clones, respectively.

Original language	English
Pages (from-to)	203-210
Number of pages	8
Journal	Asian Journal of Traditional Medicines
Volume	3
Issue number	6
Publication status	Published - Dec 2008

User-Defined Keywords

Gongronema napalense
asclepiadaceae
steroid glycoside
gongroneside A
Plasmodium falciparum
antimalarial activity

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http://asianjtm.syphu.edu.cn/CN/Y2008/V3/I6/203

Cite this

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title = "A first new antimalarial pregnane glycoside from Gongronema napalense",

abstract = "As a part of the UIC-based ICBG project in Laos, plants were collected based on ethnomedical interviews and evaluated for antimalarial activity. A CHCl3 extract from the vine of Gongronema napalense (Wall.) Decne. (Asclepiadaceae) showed promising anti-malarial activity while exhibiting low levels of cytotoxicity and was thus followed up with further fractionation and biological evaluation. Bioassay-guided fractionation led to the isolation of a new steroidal glycoside, gongroneside A, which showed antimalarial activity in vitro with an IC50 value of 1.60 and 1.39 μM against the Plasmodium falciparum D6 and W2 clones, respectively.",

keywords = "Gongronema napalense, asclepiadaceae, steroid glycoside, gongroneside A, Plasmodium falciparum, antimalarial activity",

author = "Amey Libman and Hongjie Zhang and Cuiying Ma and Bounhong Southavong and Kongmany Sydara and Somsanith Bouamanivong and Tan, {Ghee T.} and Fong, {Harry H. S.} and Soejarto, {D. Doel}",

year = "2008",

month = dec,

language = "English",

volume = "3",

pages = "203--210",

journal = "Asian Journal of Traditional Medicines",

issn = "1817-4337",

publisher = "Hong Kong Shengjing Pharmaceutical Publishing & Media Co., Limited",

number = "6",

}

TY - JOUR

T1 - A first new antimalarial pregnane glycoside from Gongronema napalense

AU - Libman, Amey

AU - Zhang, Hongjie

AU - Ma, Cuiying

AU - Southavong, Bounhong

AU - Sydara, Kongmany

AU - Bouamanivong, Somsanith

AU - Tan, Ghee T.

AU - Fong, Harry H. S.

AU - Soejarto, D. Doel

PY - 2008/12

Y1 - 2008/12

N2 - As a part of the UIC-based ICBG project in Laos, plants were collected based on ethnomedical interviews and evaluated for antimalarial activity. A CHCl3 extract from the vine of Gongronema napalense (Wall.) Decne. (Asclepiadaceae) showed promising anti-malarial activity while exhibiting low levels of cytotoxicity and was thus followed up with further fractionation and biological evaluation. Bioassay-guided fractionation led to the isolation of a new steroidal glycoside, gongroneside A, which showed antimalarial activity in vitro with an IC50 value of 1.60 and 1.39 μM against the Plasmodium falciparum D6 and W2 clones, respectively.

AB - As a part of the UIC-based ICBG project in Laos, plants were collected based on ethnomedical interviews and evaluated for antimalarial activity. A CHCl3 extract from the vine of Gongronema napalense (Wall.) Decne. (Asclepiadaceae) showed promising anti-malarial activity while exhibiting low levels of cytotoxicity and was thus followed up with further fractionation and biological evaluation. Bioassay-guided fractionation led to the isolation of a new steroidal glycoside, gongroneside A, which showed antimalarial activity in vitro with an IC50 value of 1.60 and 1.39 μM against the Plasmodium falciparum D6 and W2 clones, respectively.

KW - Gongronema napalense

KW - asclepiadaceae

KW - steroid glycoside

KW - gongroneside A

KW - Plasmodium falciparum

KW - antimalarial activity

M3 - Journal article

SN - 1817-4337

VL - 3

SP - 203

EP - 210

JO - Asian Journal of Traditional Medicines

JF - Asian Journal of Traditional Medicines

IS - 6

ER -

A first new antimalarial pregnane glycoside from Gongronema napalense

Abstract

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