A fast detection of peroxynitrite in living cells

Minglu Li, Xiaojuan Gong, Hung Wing Li, Hui Han, Shaomin Shuang, Shengmei Song*, Chuan Dong

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

Peroxynitrite (ONOO) plays a crucial role in the regulation of diverse pathophysiological processes, and high level of ONOO is profound association with numerous diseases. Herein, we developed an anthraquinone-based fluorescent probe L for ONOO determination by a new recognition mechanism: amido oxidized nitroso-group by ONOO. Probe L with amine-based recognition receptor is more selective to ONOO than other reactive oxygen species, including H2O2 and ClO. Furthermore, ONOO could be rapidly detected by probe L with a Limit of Detection of 13 nM. More importantly, L could be used to monitor intracellular ONOO in SMMC-7721 cells.

Original languageEnglish
Pages (from-to)96-102
Number of pages7
JournalAnalytica Chimica Acta
Volume1106
DOIs
Publication statusPublished - 15 Apr 2020

Scopus Subject Areas

  • Analytical Chemistry
  • Biochemistry
  • Environmental Chemistry
  • Spectroscopy

User-Defined Keywords

  • Amido oxidized nitroso-group
  • Fluorescent probe
  • Peroxynitrite
  • Reactive oxygen species

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