A dual-functional molecular strategy for in situ suppressing and visualizing of neuraminidase in aqueous solution using iridium(III) complexes

Chun Wu; Ke Jia Wu; Jin Biao Liu; Xiao Ming Zhou; Chung Hang Leung; Edmond Dik Lung MA

doi:10.1039/c9cc02189b

A dual-functional molecular strategy for in situ suppressing and visualizing of neuraminidase in aqueous solution using iridium(III) complexes

Chun Wu
, Ke Jia Wu
, Jin Biao Liu
, Xiao Ming Zhou
, Chung Hang Leung^*
, Edmond Dik Lung MA

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Journal article › peer-review

38 Citations (Scopus)

Abstract

We have designed for the first time a dual-functional luminescent probe and inhibitor of neuraminidase (NA), a key influenza target. The lead iridium(iii) complex exhibited enhanced inhibition against NA compared to the FDA-approved antiviral drug, oseltamivir, and could detect NA even in the presence of an autofluorescent background.

Original language	English
Pages (from-to)	6353-6356
Number of pages	4
Journal	Chemical Communications
Volume	55
Issue number	45
Early online date	1 May 2019
DOIs	https://doi.org/10.1039/c9cc02189b
Publication status	Published - 7 Jun 2019

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SDG 3 Good Health and Well-being

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10.1039/c9cc02189b

Cite this

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title = "A dual-functional molecular strategy for in situ suppressing and visualizing of neuraminidase in aqueous solution using iridium(III) complexes",

abstract = "We have designed for the first time a dual-functional luminescent probe and inhibitor of neuraminidase (NA), a key influenza target. The lead iridium(iii) complex exhibited enhanced inhibition against NA compared to the FDA-approved antiviral drug, oseltamivir, and could detect NA even in the presence of an autofluorescent background.",

author = "Chun Wu and Wu, \{Ke Jia\} and Liu, \{Jin Biao\} and Zhou, \{Xiao Ming\} and Leung, \{Chung Hang\} and MA, \{Edmond Dik Lung\}",

note = "Funding Information: This work is supported by Hong Kong Baptist University (FRG2/17-18/003), the Health and Medical Research Fund (HMRF/14150561), the National Natural Science Foundation of China (21575121, 21775131 and 21762018), the Hong Kong Baptist University Century Club Sponsorship Scheme 2018, the Interdisciplinary Research Matching Scheme (RC-IRMS/16-17/03), Interdisciplinary Research Clusters Matching Scheme (RC-IRCs/ 17-18/03), Collaborative Research Fund (C5026-16G), SKLEBA and HKBU Strategic Development Fund (SKLP\_1718\_P04), the Science and Technology Development Fund, Macao SAR (0072/2018/A2), and the University of Macau (MYRG2016-00151-ICMS-QRCM and MYRG2018-00187-ICMS).",

year = "2019",

month = jun,

day = "7",

doi = "10.1039/c9cc02189b",

language = "English",

volume = "55",

pages = "6353--6356",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "45",

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TY - JOUR

T1 - A dual-functional molecular strategy for in situ suppressing and visualizing of neuraminidase in aqueous solution using iridium(III) complexes

AU - Wu, Chun

AU - Wu, Ke Jia

AU - Liu, Jin Biao

AU - Zhou, Xiao Ming

AU - Leung, Chung Hang

AU - MA, Edmond Dik Lung

N1 - Funding Information: This work is supported by Hong Kong Baptist University (FRG2/17-18/003), the Health and Medical Research Fund (HMRF/14150561), the National Natural Science Foundation of China (21575121, 21775131 and 21762018), the Hong Kong Baptist University Century Club Sponsorship Scheme 2018, the Interdisciplinary Research Matching Scheme (RC-IRMS/16-17/03), Interdisciplinary Research Clusters Matching Scheme (RC-IRCs/ 17-18/03), Collaborative Research Fund (C5026-16G), SKLEBA and HKBU Strategic Development Fund (SKLP_1718_P04), the Science and Technology Development Fund, Macao SAR (0072/2018/A2), and the University of Macau (MYRG2016-00151-ICMS-QRCM and MYRG2018-00187-ICMS).

PY - 2019/6/7

Y1 - 2019/6/7

N2 - We have designed for the first time a dual-functional luminescent probe and inhibitor of neuraminidase (NA), a key influenza target. The lead iridium(iii) complex exhibited enhanced inhibition against NA compared to the FDA-approved antiviral drug, oseltamivir, and could detect NA even in the presence of an autofluorescent background.

AB - We have designed for the first time a dual-functional luminescent probe and inhibitor of neuraminidase (NA), a key influenza target. The lead iridium(iii) complex exhibited enhanced inhibition against NA compared to the FDA-approved antiviral drug, oseltamivir, and could detect NA even in the presence of an autofluorescent background.

UR - https://www.scopus.com/pages/publications/85066440036

U2 - 10.1039/c9cc02189b

DO - 10.1039/c9cc02189b

M3 - Journal article

C2 - 31065657

AN - SCOPUS:85066440036

SN - 1359-7345

VL - 55

SP - 6353

EP - 6356

JO - Chemical Communications

JF - Chemical Communications

IS - 45

ER -

A dual-functional molecular strategy for in situ suppressing and visualizing of neuraminidase in aqueous solution using iridium(III) complexes

Abstract

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