@article{2ac9d415ec634d278ee43e1321653aaa,
title = "A dual-functional luminescent probe for imaging H2S in living zebrafish and discrimination hypoxic cells from normoxic cells",
abstract = "In this work, we present a new reaction-based luminogenic probe with dual functions: a highly selective sensor for both in vitro H2S sensing and in vivo H2S imaging in living zebrafish, and a luminescent agent for imaging hypoxic cells. The mechanism of this platform is based on the reduction of the nitro group in the iridium(III) complex to an amino group, which “turns on” its luminescence. Complex 1 exhibited a linear range of detection for H2S from 0 to 170 μM with a detection limit of 4.35 μM. Complex 1 also shows the ability to detect H2S in HeLa cells and in living zebrafish. Meanwhile, complex 1 is capable of discriminating hypoxic from normoxic cells, and shows potential for monitoring hypoxia in zebrafish model.",
keywords = "Hydrogen sulfide, Iridium(III) complex, Luminescence, Sensor",
author = "Wanhe Wang and Chun Wu and Chao Yang and Guodong Li and Han, {Simon Q B} and Shengnan Li and Lee, {Simon Ming Yuen} and Leung, {Chung Hang} and Ma, {Edmond Dik Lung}",
note = "Funding Information: This work is supported by Hong Kong Baptist University (FRG2/16-17/007), the Health and Medical Research Fund (HMRF/14130522), the Research Grants Council (HKBU/12301115 and HKBU/201913), the National Natural Science Foundation of China (21575121), the Guangdong Province Natural Science Foundation (2015A030313816), the Hong Kong Baptist University Century Club Sponsorship Scheme 2016, the Interdisciplinary Research Matching Scheme (RC-IRMS/14-15/06), Innovation and Technology Fund (ITS/260/16FX), Matching Proof of Concept Fund (MPCF-001-2017/18), the Science and Technology Development Fund, Macao SAR (098/2014/A2 and 007/2014/AMJ), the University of Macau (MYRG2015-00137-ICMS-QRCM, MYRG2016-00151-ICMS-QRCM and MRG044/LCH/2015/ICMS), National Natural Science Foundation of China (21628502). Funding Information: This work is supported by Hong Kong Baptist University ( FRG2/16-17/007 ), the Health and Medical Research Fund ( HMRF/14130522 ), the Research Grants Council ( HKBU/12301115 and HKBU/201913 ), the National Natural Science Foundation of China ( 21575121 ), the Guangdong Province Natural Science Foundation ( 2015A030313816 ), the Hong Kong Baptist University Century Club Sponsorship Scheme 2016 , the Interdisciplinary Research Matching Scheme ( RC-IRMS/14-15/06 ), Innovation and Technology Fund ( ITS/260/16FX ), Matching Proof of Concept Fund ( MPCF-001-2017/18 ), the Science and Technology Development Fund , Macao SAR ( 098/2014/A2 and 007/2014/AMJ ), the University of Macau ( MYRG2015-00137-ICMS-QRCM , MYRG2016-00151-ICMS-QRCM and MRG044/LCH/2015/ICMS ), National Natural Science Foundation of China ( 21628502 ). ",
year = "2018",
month = feb,
doi = "10.1016/j.snb.2017.08.222",
language = "English",
volume = "255",
pages = "1953--1959",
journal = "Sensors and Actuators B: Chemical",
issn = "0925-4005",
publisher = "Elsevier",
}