A cytotoxic nitrido-osmium(vi) complex induces caspase-mediated apoptosis in HepG2 cancer cells

Wan Qiong Huang, Chuan Xian Wang, Tao Liu, Zi Xin Li, Chen Pan, Yun Zhou Chen, Xin Lian, Wai Lun MAN, Wen Xiu Ni*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

The osmium(vi) nitrido complex [OsVI(N)(sap)(py)Cl] is a potential anti-cancer drug with promising in vitro antiproliferative activities toward a panel of cancer cell lines, including cisplatin-resistant cells (IC50 values of 2.8-13.8 μM). This drug targets DNA and changes its conformation via covalent binding and insertion. In vitro studies indicate that the drug induces HepG2 cells G2/M phase arrest, disrupts the mitochondrial membrane potential and causes caspase-mediated apoptosis. Further in vivo studies using HepG2-bearing nude mice reveal that this drug not only shows good antitumor efficacy of inhibiting tumor growth, but also does not show the side effect of weight loss.

Original languageEnglish
Pages (from-to)17173-17182
Number of pages10
JournalDalton Transactions
Volume49
Issue number47
DOIs
Publication statusPublished - 21 Dec 2020

Scopus Subject Areas

  • Inorganic Chemistry

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