@article{080fe02ced4a47f4a204f18b37d202a2,
title = "A cytotoxic nitrido-osmium(vi) complex induces caspase-mediated apoptosis in HepG2 cancer cells",
abstract = "The osmium(vi) nitrido complex [OsVI(N)(sap)(py)Cl] is a potential anti-cancer drug with promising in vitro antiproliferative activities toward a panel of cancer cell lines, including cisplatin-resistant cells (IC50 values of 2.8-13.8 μM). This drug targets DNA and changes its conformation via covalent binding and insertion. In vitro studies indicate that the drug induces HepG2 cells G2/M phase arrest, disrupts the mitochondrial membrane potential and causes caspase-mediated apoptosis. Further in vivo studies using HepG2-bearing nude mice reveal that this drug not only shows good antitumor efficacy of inhibiting tumor growth, but also does not show the side effect of weight loss.",
author = "Huang, {Wan Qiong} and Wang, {Chuan Xian} and Tao Liu and Li, {Zi Xin} and Chen Pan and Chen, {Yun Zhou} and Xin Lian and Man, {Wai Lun} and Ni, {Wen Xiu}",
note = "Funding Information: We thank the Guangdong Major Project of Basic and Applied Basic Research (No. 2019B030302009), the National Natural Science Foundation of China (No. 21401125), funding from the {"}Tezhi Project{"} (No. 201627025) and {"}Yangfan Project{"} (No. 201635031) of Guangdong Province, the Li Ka Shing Foundation Cross-Disciplinary Research Grant (2020LKSFG01F), Hong Kong Baptist University (No. RC-ICRS-18-19-01A) and Shantou University Medical College. Funding Information: We thank the Guangdong Major Project of Basic and Applied Basic Research (No. 2019B030302009), the National Natural Science Foundation of China (No. 21401125), funding from the “Tezhi Project” (No. 201627025) and “Yangfan Project” (No. 201635031) of Guangdong Province, the Li Ka Shing Foundation Cross-Disciplinary Research Grant (2020LKSFG01F), Hong Kong Baptist University (No. RC-ICRS-18-19-01A) and Shantou University Medical College.",
year = "2020",
month = dec,
day = "21",
doi = "10.1039/D0DT02715D",
language = "English",
volume = "49",
pages = "17173--17182",
journal = "Dalton Transactions",
issn = "1477-9226",
publisher = "Royal Society of Chemistry",
number = "47",
}