A critical review on intestinal mucosal barrier protection effects of dietary polysaccharides

Weiqi Yan, Jinhai Luo, Zhiling Yu, Baojun Xu*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)


Studies have shown that dietary polysaccharides, which are widely present in natural foods, have an important impact on the intestinal mucosal barrier. Dietary polysaccharides can maintain the intestinal barrier function through multiple mechanisms. The intestinal barrier is composed of mechanical, chemical, immune, and biological barriers, and dietary polysaccharides, as a bioactive component, can promote and regulate these four barriers. Dietary polysaccharides can enhance the expression of tight junction proteins and mucins such as occludin-1 and zonula occludens-1 (ZO-1) between intestinal epithelial cells, inhibit inflammatory response and oxidative stress, increase the growth of beneficial bacteria, produce beneficial metabolites such as short chain fatty acids (SCFAs), and promote the proliferation and metabolism of immune cells. Given the critical role of the intestinal mucosal system in health and disease, the protective effects of dietary polysaccharides may be potentially valuable for the prevention and treatment of gut-related diseases. Therefore, it is of great significance to further study the mechanism and application prospects of the intestinal mucosal barrier derived from plant, animal, fungal and bacterial sources.

Original languageEnglish
Pages (from-to)481-492
Number of pages12
JournalFood and Function
Issue number2
Early online date18 Dec 2023
Publication statusPublished - Jan 2024

Scopus Subject Areas

  • Food Science


Dive into the research topics of 'A critical review on intestinal mucosal barrier protection effects of dietary polysaccharides'. Together they form a unique fingerprint.

Cite this