A coumarin-based fluorescent probe for recognition of Cu2+ and fast detection of histidine in hard-to-transfect cells by a sensing ensemble approach

Qi Hua You; Albert W M LEE; Wing Hong CHAN; Xiao Ming Zhu; Ken C F LEUNG

doi:10.1039/c4cc00521j

A coumarin-based fluorescent probe for recognition of Cu²⁺ and fast detection of histidine in hard-to-transfect cells by a sensing ensemble approach

Qi Hua You, Albert W M LEE, Wing Hong CHAN^*, Xiao Ming Zhu, Ken C F LEUNG

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

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Abstract

A coumarin-based fluorescent chemosensor CAQA has been synthesized. It can selectively and sensitively recognize Cu²⁺in aqueous acetonitrile solutions. Using the Cu-containing complex CAQA-Cu²⁺as a sensing ensemble, the device demonstrates highly selective recognition of His/biothiols and was applied in fluorescence imaging of histidine in hard-to-transfect living cells.

Original language	English
Pages (from-to)	6207-6210
Number of pages	4
Journal	Chemical Communications
Volume	50
Issue number	47
DOIs	https://doi.org/10.1039/c4cc00521j
Publication status	Published - 16 May 2014

Scopus Subject Areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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AU - Zhu, Xiao Ming

AU - LEUNG, Ken C F

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AB - A coumarin-based fluorescent chemosensor CAQA has been synthesized. It can selectively and sensitively recognize Cu2+in aqueous acetonitrile solutions. Using the Cu-containing complex CAQA-Cu2+as a sensing ensemble, the device demonstrates highly selective recognition of His/biothiols and was applied in fluorescence imaging of histidine in hard-to-transfect living cells.

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A coumarin-based fluorescent probe for recognition of Cu²⁺ and fast detection of histidine in hard-to-transfect cells by a sensing ensemble approach

Abstract

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