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A convenient method for modifying poly(dimethylsiloxane) with poly(ethylene glycol) in microfludics

  • Jianhua Zhou
  • , Hui Yan
  • , Kanning Ren
  • , Wen Dai
  • , Hongkai Wu

Research output: Chapter in book/report/conference proceedingConference proceedingpeer-review

Abstract

This paper describes a convenient method for the covalent modification of PDMS with PEG chains to suppress nonspecific protein adsorption. PEG additives terminated with a vinyl groups react with the silane groups on the PDMS during thermally curing, covalently linking PEG groups to the PDMS network. The PEG modified PDMS surfaces are characterized with FTIR, XPS and contact angle measurement. We also examined the modified PDMS for on-chip capillary electrophoresis and its capability of resisting nonspecific protein adsorption using BSA as model. Based on our study, a molecular mechanism is given to explain the surface properties of the modified PDMS surfaces.

Original languageEnglish
Title of host publicationProceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences
EditorsTae Yoon Lee, Kyudong Han, Dimitris E Nikitopoulos, Steve Allan Soper, Mark A Batzer, Michael C Murphy
PublisherChemical and Biological Microsystems Society
Pages241-247
Number of pages7
ISBN (Print)9780979806421
Publication statusPublished - 1 Nov 2009
Event13th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2009 - Jeju, Korea, Republic of
Duration: 1 Nov 20095 Nov 2009

Publication series

NameProceedings of the International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS

Conference

Conference13th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2009
Country/TerritoryKorea, Republic of
CityJeju
Period1/11/095/11/09

User-Defined Keywords

  • Electrophoresis
  • Microfluidics
  • Poly(dimethylsiloxane)
  • Poly(ethylene glycol)
  • Surface modification

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