@article{b65acd3aff2448c788d27530451bdb7c,
title = "A Comprehensive Human Gastric Cancer Organoid Biobank Captures Tumor Subtype Heterogeneity and Enables Therapeutic Screening",
abstract = "Leung and colleagues established a biobank of patient-derived gastric cancer organoids that encompasses a diverse array of subtypes and maintained long-term similarity to the original tumors. They used the organoids to perform large-scale drug screening that identified potential target drugs and could guide patient drug selection.",
keywords = "ARHGAP fusions, biobank, drug screening, EBV genome, gastric cancer, heterogeneity, organoid culture, RHOA mutations, transcriptome sequencing, whole-exome sequencing",
author = "Yan, {Helen H.N.} and Siu, {Hoi Cheong} and Simon Law and Ho, {Siu Lun} and Yue, {Sarah S.K.} and Tsui, {Wai Yin} and Dessy Chan and Chan, {April S.} and Stephanie Ma and Lam, {Ka On} and Sina Bartfeld and Man, {Alice H.Y.} and Lee, {Bernard C.H.} and Chan, {Annie S.Y.} and Wong, {Jason W.H.} and Cheng, {Priscilla S.W.} and Chan, {Anthony K.W.} and Jiangwen Zhang and Jue SHI and Xiaodan Fan and Kwong, {Dora L.W.} and Mak, {Tak W.} and Yuen, {Siu Tsan} and Hans Clevers and Leung, {Suet Yi}",
note = "Funding Information: We thank clinicians in the Hong Kong West Cluster, Hospital Authority for clinical care and sample coordination, and H. Wong, H.S. Hui, and H.C. Leung for technical support. We thank the Centre for Genomics Sciences, The University of Hong Kong for performing WES and RNA-seq experiments, and the Core Facility of the LKS Faculty of Medicine HKU for providing imaging and flow cytometry support. We also thank H.E. Francies and M.J. Garnett of Wellcome Trust Sanger Institute for advice on drug screening. This work was substantially supported by a theme-based research grant from the Research Grants Council of the Hong Kong Special Administrative Region, China (Project No. T12-710/16-R ), and partly by the Y.W. Kan Endowed Professorship established through a donation from the Croucher Foundation. Equipment support for drug screening was provided by the Jockey Club Centre for Clinical Innovation and Discovery. ",
year = "2018",
month = dec,
day = "6",
doi = "10.1016/j.stem.2018.09.016",
language = "English",
volume = "23",
pages = "882--897, e1--e11",
journal = "Cell Stem Cell",
issn = "1934-5909",
publisher = "Cell Press",
number = "6",
}
