A Comprehensive Human Gastric Cancer Organoid Biobank Captures Tumor Subtype Heterogeneity and Enables Therapeutic Screening

Helen H.N. Yan*, Hoi Cheong Siu, Simon Law, Siu Lun Ho, Sarah S.K. Yue, Wai Yin Tsui, Dessy Chan, April S. Chan, Stephanie Ma, Ka On Lam, Sina Bartfeld, Alice H.Y. Man, Bernard C.H. Lee, Annie S.Y. Chan, Jason W.H. Wong, Priscilla S.W. Cheng, Anthony K.W. Chan, Jiangwen Zhang, Jue SHI, Xiaodan FanDora L.W. Kwong, Tak W. Mak, Siu Tsan Yuen, Hans Clevers, Suet Yi Leung

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

124 Citations (Scopus)

Abstract

Leung and colleagues established a biobank of patient-derived gastric cancer organoids that encompasses a diverse array of subtypes and maintained long-term similarity to the original tumors. They used the organoids to perform large-scale drug screening that identified potential target drugs and could guide patient drug selection.

Original languageEnglish
Pages (from-to)882-897.e11
JournalCell Stem Cell
Volume23
Issue number6
DOIs
Publication statusPublished - 6 Dec 2018

Scopus Subject Areas

  • Molecular Medicine
  • Genetics
  • Cell Biology

User-Defined Keywords

  • ARHGAP fusions
  • biobank
  • drug screening
  • EBV genome
  • gastric cancer
  • heterogeneity
  • organoid culture
  • RHOA mutations
  • transcriptome sequencing
  • whole-exome sequencing

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