A comparative study of recording procedures for motor evoked potential signals

Gracee Agrawal; Shrivats Iyer; Angelo H. All

doi:10.1109/IEMBS.2009.5333953

A comparative study of recording procedures for motor evoked potential signals

Gracee Agrawal^*
, Shrivats Iyer
, Angelo H. All

^*Corresponding author for this work

Department of Chemistry

Research output: Chapter in book/report/conference proceeding › Conference proceeding › peer-review

27 Citations (Scopus)

Abstract

Motor evoked potential (MEP) signals serve as an objective measure of the functional integrity of motor pathways in the spinal cord. Hence, they provide a reliable assessment of the extent of spinal cord injury (SCI). There are two methods currently being used for serial MEP recordings in rats: a low-frequency and a high-frequency method. In this paper, we compared the two methods and determined the better method for MEP recordings. We also compared the effect of two anesthetic agents - inhalational isoflurane and intraperitoneal ketamine - on the MEP signals. We found that under ketamine anesthesia, low-frequency stimulation led to more consistent results, while high-frequency stimulation required greater stimulation intensity and was prone to unwanted side-effects including excessive head twitches. We further found that isoflurane anesthesia severely depressed the MEP response for both low-frequency and high-frequency stimulation which rendered the resulting signal unusable.

Original language	English
Title of host publication	Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2009
Place of Publication	Minneapolis
Publisher	IEEE
Pages	2086-2089
Number of pages	4
ISBN (Print)	9781424432967
DOIs	https://doi.org/10.1109/IEMBS.2009.5333953
Publication status	Published - 3 Sept 2009
Event	31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine - Hilton Minneapolis, Minneapolis, United States Duration: 2 Sept 2009 → 6 Sept 2009 https://ieeexplore.ieee.org/xpl/conhome/5307844/proceeding (Conference proceeding)

Publication series

Name	Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC
ISSN (Print)	1094-687X
ISSN (Electronic)	1558-4615

Conference

Conference	31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Abbreviated title	EMBC 2009
Country/Territory	United States
City	Minneapolis
Period	2/09/09 → 6/09/09
Internet address	https://ieeexplore.ieee.org/xpl/conhome/5307844/proceeding (Conference proceeding)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Access to Document

10.1109/IEMBS.2009.5333953

Cite this

Agrawal, G., Iyer, S., & All, A. H. (2009). A comparative study of recording procedures for motor evoked potential signals. In Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2009 (pp. 2086-2089). Article 5333953 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC). IEEE. https://doi.org/10.1109/IEMBS.2009.5333953

Agrawal, Gracee ; Iyer, Shrivats ; All, Angelo H. / A comparative study of recording procedures for motor evoked potential signals. Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2009. Minneapolis : IEEE, 2009. pp. 2086-2089 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC).

@inproceedings{bde6b6cdf6a04d289b9f9afefe73a94b,

title = "A comparative study of recording procedures for motor evoked potential signals",

abstract = "Motor evoked potential (MEP) signals serve as an objective measure of the functional integrity of motor pathways in the spinal cord. Hence, they provide a reliable assessment of the extent of spinal cord injury (SCI). There are two methods currently being used for serial MEP recordings in rats: a low-frequency and a high-frequency method. In this paper, we compared the two methods and determined the better method for MEP recordings. We also compared the effect of two anesthetic agents - inhalational isoflurane and intraperitoneal ketamine - on the MEP signals. We found that under ketamine anesthesia, low-frequency stimulation led to more consistent results, while high-frequency stimulation required greater stimulation intensity and was prone to unwanted side-effects including excessive head twitches. We further found that isoflurane anesthesia severely depressed the MEP response for both low-frequency and high-frequency stimulation which rendered the resulting signal unusable.",

author = "Gracee Agrawal and Shrivats Iyer and All, \{Angelo H.\}",

note = "This work was supported by the Maryland Stem Cell Research Fund (2007-MSCRFII-0159-00) Publisher Copyright: {\textcopyright}2009 IEEE; 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society : Engineering the Future of Biomedicine, EMBC 2009 ; Conference date: 02-09-2009 Through 06-09-2009",

year = "2009",

month = sep,

day = "3",

doi = "10.1109/IEMBS.2009.5333953",

language = "English",

isbn = "9781424432967",

series = "Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC",

publisher = "IEEE",

pages = "2086--2089",

booktitle = "Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2009",

address = "United States",

url = "https://ieeexplore.ieee.org/xpl/conhome/5307844/proceeding",

}

Agrawal, G, Iyer, S & All, AH 2009, A comparative study of recording procedures for motor evoked potential signals. in Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2009., 5333953, Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC, IEEE, Minneapolis, pp. 2086-2089, 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Minneapolis, Minnesota, United States, 2/09/09. https://doi.org/10.1109/IEMBS.2009.5333953

A comparative study of recording procedures for motor evoked potential signals. / Agrawal, Gracee; Iyer, Shrivats; All, Angelo H.
Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2009. Minneapolis: IEEE, 2009. p. 2086-2089 5333953 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC).

Research output: Chapter in book/report/conference proceeding › Conference proceeding › peer-review

TY - GEN

T1 - A comparative study of recording procedures for motor evoked potential signals

AU - Agrawal, Gracee

AU - Iyer, Shrivats

AU - All, Angelo H.

PY - 2009/9/3

Y1 - 2009/9/3

N2 - Motor evoked potential (MEP) signals serve as an objective measure of the functional integrity of motor pathways in the spinal cord. Hence, they provide a reliable assessment of the extent of spinal cord injury (SCI). There are two methods currently being used for serial MEP recordings in rats: a low-frequency and a high-frequency method. In this paper, we compared the two methods and determined the better method for MEP recordings. We also compared the effect of two anesthetic agents - inhalational isoflurane and intraperitoneal ketamine - on the MEP signals. We found that under ketamine anesthesia, low-frequency stimulation led to more consistent results, while high-frequency stimulation required greater stimulation intensity and was prone to unwanted side-effects including excessive head twitches. We further found that isoflurane anesthesia severely depressed the MEP response for both low-frequency and high-frequency stimulation which rendered the resulting signal unusable.

AB - Motor evoked potential (MEP) signals serve as an objective measure of the functional integrity of motor pathways in the spinal cord. Hence, they provide a reliable assessment of the extent of spinal cord injury (SCI). There are two methods currently being used for serial MEP recordings in rats: a low-frequency and a high-frequency method. In this paper, we compared the two methods and determined the better method for MEP recordings. We also compared the effect of two anesthetic agents - inhalational isoflurane and intraperitoneal ketamine - on the MEP signals. We found that under ketamine anesthesia, low-frequency stimulation led to more consistent results, while high-frequency stimulation required greater stimulation intensity and was prone to unwanted side-effects including excessive head twitches. We further found that isoflurane anesthesia severely depressed the MEP response for both low-frequency and high-frequency stimulation which rendered the resulting signal unusable.

UR - https://www.scopus.com/pages/publications/77950977350

UR - https://ieeexplore.ieee.org/document/5333953

U2 - 10.1109/IEMBS.2009.5333953

DO - 10.1109/IEMBS.2009.5333953

M3 - Conference proceeding

C2 - 19964577

AN - SCOPUS:77950977350

SN - 9781424432967

T3 - Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC

SP - 2086

EP - 2089

BT - Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2009

PB - IEEE

CY - Minneapolis

T2 - 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society

Y2 - 2 September 2009 through 6 September 2009

ER -

Agrawal G, Iyer S, All AH. A comparative study of recording procedures for motor evoked potential signals. In Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2009. Minneapolis: IEEE. 2009. p. 2086-2089. 5333953. (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC). doi: 10.1109/IEMBS.2009.5333953

A comparative study of recording procedures for motor evoked potential signals

Abstract

Publication series

Conference

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this