A comparable, chemical and pharmacological analysis of the traditional Chinese medicinal herbs Oldenlandia diffusa and O. corymbosa and a new valuation of their biological potential

Zhitao LIANG; Mingfang He; David W F FONG; Zhi Hong JIANG; Zhongzhen ZHAO

doi:10.1016/j.phymed.2008.01.003

A comparable, chemical and pharmacological analysis of the traditional Chinese medicinal herbs Oldenlandia diffusa and O. corymbosa and a new valuation of their biological potential

Zhitao LIANG, Mingfang He, David W F FONG, Zhi Hong JIANG, Zhongzhen ZHAO^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › peer-review

34 Citations (Scopus)

Abstract

The herb of Oldenlandia diffusa (Willd.) Roxb. (Family Rubiaceae) is well-known in Chinese folk medicine for the treatment of hepatitis and malignant tumors of the liver, lung and stomach. However, another herb of O. corymbosa (L.) Lam is also used interchangeably in South China for treating the same conditions. To compare the efficacy of the two herbs, the antiproliferative effect of their extracts and the antiangiogenic activity of their main constituents were appraised. The Sulforhodamine B (SRB) assay in human hepatoma HepG2 cells and human colon carcinoma CaCo2 cells and the zebrafish angiogenic model were used for this purpose. The results showed almost no antiproliferative effect of the methanol extracts from O. diffusa and O. corymbosa, while the chloroform extracts exhibited slightly antiproliferative effects. The main components had almost no effect on zebrafish angiogenic vessel formation at the concentrations tested. The results suggest that the mechanism of antitumor activity of O. diffusa may not be attributed to the antiproliferative and antiangiogenic effects.

Original language	English
Pages (from-to)	259-267
Number of pages	9
Journal	Phytomedicine
Volume	15
Issue number	4
DOIs	https://doi.org/10.1016/j.phymed.2008.01.003
Publication status	Published - 25 Apr 2008

Scopus Subject Areas

Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine

User-Defined Keywords

Antiproliferative
Antitumor
High-performance liquid chromatography (HPLC)
Oldenlandia corymbosa
Oldenlandia diffusa

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.phymed.2008.01.003

Cite this

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title = "A comparable, chemical and pharmacological analysis of the traditional Chinese medicinal herbs Oldenlandia diffusa and O. corymbosa and a new valuation of their biological potential",

abstract = "The herb of Oldenlandia diffusa (Willd.) Roxb. (Family Rubiaceae) is well-known in Chinese folk medicine for the treatment of hepatitis and malignant tumors of the liver, lung and stomach. However, another herb of O. corymbosa (L.) Lam is also used interchangeably in South China for treating the same conditions. To compare the efficacy of the two herbs, the antiproliferative effect of their extracts and the antiangiogenic activity of their main constituents were appraised. The Sulforhodamine B (SRB) assay in human hepatoma HepG2 cells and human colon carcinoma CaCo2 cells and the zebrafish angiogenic model were used for this purpose. The results showed almost no antiproliferative effect of the methanol extracts from O. diffusa and O. corymbosa, while the chloroform extracts exhibited slightly antiproliferative effects. The main components had almost no effect on zebrafish angiogenic vessel formation at the concentrations tested. The results suggest that the mechanism of antitumor activity of O. diffusa may not be attributed to the antiproliferative and antiangiogenic effects.",

keywords = "Antiproliferative, Antitumor, High-performance liquid chromatography (HPLC), Oldenlandia corymbosa, Oldenlandia diffusa",

author = "Zhitao LIANG and Mingfang He and FONG, {David W F} and JIANG, {Zhi Hong} and Zhongzhen ZHAO",

note = "Funding Information: The authors would like to acknowledge their thanks to Ms. Shen Xiaoling (Department of Biology and Chemistry, City University of Hong Kong) for comments. The project was supported by the Faculty Research Grant of Hong Kong Baptist University (FRG/04-05/II-55).",

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doi = "10.1016/j.phymed.2008.01.003",

language = "English",

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A comparable, chemical and pharmacological analysis of the traditional Chinese medicinal herbs Oldenlandia diffusa and O. corymbosa and a new valuation of their biological potential. / LIANG, Zhitao; He, Mingfang; FONG, David W F et al.
In: Phytomedicine, Vol. 15, No. 4, 25.04.2008, p. 259-267.

Research output: Contribution to journal › Journal article › peer-review

TY - JOUR

T1 - A comparable, chemical and pharmacological analysis of the traditional Chinese medicinal herbs Oldenlandia diffusa and O. corymbosa and a new valuation of their biological potential

AU - LIANG, Zhitao

AU - He, Mingfang

AU - FONG, David W F

AU - JIANG, Zhi Hong

AU - ZHAO, Zhongzhen

N1 - Funding Information: The authors would like to acknowledge their thanks to Ms. Shen Xiaoling (Department of Biology and Chemistry, City University of Hong Kong) for comments. The project was supported by the Faculty Research Grant of Hong Kong Baptist University (FRG/04-05/II-55).

PY - 2008/4/25

Y1 - 2008/4/25

N2 - The herb of Oldenlandia diffusa (Willd.) Roxb. (Family Rubiaceae) is well-known in Chinese folk medicine for the treatment of hepatitis and malignant tumors of the liver, lung and stomach. However, another herb of O. corymbosa (L.) Lam is also used interchangeably in South China for treating the same conditions. To compare the efficacy of the two herbs, the antiproliferative effect of their extracts and the antiangiogenic activity of their main constituents were appraised. The Sulforhodamine B (SRB) assay in human hepatoma HepG2 cells and human colon carcinoma CaCo2 cells and the zebrafish angiogenic model were used for this purpose. The results showed almost no antiproliferative effect of the methanol extracts from O. diffusa and O. corymbosa, while the chloroform extracts exhibited slightly antiproliferative effects. The main components had almost no effect on zebrafish angiogenic vessel formation at the concentrations tested. The results suggest that the mechanism of antitumor activity of O. diffusa may not be attributed to the antiproliferative and antiangiogenic effects.

AB - The herb of Oldenlandia diffusa (Willd.) Roxb. (Family Rubiaceae) is well-known in Chinese folk medicine for the treatment of hepatitis and malignant tumors of the liver, lung and stomach. However, another herb of O. corymbosa (L.) Lam is also used interchangeably in South China for treating the same conditions. To compare the efficacy of the two herbs, the antiproliferative effect of their extracts and the antiangiogenic activity of their main constituents were appraised. The Sulforhodamine B (SRB) assay in human hepatoma HepG2 cells and human colon carcinoma CaCo2 cells and the zebrafish angiogenic model were used for this purpose. The results showed almost no antiproliferative effect of the methanol extracts from O. diffusa and O. corymbosa, while the chloroform extracts exhibited slightly antiproliferative effects. The main components had almost no effect on zebrafish angiogenic vessel formation at the concentrations tested. The results suggest that the mechanism of antitumor activity of O. diffusa may not be attributed to the antiproliferative and antiangiogenic effects.

KW - Antiproliferative

KW - Antitumor

KW - High-performance liquid chromatography (HPLC)

KW - Oldenlandia corymbosa

KW - Oldenlandia diffusa

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AN - SCOPUS:41149153222

SN - 0944-7113

VL - 15

SP - 259

EP - 267

JO - Phytomedicine

JF - Phytomedicine

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ER -

A comparable, chemical and pharmacological analysis of the traditional Chinese medicinal herbs Oldenlandia diffusa and O. corymbosa and a new valuation of their biological potential

Abstract

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