A colorimetric and ratiometric fluorescent pH probe based on ring opening/closing approach and its applications in monitoring cellular pH change

  • Qi-Hua You
  • , Yee Man Lee
  • , Wing Hong Chan*
  • , Nai Ki Mak
  • , Albert W. M. Lee
  • , Sam C. K. Hau
  • , Thomas C. W. Mak
  • *Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

9 Citations (Scopus)
54 Downloads (Pure)

Abstract

A colorimetric and ratiometric fluorescent pH probe with a pKa value of 6.0 based on a ring opening/closing approach of N,O-disubstituted hemiaminal ether has been developed. The probe exhibits fast response toward pH change with high selectivity and low cytotoxicity and was applied in HK-1 cells to visualize pH change.

Original languageEnglish
Pages (from-to)4099-4102
Number of pages4
JournalRSC Advances
Volume5
Issue number6
Early online date8 Dec 2014
DOIs
Publication statusPublished - 2015

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