A colorimetric and ratiometric fluorescent pH probe based on ring opening/closing approach and its applications in monitoring cellular pH change

Qi Hua You; Yee Man Lee; Wing Hong CHAN; Nai Ki MAK; Albert W M LEE; Sam C K HAU; Thomas C.W. Mak

doi:10.1039/c4ra13445a

A colorimetric and ratiometric fluorescent pH probe based on ring opening/closing approach and its applications in monitoring cellular pH change

Qi Hua You, Yee Man Lee, Wing Hong CHAN^*, Nai Ki MAK, Albert W M LEE, Sam C K HAU, Thomas C.W. Mak

^*Corresponding author for this work

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Abstract

A colorimetric and ratiometric fluorescent pH probe with a pK_a value of 6.0 based on a ring opening/closing approach of N,O-disubstituted hemiaminal ether has been developed. The probe exhibits fast response toward pH change with high selectivity and low cytotoxicity and was applied in HK-1 cells to visualize pH change.

Original language	English
Pages (from-to)	4099-4102
Number of pages	4
Journal	RSC Advances
Volume	5
Issue number	6
DOIs	https://doi.org/10.1039/c4ra13445a
Publication status	Published - 2015

Scopus Subject Areas

Chemistry(all)
Chemical Engineering(all)

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abstract = "A colorimetric and ratiometric fluorescent pH probe with a pKa value of 6.0 based on a ring opening/closing approach of N,O-disubstituted hemiaminal ether has been developed. The probe exhibits fast response toward pH change with high selectivity and low cytotoxicity and was applied in HK-1 cells to visualize pH change.",

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AU - You, Qi Hua

AU - Lee, Yee Man

AU - CHAN, Wing Hong

AU - MAK, Nai Ki

AU - LEE, Albert W M

AU - HAU, Sam C K

AU - Mak, Thomas C.W.

PY - 2015

Y1 - 2015

N2 - A colorimetric and ratiometric fluorescent pH probe with a pKa value of 6.0 based on a ring opening/closing approach of N,O-disubstituted hemiaminal ether has been developed. The probe exhibits fast response toward pH change with high selectivity and low cytotoxicity and was applied in HK-1 cells to visualize pH change.

AB - A colorimetric and ratiometric fluorescent pH probe with a pKa value of 6.0 based on a ring opening/closing approach of N,O-disubstituted hemiaminal ether has been developed. The probe exhibits fast response toward pH change with high selectivity and low cytotoxicity and was applied in HK-1 cells to visualize pH change.

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JO - RSC Advances

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A colorimetric and ratiometric fluorescent pH probe based on ring opening/closing approach and its applications in monitoring cellular pH change

Abstract

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