A colorimetric and ratiometric fluorescent pH probe based on ring opening/closing approach and its applications in monitoring cellular pH change

Qi-Hua You; Yee Man Lee; Wing Hong Chan; Nai Ki Mak; Albert W. M. Lee; Sam C. K. Hau; Thomas C. W. Mak

doi:10.1039/c4ra13445a

A colorimetric and ratiometric fluorescent pH probe based on ring opening/closing approach and its applications in monitoring cellular pH change

Qi-Hua You, Yee Man Lee, Wing Hong Chan^*, Nai Ki Mak, Albert W. M. Lee, Sam C. K. Hau, Thomas C. W. Mak

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › peer-review

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Abstract

A colorimetric and ratiometric fluorescent pH probe with a pK_a value of 6.0 based on a ring opening/closing approach of N,O-disubstituted hemiaminal ether has been developed. The probe exhibits fast response toward pH change with high selectivity and low cytotoxicity and was applied in HK-1 cells to visualize pH change.

Original language	English
Pages (from-to)	4099-4102
Number of pages	4
Journal	RSC Advances
Volume	5
Issue number	6
Early online date	8 Dec 2014
DOIs	https://doi.org/10.1039/c4ra13445a
Publication status	Published - 2015

Scopus Subject Areas

Chemistry(all)
Chemical Engineering(all)

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title = "A colorimetric and ratiometric fluorescent pH probe based on ring opening/closing approach and its applications in monitoring cellular pH change",

abstract = "A colorimetric and ratiometric fluorescent pH probe with a pKa value of 6.0 based on a ring opening/closing approach of N,O-disubstituted hemiaminal ether has been developed. The probe exhibits fast response toward pH change with high selectivity and low cytotoxicity and was applied in HK-1 cells to visualize pH change.",

author = "Qi-Hua You and Lee, {Yee Man} and Chan, {Wing Hong} and Mak, {Nai Ki} and Lee, {Albert W. M.} and Hau, {Sam C. K.} and Mak, {Thomas C. W.}",

note = "The work was supported by Partner State Key Laboratory of Environmental and Biological Analysis and Strategic Development Fund of HKBU. ",

year = "2015",

doi = "10.1039/c4ra13445a",

language = "English",

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journal = "RSC Advances",

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T1 - A colorimetric and ratiometric fluorescent pH probe based on ring opening/closing approach and its applications in monitoring cellular pH change

AU - You, Qi-Hua

AU - Lee, Yee Man

AU - Chan, Wing Hong

AU - Mak, Nai Ki

AU - Lee, Albert W. M.

AU - Hau, Sam C. K.

AU - Mak, Thomas C. W.

N1 - The work was supported by Partner State Key Laboratory of Environmental and Biological Analysis and Strategic Development Fund of HKBU.

PY - 2015

Y1 - 2015

N2 - A colorimetric and ratiometric fluorescent pH probe with a pKa value of 6.0 based on a ring opening/closing approach of N,O-disubstituted hemiaminal ether has been developed. The probe exhibits fast response toward pH change with high selectivity and low cytotoxicity and was applied in HK-1 cells to visualize pH change.

AB - A colorimetric and ratiometric fluorescent pH probe with a pKa value of 6.0 based on a ring opening/closing approach of N,O-disubstituted hemiaminal ether has been developed. The probe exhibits fast response toward pH change with high selectivity and low cytotoxicity and was applied in HK-1 cells to visualize pH change.

UR - http://www.scopus.com/inward/record.url?scp=84919608415&partnerID=8YFLogxK

U2 - 10.1039/c4ra13445a

DO - 10.1039/c4ra13445a

M3 - Journal article

AN - SCOPUS:84919608415

SN - 2046-2069

VL - 5

SP - 4099

EP - 4102

JO - RSC Advances

JF - RSC Advances

IS - 6

ER -

A colorimetric and ratiometric fluorescent pH probe based on ring opening/closing approach and its applications in monitoring cellular pH change

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