A colorimetric and ratiometric fluorescent pH probe based on ring opening/closing approach and its applications in monitoring cellular pH change

Qi Hua You, Yee Man Lee, Wing Hong CHAN*, Nai Ki MAK, Albert W M LEE, Sam C K HAU, Thomas C.W. Mak

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

A colorimetric and ratiometric fluorescent pH probe with a pKa value of 6.0 based on a ring opening/closing approach of N,O-disubstituted hemiaminal ether has been developed. The probe exhibits fast response toward pH change with high selectivity and low cytotoxicity and was applied in HK-1 cells to visualize pH change.

Original languageEnglish
Pages (from-to)4099-4102
Number of pages4
JournalRSC Advances
Volume5
Issue number6
DOIs
Publication statusPublished - 2015

Scopus Subject Areas

  • Chemistry(all)
  • Chemical Engineering(all)

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