A Citrate Synthase Splice Variant Rewires the TCA Cycle to Promote Colorectal Cancer Progression

Keyphrases

• Tricarboxylic Acid Cycle (TCA cycle) 100%
• Colorectal Cancer Progression 100%
• Splice Variant 100%
• Citrate Synthase 100%
• Colorectal Cancer 15%
• Heterocomplex 15%
• Small Molecules 10%
• Colorectal Carcinogenesis 10%
• Dysregulation 5%
• Mitochondria 5%
• Tumor Growth 5%
• Survival Outcomes 5%
• Metabolic Alterations 5%
• Promising Treatment 5%
• Antiproliferative Activity 5%
• Enzymatic Function 5%
• Colorectal Cancer Cells 5%
• Cycle Flux 5%
• Strong Correlation 5%
• Metabolic Reprogramming 5%
• Tumor Metastasis 5%
• Cancer Tumor 5%
• Splice Isoforms 5%
• Gene Signature 5%
• Treatment Strategy 5%
• Epigenomics 5%
• Metabolic Flux 5%
• Homodimer 5%
• In Silico Screening 5%
• Functional Experiments 5%
• Cancer Hallmarks 5%
• Colorectal Cancer Cell Lines 5%
• Patients with Colorectal Cancer 5%
• Cancer Recurrence 5%
• Clinical Analysis 5%
• Organoid Models 5%
• Tricarboxylic Acid 5%
• Aggressive Phenotype 5%
• Cell Line Models 5%
• Central Metabolic Pathways 5%
• Mitochondrium 5%
• Oncometabolite 5%
• 2-Hydroxyglutarate (2-HG) 5%
• Oncogenic Gene 5%
• Epigenetic Reprogramming 5%

Medicine and Dentistry

• Colorectal Carcinoma 100%
• Citric Acid Cycle 100%
• Cancer Growth 100%
• Citrate Synthase 100%
• Carcinogenesis 10%
• In Vitro 5%
• Tumor Progression 5%
• Malignant Neoplasm 5%
• Cancer Cell 5%
• Mitochondrion 5%
• Upregulation 5%
• Enzyme Activity 5%
• Metastatic Carcinoma 5%
• Antiproliferative Activity 5%
• Homodimer 5%
• In Silico 5%
• Organoid 5%
• Oncogene 5%
• Colorectal Cancer Cell Line 5%
• Cancer Recurrence 5%
• Tumor 5%
• 2 Hydroxyglutaric Acid 5%
• Tricarboxylic Acid 5%

Biochemistry, Genetics and Molecular Biology

• Citric Acid Cycle 100%
• Citrate Synthase 100%
• Isoform 15%
• Small Molecule 10%
• Cancer Cell 10%
• Carcinogenesis 10%
• Reprogramming 10%
• Mitochondrion 5%
• Metabolic Pathway 5%
• Upregulation 5%
• Epigenetics 5%
• Antiproliferative Activity 5%
• Enzyme Activity 5%
• Tumor Progression 5%
• Oncogene 5%
• Metabolic Flux 5%
• Gene Signature 5%