A BODIPY-based fluorescent sensor for the detection of Pt2+ and Pt drugs

Fung Kit Tang; Jiaqian Zhu; Fred Ka Wai Kong; Maggie Ng; Qingyuan Bian; Vivian Wing Wah Yam; Anfernee K W Tse; Yu Chung Tse; Ken C F Leung

doi:10.1039/d0cc00027b

A BODIPY-based fluorescent sensor for the detection of Pt²⁺ and Pt drugs

Fung Kit Tang
, Jiaqian Zhu
, Fred Ka Wai Kong
, Maggie Ng
, Qingyuan Bian
, Vivian Wing Wah Yam^*
, Anfernee K W Tse^*
, Yu Chung Tse^*
, Ken C F Leung^*

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Journal article › peer-review

49 Citations (Scopus)

Abstract

A BODIPY-based fluorescent sensor PS with an NO₄S₂ podand ligand was studied for the selective detection of Pt²⁺ over 21 cations as well as selected platinum drugs in aqueous medium. The platinum sensor PS shows 28-fold, 22-fold and 14-fold fluorescence turn-on enhancements to Pt²⁺, cisplatin and nedaplatin, and was thereby employed to detect platinum drugs in A-549 human lung cancer cells.

Original language	English
Pages (from-to)	2695-2698
Number of pages	4
Journal	Chemical Communications
Volume	56
Issue number	18
DOIs	https://doi.org/10.1039/d0cc00027b
Publication status	Published - 4 Mar 2020

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SDG 3 Good Health and Well-being

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10.1039/d0cc00027b

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@article{5e2ce39dc1364d53b1fe2d1703fae771,

title = "A BODIPY-based fluorescent sensor for the detection of Pt2+ and Pt drugs",

abstract = "A BODIPY-based fluorescent sensor PS with an NO4S2 podand ligand was studied for the selective detection of Pt2+ over 21 cations as well as selected platinum drugs in aqueous medium. The platinum sensor PS shows 28-fold, 22-fold and 14-fold fluorescence turn-on enhancements to Pt2+, cisplatin and nedaplatin, and was thereby employed to detect platinum drugs in A-549 human lung cancer cells.",

author = "Tang, \{Fung Kit\} and Jiaqian Zhu and Kong, \{Fred Ka Wai\} and Maggie Ng and Qingyuan Bian and Yam, \{Vivian Wing Wah\} and Tse, \{Anfernee K W\} and Tse, \{Yu Chung\} and Leung, \{Ken C F\}",

note = "Funding Information: The authors acknowledge the mass spectrometry assistance by Dr Judy T. S. Lum in the Department of Chemistry, Dr Tao Wang and Mr David T. W. Chik from the State Key Laboratory of Environmental and Biological Analysis, HKBU. F.-K. T. acknowledges Ms Regina Huang in the Department of Chemistry, HKBU, for the discussion and design of experiments. K. C.-F. L. acknowledges the financial support from the State Key Laboratory of Environmental and Biological Analysis and the President{\textquoteright}s Award for Outstanding Performance in Research Supervision of HKBU. The computations were performed using the research computing facilities offered by the HKU Information Technology Services (ITS).",

year = "2020",

month = mar,

day = "4",

doi = "10.1039/d0cc00027b",

language = "English",

volume = "56",

pages = "2695--2698",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "18",

}

TY - JOUR

T1 - A BODIPY-based fluorescent sensor for the detection of Pt2+ and Pt drugs

AU - Tang, Fung Kit

AU - Zhu, Jiaqian

AU - Kong, Fred Ka Wai

AU - Ng, Maggie

AU - Bian, Qingyuan

AU - Yam, Vivian Wing Wah

AU - Tse, Anfernee K W

AU - Tse, Yu Chung

AU - Leung, Ken C F

N1 - Funding Information: The authors acknowledge the mass spectrometry assistance by Dr Judy T. S. Lum in the Department of Chemistry, Dr Tao Wang and Mr David T. W. Chik from the State Key Laboratory of Environmental and Biological Analysis, HKBU. F.-K. T. acknowledges Ms Regina Huang in the Department of Chemistry, HKBU, for the discussion and design of experiments. K. C.-F. L. acknowledges the financial support from the State Key Laboratory of Environmental and Biological Analysis and the President’s Award for Outstanding Performance in Research Supervision of HKBU. The computations were performed using the research computing facilities offered by the HKU Information Technology Services (ITS).

PY - 2020/3/4

Y1 - 2020/3/4

N2 - A BODIPY-based fluorescent sensor PS with an NO4S2 podand ligand was studied for the selective detection of Pt2+ over 21 cations as well as selected platinum drugs in aqueous medium. The platinum sensor PS shows 28-fold, 22-fold and 14-fold fluorescence turn-on enhancements to Pt2+, cisplatin and nedaplatin, and was thereby employed to detect platinum drugs in A-549 human lung cancer cells.

AB - A BODIPY-based fluorescent sensor PS with an NO4S2 podand ligand was studied for the selective detection of Pt2+ over 21 cations as well as selected platinum drugs in aqueous medium. The platinum sensor PS shows 28-fold, 22-fold and 14-fold fluorescence turn-on enhancements to Pt2+, cisplatin and nedaplatin, and was thereby employed to detect platinum drugs in A-549 human lung cancer cells.

UR - https://www.scopus.com/pages/publications/85081150696

U2 - 10.1039/d0cc00027b

DO - 10.1039/d0cc00027b

M3 - Journal article

C2 - 32030397

AN - SCOPUS:85081150696

SN - 1359-7345

VL - 56

SP - 2695

EP - 2698

JO - Chemical Communications

JF - Chemical Communications

IS - 18

ER -

A BODIPY-based fluorescent sensor for the detection of Pt²⁺ and Pt drugs

Abstract

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