A bioactivity-guided study on the anti-diarrheal activity of Polygonum chinense Linn

Haitao XIAO, Siu Wai TSANG, Hong Yan Qin, Franky F.K. Choi, Zhijun YANG, Simon Q B HAN, Hubiao CHEN, Hong Xi Xu, Hong Shen, Aiping LYU, Zhaoxiang BIAN*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)

Abstract

Ethnopharmacological relevance Polygonum chinense Linn., a folk medicine, has long been used for the treatment of diarrhea and enteritis in southwestern China. However, the components responsible for its anti-diarrheal activity are still poorly understood. Aim of the study To determine anti-diarrheal activities of Polygonum chinense L. and to identify its active components through bioactivity-guided isolation technique. Materials and methods Animals were orally administered with the extract of Polygonum chinense L. The anti-diarrheal effects of 75% ethanol extract, four fractions with different polarities from 75% ethanol extract, different eluates collected from Diaion HP-20 macroporous resin chromatography, ellagic acid and corilagin, were examined based on mouse models of castor oil- and magnesium sulfate-induced diarrhea. Results The results showed that the 75% ethanol extract of Polygonum chinense L. exhibited significant anti-diarrheal activities in a dose-dependent manner in two mouse models. Through in vivo bioactivity-guided fractionation processes, n-butanol and aqueous fractions were found to exhibit prominent anti-diarrheal activities, and two major compounds, ellagic acid and corilagin, from these active fractions were found to possess anti-diarrheal effects. Conclusion Present study provides evidence of the utilization of Polygonum chinense L. for diarrhea, and ellagic acid and corilagin are two components contributing to the anti-diarrheal effect.

Original languageEnglish
Pages (from-to)499-505
Number of pages7
JournalJournal of Ethnopharmacology
Volume149
Issue number2
DOIs
Publication statusPublished - 16 Sep 2013

Scopus Subject Areas

  • Pharmacology
  • Drug Discovery

User-Defined Keywords

  • Anti-diarrheal activity
  • Corilagin
  • Ellagic acid
  • Polygonum chinense Linn.

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