TY - JOUR
T1 - A 3-in-1 wearable and implantable biopatch for integrated in-body energy harvesting, sensing, and self-powered diabetic wound treatments
AU - Kong, Jianglong
AU - Chu, Runxuan
AU - Mao, Meiru
AU - Yu, Hongrui
AU - Liu, Jiawen
AU - Sun, Yuting
AU - Ge, Xiaohan
AU - Jin, Zixin
AU - Huang, Weimin
AU - Hu, Na
AU - Wang, Yi
N1 - Publisher Copyright:
© 2025 Elsevier Ltd
PY - 2025/4
Y1 - 2025/4
N2 - The integration of energy generators, implantable and wearable sensors, and therapeutic devices holds great promise for the future of health care. In this study, a 3-in-1 multifunctional biopatch (M-BioP) capable of harvesting energy from body and organ movements was developed. M-BioP, which is enhanced with 2D materials, demonstrates excellent output performance and durability, efficiently converting harvested energy into electrical stimulation for sensing and therapeutic applications. M-BioP can promote the migration and proliferation of fibroblasts in vitro. The near-infrared (NIR)-assisted M-BioP exhibited photothermal antibacterial effects on Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa with high efficiency and a long duration. By promoting collagen deposition, angiogenesis, and M2 polarization of macrophages at the wound site, the NIR-assisted M-BioP accelerates the healing of diabetic wounds infected with bacteria; this represents the first instance of an implanted patch for antibacterial therapy as well as in-body energy harvesting, presenting novel opportunities for future medical innovations.
AB - The integration of energy generators, implantable and wearable sensors, and therapeutic devices holds great promise for the future of health care. In this study, a 3-in-1 multifunctional biopatch (M-BioP) capable of harvesting energy from body and organ movements was developed. M-BioP, which is enhanced with 2D materials, demonstrates excellent output performance and durability, efficiently converting harvested energy into electrical stimulation for sensing and therapeutic applications. M-BioP can promote the migration and proliferation of fibroblasts in vitro. The near-infrared (NIR)-assisted M-BioP exhibited photothermal antibacterial effects on Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa with high efficiency and a long duration. By promoting collagen deposition, angiogenesis, and M2 polarization of macrophages at the wound site, the NIR-assisted M-BioP accelerates the healing of diabetic wounds infected with bacteria; this represents the first instance of an implanted patch for antibacterial therapy as well as in-body energy harvesting, presenting novel opportunities for future medical innovations.
KW - Electrical stimulation
KW - In-body energy harvesting and sensing
KW - Photothermal antibacterial
KW - Therapeutic treatment
UR - http://www.scopus.com/inward/record.url?scp=85217256792&partnerID=8YFLogxK
UR - https://www.sciencedirect.com/science/article/pii/S2211285525001028?via%3Dihub
U2 - 10.1016/j.nanoen.2025.110743
DO - 10.1016/j.nanoen.2025.110743
M3 - Journal article
AN - SCOPUS:85217256792
SN - 2211-2855
VL - 136
JO - Nano Energy
JF - Nano Energy
M1 - 110743
ER -
