A 2,7-carbazole-based dicationic salt for fluorescence detection of nucleic acids and two-photon fluorescence imaging of RNA in nucleoli and cytoplasm

Xin Liu, Yuming Sun, Yuanhong Zhang, Fang Miao, Guancong Wang, Hongshi Zhao, Xiaoqiang Yu*, Hong Liu, Wai Yeung WONG

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

66 Citations (Scopus)

Abstract

A new carbazole-derived dicationic compound, namely 2,7-bis(1-hydroxyethyl- 4-vinylpyridinium iodine)-N-ethylcarbazole (2,7-9E-BHVC), with a large two-photon action absorption cross section in nucleic acids has been obtained. Moreover, it possesses the potential of imaging RNA in nucleoli and cytoplasm in two-photon fluorescence microscopy and exhibits good counterstain compatibility with the commercial fluorescent nucleic dye DAPI.

Original languageEnglish
Pages (from-to)3615-3618
Number of pages4
JournalOrganic and Biomolecular Chemistry
Volume9
Issue number10
DOIs
Publication statusPublished - 21 May 2011

Scopus Subject Areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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