3D graphene/hydroxypropyl-β-cyclodextrin nanocomposite as an electrochemical chiral sensor for the recognition of tryptophan enantiomers

Wenting Liang*, Yanqin Rong, Lifang Fan, Wenjuan Dong, Qingchen Dong, Cheng Yang, Zhihui Zhong, Chuan Dong, Shaomin Shuang, Wai Yeung WONG

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

40 Citations (Scopus)

Abstract

A novel and facile chiral sensing platform has been designed for electrochemical enantiomer recognition based on the coupling of three-dimensional-graphene with hydroxypropyl-β-cyclodextrin (3D-G/HP-β-CD). The chiral platform synergistically exploits HP-β-CD as a supramolecular chiral recognizer and 3D-G as an electrochemical indicator, to recognize tryptophan (Trp) enantiomers by differential pulse voltammetry (DPV) approach with significantly discernable electrochemical signals. The different host-guest interactions of d- and l-Trp with HP-β-CD reveal high binding affinity to target l-tryptophan for sensing tryptophan isomers. Moreover, we found that the peak currents of the two enantiomers showed a linear response in the concentration range of 0.5-175 μM with low detection limits of 9.6 nM and 38 nM for l- and d-Trp (S/N = 3), respectively, exhibiting remarkable sensitivity, fine reproducibility as well as great stability. This process, which is the initial demonstration of cyclodextrin-functionalized 3D-G for an electrochemical chiral recognition application, provides a new strategy for enantiosensing.

Original languageEnglish
Pages (from-to)12822-12829
Number of pages8
JournalJournal of Materials Chemistry C
Volume6
Issue number47
DOIs
Publication statusPublished - 2018

Scopus Subject Areas

  • Chemistry(all)
  • Materials Chemistry

Fingerprint

Dive into the research topics of '3D graphene/hydroxypropyl-β-cyclodextrin nanocomposite as an electrochemical chiral sensor for the recognition of tryptophan enantiomers'. Together they form a unique fingerprint.

Cite this