Abstract
目的：将麻黄总提物分为麻黄碱和非麻黄碱两部分，并试验非麻黄碱部分的溶栓作用。方法：用氯仿萃取分离麻黄碱与非麻黄碱部分，氯化铁局灶性脑缺血大鼠模型进行溶栓作用研究。结果：非麻黄碱部分具有与麻黄碱部分及盐酸麻黄碱对照品溶液相当的溶栓作用。结论：非麻黄碱部分可能含有显示麻黄整体药效的有效成分。
OBJECTIVE: To separate the total extract of Ephedra sinica Stapf into two parts, ephedrine alkaloids and non-ephedrine alkaloids, and to investigate if the non-ephedrine alkaloids part has thrombolysis effect. METHODS: Chloroform was used to isolate ephedrine alkaloids and non-ephedrine alkaloids. A cerebral ischemic model of SD mice developed by ferric chloride was applied to test the thrombolysis effect of non-ephedrine alkaloids part. RESULTS: The non-ephedrine alkaloids part had apparent thrombolysis effect. CONCLUSION: There may be some effective components in non-ephedrine alkaloids part which has shown the total pharmacological effect of Ephedra sinica Stapf.
| Translated title of the contribution | Separation of ephedrine alkaloids and non-ephedrine alkaloids in Ephedra sinica and study on thrombolysis effect of non-ephedrine alkaloids |
|---|---|
| Original language | Chinese (Simplified) |
| Pages (from-to) | 423-425 |
| Number of pages | 3 |
| Journal | 中国药学杂志 |
| Volume | 39 |
| Issue number | 6 |
| Publication status | Published - 5 Jun 2004 |
User-Defined Keywords
- 麻黄
- 非麻黄碱部分
- 脑缺血模型
- 溶栓作用
- Cerebral ischemic model
- Ephedra sinica Stapf
- Non-ephedrine alkaloids
- Thrombolysis