鲜鱼腥草酚类化学成分的研究

目的: 研究三白草科Saururaceae蕺菜属植物蕺菜Houttuynia cordata的酚类化学成分。方法: 利用Diaion HP-20, Sephadex LH-20,ODS和硅胶柱色谱进行分离纯化, 根据化合物的理化性质和光谱数据鉴定结构。结果: 分离得到5个化合物,分别鉴定为:绿原酸甲酯(1),4-羟基-4[3′-(β-D-葡萄糖)亚丁基]-3,5,5-三甲基-2-环己稀-1-醇(2),2-(3,4二羟基)-苯乙基-β-D-葡萄糖苷(3),对羟基苯乙醇-β-D-葡萄糖苷(4),4-β-D-葡萄糖-3-羟基苯甲酸(5)。结论: 该5个化合物均为首次从该属及本植物中分离得到。

Objective: To study the aqueous constituents of Houttuynia cordata. Method: Various columns including Diaion HP-20, Sephadex LH-20, ODS and silica gel were employed for the isolation and purification of compounds from H. cordata. The structures of the compounds were identified by physiochemical properties and spectral analysis. Result:; Five compounds were isolated, and their structures were identified as chlorogenic methyl ester (1), (E)-4-Hydroxy-4-[3′- (β-D-glucopyranosyloxy) butylidene]-3, 5, 5-trimethyl-2-cyclohexen-l-one (2), 2-(3, 4-dihydroxyphenyl) ethyl-β-D-glucopyranoside (3), p-hydroxyphenethyl-β-D-glucoside (4), 4-(β-D-glucopyranosyloxy)-3- hydroxy-Benzoic acid (5). Conclusion: All compounds were isolated from this plant for the first time.