贵州冬凌草的对映－贝壳杉烷二萜化合物

从贵州产冬凌草[Isodon rubescens (Hemsl.) Hera]中分离得到12个6，7－断 裂－7，20－内酯－对映－贝壳杉烷二萜化合物，经波谱分析鉴定了它们的结构， 其中有7个新化合物，分别命名为贵州冬凌草乙素～辛素（guidongnins B～H, 1～ 7)，以及卢氏冬凌草甲素（8）、卢氏冬凌草乙素（9）、贵州冬凌草素（10）、狭 叶香茶菜素(angustifolin, 11)和6－表香茶菜素（6-epiangustifolin, 12)等5个 已知化合物。另外，将作者原命名的贵州冬凌草素（guidongnin, 10）更名为贵州 冬凌草甲素(guidongnin A, 10)，并利用二维核磁区振波谱技术修订了卢氏冬凌草 乙素的结构。

Twelve 6, 7-seco-7, 20-olide-ent-kaurane diterpenoids, including seven new compounds named guidongnins B - H (1 - 7) and five known ones identified as ludongnin A (8), ludongnin B (9), guidongnin (10), angustifolin (11) and 6-epiangustifolin (12), were isolated from Isodon rubescens collected in Guizhou Province. On the basis of spectroscopic evidences, the new compounds were elucidated as 16(R)-methyl-6, 7-seco-6, 19; 7, 20-diolide-ent-kaur-15-one (1), 16(R)-methyl-11α-hydroxy-6, 7-seco-6, 19; 7, 20-diolide-ent-kaur-15-one (2), 16 (S)-hydroxymethyl-11α-hydroxy-6, 7-seco-6, 19; 7, 20-diolide-ent-kaur-15-one (3), 16(R)-methyl-6α-hydroxy-6, 7-seco-6, 19-epoxy-7, 20-olide-ent-kaur-15-one (4), 16(R)-methyl-6β-hydroxy-6, 7-seco-6, 19-epoxy-7, 20-olide-ent-kaur-15-one (5), 6β, 15β-dihydroxy-6, 7-seco-6, 19-epoxy-7, 20-olide-ent-kaur-16-ene (6) and 16(R)-methyl-19β-oxymethyl-6, 7-seco-6, 19-epoxy-7, 20-olide-ent-kaur-15- one (7), respectively. The structure of ludongnin B was revised by 2D-NMR spectra and the name of guidongnin (10) was renamed guidongnin A (10).