αvβ3-Isoform specific erbium complexes highly specific for bladder cancer imaging and photodynamic therapy

Yan Zhou; Chi Fai Chan; Daniel W J Kwong; Ga Lai Law; Steven Cobb; Rick Wai Kwok Wong; Ka-Leung Wong

doi:10.1039/c6cc09246b

α_vβ₃-Isoform specific erbium complexes highly specific for bladder cancer imaging and photodynamic therapy

Yan Zhou
, Chi Fai Chan
, Daniel W J Kwong^*
, Ga Lai Law^*
, Steven Cobb
, Rick Wai Kwok Wong^*
, Ka-Leung Wong^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › peer-review

32 Citations (Scopus)

Abstract

We have synthesized a bifunctional erbium-porphyrin tumor imaging and PDT agent (Er-R₃) that is capable of killing bladder cancer cells via its selective binding to the integrin α_vβ₃ isoform overexpressed on the cell membrane.

Original language	English
Pages (from-to)	557-560
Number of pages	4
Journal	Chemical Communications
Volume	53
Issue number	3
Early online date	6 Dec 2016
DOIs	https://doi.org/10.1039/c6cc09246b
Publication status	Published - 11 Jan 2017

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SDG 3 Good Health and Well-being

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10.1039/c6cc09246b

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@article{5d45468d1ff14826a8a1abec7a38a6e1,

title = "αvβ3-Isoform specific erbium complexes highly specific for bladder cancer imaging and photodynamic therapy",

abstract = "We have synthesized a bifunctional erbium-porphyrin tumor imaging and PDT agent (Er-R3) that is capable of killing bladder cancer cells via its selective binding to the integrin αvβ3 isoform overexpressed on the cell membrane.",

author = "Yan Zhou and Chan, \{Chi Fai\} and Kwong, \{Daniel W J\} and Law, \{Ga Lai\} and Steven Cobb and Wong, \{Rick Wai Kwok\} and Ka-Leung Wong",

note = "Funding Information: This work was supported by the Hong Kong Baptist University (HKBU) Faculty Research Grants (FRG2/14-15/013), the Hong Kong Polytechnic University (HKPolyU), the Hong Kong Research Grants Council (HKBU 22301615, Polyu 253002/14P and Polyu 5096/13P) and the HKBU-HKPolyU Joint Research Programme (RC-ICRS/15-16/02F-KLW and RC-ICRS/15-16/02D-DWJK).",

year = "2017",

month = jan,

day = "11",

doi = "10.1039/c6cc09246b",

language = "English",

volume = "53",

pages = "557--560",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "3",

}

TY - JOUR

T1 - αvβ3-Isoform specific erbium complexes highly specific for bladder cancer imaging and photodynamic therapy

AU - Zhou, Yan

AU - Chan, Chi Fai

AU - Kwong, Daniel W J

AU - Law, Ga Lai

AU - Cobb, Steven

AU - Wong, Rick Wai Kwok

AU - Wong, Ka-Leung

N1 - Funding Information: This work was supported by the Hong Kong Baptist University (HKBU) Faculty Research Grants (FRG2/14-15/013), the Hong Kong Polytechnic University (HKPolyU), the Hong Kong Research Grants Council (HKBU 22301615, Polyu 253002/14P and Polyu 5096/13P) and the HKBU-HKPolyU Joint Research Programme (RC-ICRS/15-16/02F-KLW and RC-ICRS/15-16/02D-DWJK).

PY - 2017/1/11

Y1 - 2017/1/11

N2 - We have synthesized a bifunctional erbium-porphyrin tumor imaging and PDT agent (Er-R3) that is capable of killing bladder cancer cells via its selective binding to the integrin αvβ3 isoform overexpressed on the cell membrane.

AB - We have synthesized a bifunctional erbium-porphyrin tumor imaging and PDT agent (Er-R3) that is capable of killing bladder cancer cells via its selective binding to the integrin αvβ3 isoform overexpressed on the cell membrane.

UR - https://www.scopus.com/pages/publications/85008674682

U2 - 10.1039/c6cc09246b

DO - 10.1039/c6cc09246b

M3 - Journal article

C2 - 27973635

AN - SCOPUS:85008674682

SN - 1359-7345

VL - 53

SP - 557

EP - 560

JO - Chemical Communications

JF - Chemical Communications

IS - 3

ER -

α_vβ₃-Isoform specific erbium complexes highly specific for bladder cancer imaging and photodynamic therapy

Abstract

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