αvβ3-Isoform specific erbium complexes highly specific for bladder cancer imaging and photodynamic therapy

Yan Zhou; Chi Fai Chan; Daniel W J Kwong; Ga Lai Law; Steven Cobb; Rick Wai Kwok Wong; Ka-Leung Wong

doi:10.1039/c6cc09246b

α_vβ₃-Isoform specific erbium complexes highly specific for bladder cancer imaging and photodynamic therapy

Yan Zhou, Chi Fai Chan, Daniel W J Kwong^*, Ga Lai Law^*, Steven Cobb, Rick Wai Kwok Wong^*, Ka-Leung Wong^*

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Journal article › peer-review

21 Citations (Scopus)

Abstract

We have synthesized a bifunctional erbium-porphyrin tumor imaging and PDT agent (Er-R₃) that is capable of killing bladder cancer cells via its selective binding to the integrin α_vβ₃ isoform overexpressed on the cell membrane.

Original language	English
Pages (from-to)	557-560
Number of pages	4
Journal	Chemical Communications
Volume	53
Issue number	3
Early online date	6 Dec 2016
DOIs	https://doi.org/10.1039/c6cc09246b
Publication status	Published - 11 Jan 2017

Scopus Subject Areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1039/c6cc09246b

Cite this

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title = "αvβ3-Isoform specific erbium complexes highly specific for bladder cancer imaging and photodynamic therapy",

abstract = "We have synthesized a bifunctional erbium-porphyrin tumor imaging and PDT agent (Er-R3) that is capable of killing bladder cancer cells via its selective binding to the integrin αvβ3 isoform overexpressed on the cell membrane.",

author = "Yan Zhou and Chan, {Chi Fai} and Kwong, {Daniel W J} and Law, {Ga Lai} and Steven Cobb and Wong, {Rick Wai Kwok} and Ka-Leung Wong",

note = "Funding Information: This work was supported by the Hong Kong Baptist University (HKBU) Faculty Research Grants (FRG2/14-15/013), the Hong Kong Polytechnic University (HKPolyU), the Hong Kong Research Grants Council (HKBU 22301615, Polyu 253002/14P and Polyu 5096/13P) and the HKBU-HKPolyU Joint Research Programme (RC-ICRS/15-16/02F-KLW and RC-ICRS/15-16/02D-DWJK).",

year = "2017",

month = jan,

day = "11",

doi = "10.1039/c6cc09246b",

language = "English",

volume = "53",

pages = "557--560",

journal = "Chemical Communications",

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T1 - αvβ3-Isoform specific erbium complexes highly specific for bladder cancer imaging and photodynamic therapy

AU - Zhou, Yan

AU - Chan, Chi Fai

AU - Kwong, Daniel W J

AU - Law, Ga Lai

AU - Cobb, Steven

AU - Wong, Rick Wai Kwok

AU - Wong, Ka-Leung

N1 - Funding Information: This work was supported by the Hong Kong Baptist University (HKBU) Faculty Research Grants (FRG2/14-15/013), the Hong Kong Polytechnic University (HKPolyU), the Hong Kong Research Grants Council (HKBU 22301615, Polyu 253002/14P and Polyu 5096/13P) and the HKBU-HKPolyU Joint Research Programme (RC-ICRS/15-16/02F-KLW and RC-ICRS/15-16/02D-DWJK).

PY - 2017/1/11

Y1 - 2017/1/11

N2 - We have synthesized a bifunctional erbium-porphyrin tumor imaging and PDT agent (Er-R3) that is capable of killing bladder cancer cells via its selective binding to the integrin αvβ3 isoform overexpressed on the cell membrane.

AB - We have synthesized a bifunctional erbium-porphyrin tumor imaging and PDT agent (Er-R3) that is capable of killing bladder cancer cells via its selective binding to the integrin αvβ3 isoform overexpressed on the cell membrane.

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DO - 10.1039/c6cc09246b

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SP - 557

EP - 560

JO - Chemical Communications

JF - Chemical Communications

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