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Keyphrases
Alzheimer's Disease
91%
Tetrandrine
62%
TPC2
58%
Ca2+
58%
Cognitive Deficits
52%
Memory Impairment
50%
Pathogenic Role
45%
β-amyloid Pathology
45%
TPCN2
45%
Two-pore
45%
Autophagosome
45%
Tau Aggregation
45%
Channel Inhibition
45%
Tauopathy
45%
5xFAD
27%
Presenilin
26%
Amyloid Plaques
24%
Lysosome
21%
Lysosomal pH
17%
Tau Clearance
16%
Pathological tau
16%
Memory Function
15%
Transgenic
15%
Lysosomal Ca2+
14%
Alzheimer's Disease Model
14%
Ca2+ Homeostasis
14%
Autophagy Dysfunction
14%
Drug Development
13%
Cathepsin D
13%
AIF1
13%
Vacuolar H+-ATPase (V-ATPase)
13%
Familial Alzheimer's Disease
13%
SQSTM1
13%
Two-pore Channel
11%
Knockdown
10%
Molecular Targets
10%
Plaque Accumulation
10%
Cortical Regions
10%
Gain-of-function
10%
Parahippocampal Region
10%
Western Blotting
8%
Autophagy
8%
Endolysosomal
8%
Microglia
8%
Immunofluorescence Staining
8%
Autophagic
8%
Ca2+ Release
7%
Chemically Induced
7%
Alzheimer's Disease Pathology
7%
Anti-Alzheimer Drugs
7%
Autophagy Vacuoles
6%
TRPML1
6%
Alzheimer's Disease Fibroblasts
6%
ATP6V1B1
6%
Spine Morphology
6%
MCOLN1
6%
Cued Fear Conditioning
6%
Intermittent theta Burst Stimulation (iTBS)
6%
Electrophysiological Measurements
6%
Terminal Fragment
6%
Microtubule-associated Protein tau
6%
Spine Density
6%
PFC Prefrontal Cortex
6%
Iba1
6%
Transmission Electronic Microscopy
6%
Pharmacological Inhibitors
6%
Immunohistochemistry
6%
Secretase
6%
Neuroblastoma SH-SY5Y Cells
6%
Glial Fibrillary Acidic Protein
6%
MAP1LC3B
6%
Bafilomycin A1
6%
Ion Exchanger
6%
Therapeutic Strategies
6%
Carboxyl Terminus
6%
Human Patients
6%
Long-term Potentiation
6%
Microtubule-associated Protein 1 Light Chain 3
6%
Knock
6%
Neurofibrillary Tangles
6%
Behavioral Tests
6%
Macroautophagy
6%
Disease Intervention
6%
Mucolipin
6%
Alzheimer's Disease Treatment
6%
LAMP1
6%
Acidity
6%
LC3B
6%
ATP Synthase
6%
Morris Water Maze
6%
H+-ATPase
6%
Amyloid-β Protein Precursor (AβPP)
6%
LAMP2
6%
Biochemistry, Genetics and Molecular Biology
Autophagy
97%
Tetrandrine
79%
5xFAD Mouse
48%
Amyloid Protein
47%
Calcium Channel
45%
Amyloid Beta
45%
Tau
45%
Animal Model
45%
Lysosome
29%
Cathepsin D
24%
Secretase
24%
Drug Development
24%
Transgenics
24%
V-ATPase
17%
Fibroblast
14%
Two-Pore Channel
14%
Homeostasis
14%
AIF1
11%
PSEN1
11%
Presenilin
11%
Synapsin I
11%
Calcium Signaling
9%
Clinical Trial
9%
Small Interfering RNA
9%
Conditioning
8%
Glial Fibrillary Acidic Protein
5%
MCOLN1
5%
ATP6V1B1
5%
Genetics
5%
Amyloid Precursor Protein
5%
C-Terminus
5%
Bafilomycin
5%
Transmission Electron Microscopy
5%
Tau Protein
5%
Wild Type
5%
ATPase
5%
Sequestosome 1
5%
LAMP1
5%
Light Chain
5%
Microtubule-Associated Protein
5%
Neurofibrillary Tangle
5%
Macroautophagy
5%
Immunofluorescence
5%
Western Blot
5%
Microglia
5%
Neuroscience
Alzheimer's Disease
100%
Autophagy
64%
Tetrandrine
60%
Cognitive Disorder
50%
Memory Disorder
50%
Tauopathy
45%
Calcium Channel
45%
Beta Amyloid
45%
Amyloid Protein
28%
Plaque
20%
Lysosome
19%
V-ATPase
15%
Two-Pore Channel
11%
Cathepsin D
11%
Secretase
11%
AIF1
10%
Presenilin 1
10%
Familial Alzheimer's Disease
10%
Fear Conditioning
9%
Microglia
8%
Immunofluorescence
8%
Western Blot
8%
Staining Technique
8%
Fibroblast
8%
In Vitro
7%
Sequestosome 1
5%
Neuroblastoma
5%
Immunohistochemistry
5%
Amyloid Precursor Protein
5%
Tau Protein
5%
C-Terminus
5%
Macroautophagy
5%
Light Chain
5%
Bafilomycin
5%
Microtubule Associated Protein 1
5%
Glial Fibrillary Acidic Protein
5%
Adenosine Triphosphatase
5%
Prefrontal Cortex
5%
Adeno-Associated Virus
5%
Behavioral Test
5%
Transmission Electron Microscopy
5%
Lysosome Associated Membrane Protein 1
5%
Vertebral Column
5%
Water Maze
5%
Neurofibrillary Tangle
5%