Keyphrases
Aptamer
100%
MicroRNA
85%
Osteoclast
73%
Drug Discovery
71%
Bone Anabolic Effects
47%
Nucleic Acids
46%
Small Molecules
44%
Osteoarthritis
37%
Small-molecule Drug Discovery
35%
Bone Formation
35%
Modification Strategies
35%
Nucleic Acid Aptamer
34%
Argonaute
31%
Binding Affinity
28%
Sclerostin
28%
Target mRNA
27%
Aging
27%
Osteoarthritis Progression
26%
Bone Remodeling
25%
Exosomal
25%
MiR-214-3p
23%
Early Osteoarthritis
23%
Anabolic Effect
23%
MiR-138-5p
23%
Osteoclastic
23%
Genetically Engineered Mice
23%
Bone Phenotype
23%
Therapeutic nucleic Acids
23%
Circulating Proteins
23%
Direct Isolation
23%
Rapid Protocol
23%
Learning Perspective
23%
Osteoprogenitor Cells
23%
Targeted Therapy
23%
Mechanical Stimulation
23%
Bimolecular
23%
Chemically Modified
23%
Nucleic Acid Drug
23%
MiRNA-mRNA Interaction
23%
Long Non-coding RNA (LncRNA)
23%
Migration Inhibitory Factor
23%
Therapeutic Use
23%
Target miRNA
23%
Modified Aptamers
23%
Virtual Screening
23%
Amphiphiles
23%
Aptamer Targeting
23%
Affinity Enhancement
23%
Screening Model
23%
Chemotherapy
23%
Pancreatic Cancer
23%
Web Services
23%
Chondrocytes
23%
Mouse Bone Marrow
23%
Targeting Strategies
23%
Machine Learning
23%
Paclitaxel
23%
Noncovalent Interactions
23%
Deep Learning Methods
23%
Sclerostin Inhibitor
23%
Cathepsin K
23%
MiR-214
23%
Druggability
20%
Therapeutic Target
19%
High Affinity
17%
Monoclonal Antibody
16%
Single Guide RNA (sgRNA)
16%
TIMP-2
16%
Activating Transcription Factor 4 (ATF4)
15%
Mature microRNAs
15%
Modification Approaches
15%
TRAF3
15%
Candidate Small Molecules
15%
Aged Mice
14%
Human Serum Albumin
14%
Small Interfering RNA (siRNA)
13%
Low Molecular Weight
13%
Subchondral Bone Remodeling
12%
Coupling Agent
12%
Protein Expression
12%
Short Half-life
12%
Small Molecule Targeting
11%
RNA Structure
11%
Structural Instability
11%
Pharmacodynamic Properties
11%
Targeting Ligands
11%
Machine Learning Techniques
11%
Unique Functions
11%
Machine Learning Approach
11%
RNA Molecules
11%
Structure-based Screening
11%
Functional Loops
11%
Large Volume
11%
Machine Learning Models
11%
Fluoro
11%
Romosozumab
11%
Targeted Delivery
11%
Osteocyte
10%
Osteoblast
10%
Anterior Cruciate Ligament Transection
9%
Aptamer-drug Conjugates (ApDCs)
9%
Synergistic Interaction
9%
Anabolic Response
8%
Osteoblastic Bone Formation
8%
Artificial Intelligence
8%
Postmenopausal Osteoporosis
8%
Bone Resorption
8%
Musculoskeletal System
8%
Osteoclast Activity
7%
Computational Program
7%
Translational Repression
7%
Cartilage Degeneration
7%
Disease-related
7%
Structural Motif
7%
Neural Network
7%
Drug Target Discovery
7%
Network Approach
7%
In Silico
7%
Mature miRNA
7%
Gene Silencing
7%
Pharmacological Screening
7%
Secondary Structural Elements
7%
Convolutional Neural Network
7%
Target RNA
7%
Small Molecule Drugs
7%
Oligonucleotide Sequence
7%
Renal Filtration
7%
Antibody-based
6%
Exosomes
6%
Quantitative PCR
6%
Bone Histomorphometry
6%
Osteoblastogenesis
6%
Actin
6%
Knock-in Mouse Model
6%
Bone-targeting
5%
Bone Specimen
5%
Mechanical Loading
5%
Mechanoresponsive
5%
Bedridden
5%
Targeted Inhibition
5%
High Cardiovascular Risk
5%
Oral Therapy
5%
Sclerostin Monoclonal Antibody
5%
Concomitant Medications
5%
Bispecific
5%
Compliance Issues
5%
Phosphate Modification
5%
Fluorine Modification
5%
Modification Function
5%
Unlocked nucleic Acid
5%
Naturally Occurring nucleoside
5%
Structural Alterations
5%
Nucleobase Modification
5%
Hindlimb
5%
Diabetes
5%
Small Molecule Inhibitors
5%
Difluoro
5%
Aptamer Applications
5%
Negatively Regulate
5%
Aged Patients
5%
Low-density Lipoprotein Receptor-related Protein 5 (LRP5)
5%
First-in-class
5%
Obesity
5%
C(T)
5%
Phosphorothioate
5%
Acid Phosphate
5%
3D Shape
5%
Cancer Development
5%
Clinical Trials
5%
Co-receptor
5%
Protective Behavior
5%
Cardiovascular Disease
5%
Wnt Signaling Pathway
5%
US FDA
5%
Bone Disease
5%
Single-stranded DNA (ssDNA)
5%
Locked nucleic Acid
5%
Weight Modification
5%
Cathepsin K Inhibition
5%
Odanacatib
5%
Adverse Effects
5%
Human Mesenchymal Stem Cells (hMSCs)
5%
Knockdown
5%
Migration Capacity
5%
Drug Development
5%
Pharmacology, Toxicology and Pharmaceutical Science
Aptamer
87%
Drug Discovery
78%
Nucleic Acid
53%
microRNA 214
47%
Messenger RNA
47%
microRNA
39%
Sclerostin
35%
Argonaute Protein
27%
Osteoarthritis
23%
Drug
23%
Genetically Engineered Mouse Strain
23%
Pancreas Cancer
23%
Cathepsin K
23%
Chemotherapy
23%
Virtual Screening
23%
Paclitaxel
23%
Neoplasm
18%
Human Serum Albumin
17%
Ltvax
17%
Diseases
16%
Tumor Necrosis Factor Receptor Associated Factor 3
15%
Monoclonal Antibody
12%
Cartilage Degeneration
8%
Drug Conjugate
7%
Clinical Trial
6%
Oligonucleotide
6%
Romosozumab
5%
Pharmacokinetic
5%
Single Stranded RNA
5%
Postmenopause Osteoporosis
5%
Medicine and Dentistry
microRNA
51%
Osteoarthritis
47%
Ossification
42%
Osteoclast
36%
Aptamer
34%
Osteoblast
25%
Drug
23%
microRNA 214
23%
Osteoprogenitor Cell
23%
RNA Structure
23%
Targeted Therapy
23%
Long Untranslated RNA
23%
Migration Inhibition Factor
23%
Pancreas Cancer
23%
Nucleic Acid
23%
Sclerostin
23%
Chondrocyte
23%
Hindlimb
15%
Immobility
15%
Monoclonal Antibody
12%
Small Interfering RNA
12%
In Vitro
11%
Actin
11%
Translational Medicine
9%
Cartilage Degeneration
8%
Drug Conjugate
7%
Bone Remodeling
7%
Osteoplasty
7%
Treadmill Exercise
7%
Senile Osteoporosis
7%
Cross-Link
7%
Bone Development
7%
Fibrinogen
7%
Sensitization
7%
Microtubule
7%
Transgenic Mouse
7%
Cancer
6%
Diseases
6%
Exosome
6%
Anterior Cruciate Ligament
5%
Romosozumab
5%
Messenger RNA
5%
Bone Marrow Mesenchymal Stem Cell
5%