The role of Interleukin 24 in regulating ocular inflammation: a novel cytokine for the treatment of autoimmune uveitis

In this project, we propose to investigate the underlying molecular mechanisms by which IL-24 resolves ocular inflammation in EAU via inhibition of the uveitogenic T cells and RPE cells in the eyes. Using nanomaterials, we will design delivery vehicles for targeted transfer of IL-24 to the site of inflammation in the eye. Subsequently, we will translate these observations into the human immunocompetent “eye-on-chip”, a 3D human cell–based in vitro model of the eye. This project is directly related to the research scheme and will provide immediate scientific evidence to support a clinical study of IL-24 as a novel immunotherapy for uveitis.