Keyphrases
FTO Gene
70%
N6-methyladenosine
66%
Demethylation
66%
Associated Proteins
55%
Obesity
55%
Fat Mass
55%
RNA Complexes
50%
Epitranscriptomic Modification
50%
ALKBH5
50%
RNA Epitranscriptomics
50%
2-oxoglutarate
50%
Inhibitor Development
50%
AlkB Homologs
50%
Structure-based Design
50%
Substrate Recognition
50%
2-oxoglutarate-dependent Dioxygenase
38%
M6 A
30%
X-ray Crystallography
26%
AlkB
22%
Erasers
20%
RNA Modification
20%
Binding Mode
20%
Substrate Mimetics
16%
Bacterial Enzymes
16%
Hypoxia-inducible Factor Prolyl Hydroxylase
16%
PHD2
16%
JmjC Histone Demethylase
16%
Aspartate β-hydroxylase
16%
Potent Inhibitor
16%
Anticancer Therapy
16%
Nucleic Acids
16%
Binding Assay
16%
Binding Interaction
16%
Substrate Binding Site
16%
Fe(II)
16%
Hemiaminal
11%
Single-stranded DNA (ssDNA)
11%
Single Guide RNA (sgRNA)
11%
Inhibition Studies
10%
Drug Discovery
10%
Acute Myeloid Leukemia
10%
Structural Information
10%
Atomic Level
10%
Health Research
10%
Non-target Organisms
10%
Gene Regulation
10%
Basic Health
10%
Small Molecule Inhibitors
10%
Cancer Therapy
10%
Anticancer Effect
10%
Brain Cancer
10%
Structural Biology
10%
Blood Cancer
10%
Clinically Significant
10%
Structure-based Approaches
10%
Chemical Biology
10%
3-methyladenine (3-MA)
10%
Macromolecular Crystallography
10%
Chemical Modification
10%
Anticancer Treatment
10%
Viral Replication
10%
Low Toxicity
10%
Third Generation
10%
In Cancer
10%
Human Disease
10%
Chemical Compounds
10%
Physiological Effects
10%
Wide-ranging
10%
Cancer Growth
10%
Glioblastoma
10%
Tumor Progression
10%
Research Discovery
10%
Proton Shuttle
5%
M6A Methylation
5%
Post-transcriptional RNA Modification
5%
Oxidative Enzymes
5%
RNA Substrates
5%
RNA N6-methyladenosine
5%
Demethylate
5%
Ferrous Iron
5%
Active Sites
5%
Consensus Sequence
5%
Regulatory Role
5%
Nucleosides
5%
Sequence Motif
5%
Molecular Mechanism
5%
Biochemical Analysis
5%
Cancer Treatment
5%
Formaldehyde
5%
DNA Substrates
5%
Biochemistry, Genetics and Molecular Biology
RNA
100%
Crystal Structure
75%
Demethylation
66%
N6-Methyladenosine
66%
Oxygenase
60%
Fat Mass
60%
Epitranscriptomics
50%
X-Ray Crystallography
33%
Anticancer
33%
Enzyme
16%
Demethylase
16%
Binding Site
16%
Messenger RNA
16%
Histone
16%
Hypoxia-Inducible Factors
16%
Nucleic Acid
16%
Sequence Motif
10%
Consensus Sequence
10%
Active Site
10%
Oxidoreductase
10%
Single-Stranded DNA
10%
Nucleoside
10%
Virus Replication
8%
Gene Control
8%
Myeloid
8%
Target Cell
8%
Small Molecule
8%
Tumor Progression
8%
Clinical Study
8%
Pharmacology, Toxicology and Pharmaceutical Science
Malignant Neoplasm
60%
2 Oxoglutaric Acid
50%
Alpha Ketoglutarate Dependent Dioxygenase FTO
50%
Oxygenase
20%
Clinical Study
12%
Acute Myeloid Leukemia
12%
Cancer Growth
12%
6 N Methyladenine
12%
Brain Cancer
12%
Glioblastoma
12%
Drug Discovery
12%
Diseases
12%
Tumor Growth
12%
Oxygenase Inhibitor
10%
Bacterial Enzyme
10%
Messenger RNA
10%
6 N Methyladenosine
10%
Histone Demethylase
10%
Binding Site
10%
Nucleic Acid
10%
Hypoxia Inducible Factor
10%
Ferrous Ion
10%
Proline Derivative
10%