Robustness and sloppiness in human brain networks: reliability and variability across individuals, aging and genetic modulations

Project: Research project

Project Details


Human cognitive performance is based on dynamical patterns organized through complex interconnected brain networks which are developed through long time evolution. Recent research has paid much attention to structure-function relationship within brain networks by comparing different groups of participants – mostly persons in pathological conditions compared with typically functioning individuals. However, typically functioning individuals also substantially differ in cognitive behavior, but such individual differences as rooted in the brain’s complex structural and functional networks are only poorly understood to date. Observable individual differences may deeply relate to the evolution principle of a trade-off between evolutionary robustness by developing a reliable structure and function and evolvability through strong enough phenotype variability. Several crucial questions have not yet been well addressed. How reliable and variable are the brain’s structural and functional networks across individuals? Is the reliability/variability uniform or heterogeneous within the network? How is the measured variability related to behavioral differences between individuals? Why some variations in the brain networks lead to typical behavior and others to pathological conditions? How are typical development and aging, and brain disorder and disease related with the brain network reliability and variability? Address these questions is of fundamental importance to understanding brain normal and abnormal functions and developing engineering and medical modulations. Especially, variation in brain disorders and diseases may happen at the extreme ends of the variability spectra, and early detection becomes highly challenging when masked by typical individual differences. It is highly desirable to develop a systematic theoretical/computational framework for interpersonal variability and validate in large samples.

This collaborative project aims to address the above fundamental questions by combining large-scale multimodal brain imaging datasets (~2000 subjects) with computational model in a novel framework of sloppiness in systems biology. Sloppiness refers to an anisotropic parameter space, wherein the system state is highly sensitive to variation along some ‘stiff’ directions (combinations of parameters) and less sensitive in many ‘sloppy’ directions. The possible stiffness and sloppiness in the brain network will be studied using pairwise maximal entropy (Ising) model fitted to the brain resting state spatiotemporal activity patterns measured from functional MRI; The stiffness and sloppiness will be directly compared with actual interindividual reliability and variability of the brain networks measured from MRI across large samples of individuals and used to predict behavior performance. This framework may provide novel approaches to identify fingerprints of individuals in cognitive performance as the combinations of different stiff or sloppy structural links. We will also study how the brain networks change with aging and how these changes are modulated by risk gene APOE ε4 of Alzheimer’s Diseases (AD). We hypothesize that normal aging and atypical neurodegeneration my target network subsets with different stiffness levels. Potential findings in this project may shed fundamentally new lights into the organization and universal working principle of the brain networks underlying stable function and diverse individual differences and contribute to the question of how these principles transfer to the extreme ends of brain disorders. Thus, the project will build foundation for future systematic studies of various types of brain diseases to potentially identify correspondly the most crucial brain components for electrical or magnetic modulations for intervention and prevention in engineering and clinical applications.
Effective start/end date1/10/1931/03/23

UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This project contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being


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