Keyphrases
5xFAD
13%
Acidity
6%
Age-related
11%
AIF1
13%
Alzheimer's Disease
91%
Alzheimer's Disease Fibroblasts
6%
Alzheimer's Disease Model
10%
Alzheimer's Disease Pathology
22%
Alzheimer's Disease Patient
11%
Alzheimer's Disease Prevention
11%
Alzheimer's Disease Treatment
52%
Amyloid Cascade Hypothesis
11%
Amyloid Plaques
17%
Amyloid Precursor Protein
13%
Amyloid-β Protein Precursor (AβPP)
6%
ATP Synthase
6%
ATP6V1B1
6%
Autophagic
8%
Autophagosome
45%
Autophagy
8%
Autophagy Vacuoles
6%
Bafilomycin A1
6%
Behavioral Tests
6%
Biophysical Properties
9%
Ca2+
97%
Ca2+ Channels
11%
Ca2+ Dysregulation
22%
Ca2+ Elevation
45%
Ca2+ Handling
11%
Ca2+ Homeostasis
22%
Ca2+ Release
7%
Ca2+ Stores
6%
Calcium Signaling
45%
Candida Albicans (C. albicans)
45%
Capacitative Ca2+ Entry
32%
Carboxyl Terminus
6%
Cathepsin D
6%
Cause of Disease
6%
Causes of Dementia
11%
Cell Calcium
11%
Cellular Processes
8%
Channel Activity
7%
Channel Characterization
5%
Channel Inhibition
45%
Chemical Agents
11%
Cognitive Deficits
52%
Cognitive Function
15%
Cortical Regions
6%
Cued Fear Conditioning
6%
Cultured Hippocampal Neurons
6%
Current-voltage Relation
5%
Cytoplasmic Ca2+
9%
Cytosolic Ca2+
51%
Dendritic Spines
6%
Dialysis
5%
Disease Intervention
6%
Disease Origin
11%
Disease-associated
45%
Disease-causing mutations
6%
Drug Development
6%
Dysregulation
18%
Electrophysiological Examination
45%
Electrophysiological Measurements
6%
Electrophysiological Properties
5%
Electrophysiology
53%
Endolysosomal
8%
Endoplasmic Reticulum
16%
Familial Alzheimer's Disease
58%
Fura-2
5%
Gain-of-function
6%
Glial Fibrillary Acidic Protein
6%
H+-ATPase
6%
Human Patients
6%
Iba1
6%
Immunofluorescence Staining
8%
Immunohistochemistry
6%
Immunostaining
5%
Innate Immune Response
9%
Innate Immunity
45%
InsP3 Receptors
6%
InsP3R
51%
Interferon Regulatory Factor 3 (IRF3)
9%
Intermittent theta Burst Stimulation (iTBS)
6%
Intracellular Ca2+ Release
6%
Intracellular Organelles
11%
Ion Exchanger
6%
Knock
6%
Knockdown
6%
LAMP1
6%
LAMP2
6%
LC3B
6%
Linear Current
5%
Long-term Potentiation
6%
Lysosomal Ca2+
23%
Lysosomal Calcium
5%
Lysosomal pH
17%
Lysosome
23%
Macroautophagy
6%
MAP1LC3B
6%
MCOLN1
6%
Membrane Patch
5%
Memory Function
8%
Memory Impairment
50%
Microglia
8%
Microtubule-associated Protein 1 Light Chain 3
6%
Microtubule-associated Protein tau
6%
Minimal Manipulation
8%
Molecular Mechanism
11%
Molecular Targets
6%
Morris Water Maze
6%
Most Common Form
11%
Mucolipin
6%
Native Ecosystems
8%
Ned-19
5%
Neuroblastoma SH-SY5Y Cells
13%
Neurofibrillary Tangles
29%
Neuronal Physiology
11%
New Therapies
11%
Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP)
43%
Nuclear Envelope
5%
Nuclear Membrane
48%
Orai Channels
6%
Overexpression
6%
Parahippocampal Region
6%
Patch-clamp Electrophysiology
5%
Patch-clamp Technique
8%
Pathological tau
16%
Patient Fibroblasts
6%
Permeant
5%
PFC Prefrontal Cortex
6%
Phagocytosis
9%
Phagosome
45%
Pharmacological Inhibitors
6%
Physiological Properties
8%
PKA Phosphorylation
8%
Plaque
22%
Plaque Accumulation
6%
Plasma Membrane
14%
Presenilin
72%
Primary Cortical Neurons
6%
Proximate Cause
11%
Ryanodine Receptor
6%
Secretase
52%
Secretase Activity
13%
Signaling Cascades
5%
Single-channel Activity
5%
Single-channel Current
8%
Single-unit Recording
5%
Small Molecules
11%
Spine Density
6%
Spine Morphology
6%
SQSTM1
13%
Store-operated Ca2+ Entry
45%
Stromal Interaction Molecule 1 (STIM1)
45%
Synaptic Dysfunction
11%
Tau Aggregation
45%
Tau Clearance
16%
Tauopathy
45%
Terminal Fragment
6%
Tetrandrine
52%
Therapeutic Approaches
18%
Therapeutic Strategies
6%
TPC2
18%
TPCN2
45%
Transgenic
8%
Transmembrane Domain
6%
Transmission Electronic Microscopy
6%
TRPML1
6%
Two-pore
45%
Two-pore Channel
100%
Vacuolar H+-ATPase (V-ATPase)
13%
Western Blotting
8%
β-amyloid Pathology
45%
Biochemistry, Genetics and Molecular Biology
5xFAD Mouse
11%
AIF1
11%
Amyloid Beta
45%
Amyloid Precursor Protein
18%
Amyloid Protein
20%
Animal Model
45%
ATP6V1B1
5%
ATPase
5%
Autophagy
51%
Bafilomycin
5%
C-Terminus
14%
Calcium Signaling
8%
Candida albicans
45%
Cathepsin D
5%
Complex Formation
9%
Conditioning
8%
Dendritic Spine
6%
Electric Potential
5%
Electrophysiology
51%
Exocyst
9%
Fibroblast
12%
Fura-2
5%
Genetics
5%
Glial Fibrillary Acidic Protein
5%
Hippocampal Neuronal Culture
6%
Homeostasis
14%
Immune Response
9%
Immunofluorescence
14%
Immunostaining
5%
Innate Immunity
45%
Inositol 1,4,5 Trisphosphate Receptor
9%
Interferon Type I
9%
IRF3
18%
Kinase
45%
LAMP1
5%
Light Chain
5%
Lysosome
23%
Macroautophagy
5%
Macrophage
9%
MCOLN1
5%
Memory
5%
Microglia
5%
Microtubule-Associated Protein
5%
Neurofibrillary Tangle
5%
Nicotinic Acid Adenine Dinucleotide Phosphate
43%
Nomenclature
5%
Nuclear Membrane
48%
Nuclear Pore
48%
Patch Clamp
14%
Phagocytosis
18%
Phosphotransferase
45%
Presenilin
57%
PSEN1
11%
Ryanodine Receptor
6%
Secretase
51%
Sequestosome 1
5%
STIM1
45%
Synapsin I
11%
Tau
45%
Tau Protein
5%
Tetrandrine
51%
Transgenics
5%
Transmembrane Domain
6%
Transmembrane Protein
5%
Transmission Electron Microscopy
5%
Two-Pore Channel
97%
V-ATPase
17%
Western Blot
5%
Wild Type
5%
Neuroscience
Adeno-Associated Virus
5%
Adenosine Triphosphatase
5%
AIF1
10%
Alzheimer's Disease
100%
Amyloid Precursor Protein
18%
Amyloid Protein
29%
Autophagy
49%
Bafilomycin
5%
Behavioral Test
5%
Beta Amyloid
45%
C-Terminus
5%
Calcium Channel
8%
Calcium Signaling
54%
Cathepsin D
5%
Cell Line
8%
Cell Membrane
8%
Cleft
6%
Cognitive Disorder
50%
Cognitive Function in Alzheimer's Disease
5%
Dendritic Spine
6%
Electrophysiology
53%
Endoplasmic Reticulum
16%
Familial Alzheimer's Disease
56%
Fear Conditioning
9%
Fibroblast
11%
Glial Fibrillary Acidic Protein
5%
Immunofluorescence
8%
Immunohistochemistry
10%
Light Chain
5%
Lysosome
25%
Lysosome Associated Membrane Protein 1
5%
Macroautophagy
5%
Memory
8%
Memory Disorder
50%
Microglia
8%
Microtubule Associated Protein 1
5%
Neuroblastoma
11%
Nicotinic Acid Adenine Dinucleotide Phosphate
43%
Nuclear Pore
48%
Patch Clamp
14%
Prefrontal Cortex
5%
Presenilin
13%
Presenilin 1
56%
Receptor
14%
Ryanodine Receptor
6%
Secretase
50%
Sequestosome 1
5%
Staining Technique
8%
Tau Protein
5%
Tauopathy
45%
Tetrandrine
50%
Transmission Electron Microscopy
5%
Two-Pore Channel
100%
V-ATPase
15%
Vertebral Column
5%
Water Maze
5%
Western Blot
8%