Keyphrases
Aptamer
100%
MicroRNA
80%
Osteoclast
73%
Bone Formation
68%
Osteoblast
60%
Delivery System
55%
Targeted Delivery System
53%
Small Interfering RNA (siRNA)
50%
Antibody-drug Conjugate
44%
RNA Interference
43%
Therapeutic Genome Editing
43%
Exosomal
43%
Osteosarcoma
43%
Skeletal Disorders
36%
Lipid Nanoparticles
34%
Osteogenic
34%
Targeted Drug Delivery
34%
Linker
32%
Chemical Modification
30%
Osteoblastic Bone Formation
30%
Exosomes
27%
Bone Anabolic Effects
27%
Aging
27%
Molecular Mechanism
26%
Molecular Therapy
25%
Bone Destruction
25%
SELEX
24%
Tumor Cells
24%
Bone Resorption
23%
Small Molecules
22%
Hypoxia-inducible factor-1α (HIF-1α)
21%
Vascularization
21%
Src Inhibitor
21%
Leflunomide
21%
Rheumatoid Arthritis
21%
Src Inhibition
21%
Bone Erosion
21%
Genetically Engineered Mice
21%
Argonaute
21%
Bone Phenotype
21%
Therapeutic Modulation
21%
Lipopolymer
21%
Osteoblastic
21%
Age-related Osteoporosis
21%
Smurf1
21%
Translational Therapy
21%
Prodrug Strategy
21%
Nuclease
21%
Bone Anabolic Therapy
21%
Nanoparticle Targeting
21%
Molecular Communication
21%
Myokines
21%
Osteoprogenitor Cells
21%
Therapeutic Goals
21%
Bone Remodeling
21%
MiR-214-3p
21%
Skeletal muscle
21%
Vascular Endothelial Growth Factor
21%
Nucleic Acid Aptamer
21%
Bone Metabolism
21%
Screening Model
21%
Cas9 Protein
21%
Single-stranded DNA (ssDNA)
21%
Cathepsin K
21%
Breast Cancer
21%
Drug Discovery
21%
Human Epidermal Growth Factor Receptor 2 (HER2)
21%
Cell Delivery
21%
Long Non-coding RNA (LncRNA)
21%
Migration Inhibitory Factor
21%
Virtual Screening
21%
Molecular Targeted Therapy
21%
Mouse Model
21%
In Vivo Delivery
21%
Chondrocytes
21%
Osteoarthritis Progression
21%
Paclitaxel
21%
MiR-214
21%
Genome Editing
21%
Bone Morphogenetic Protein
17%
Therapeutic Efficacy
16%
Osteosarcoma Targeting
16%
Bone Cells
15%
Size Separation
15%
Angiogenesis
14%
Bone Morphogenetic protein-2 (BMP-2)
14%
Delivery Strategy
14%
Programmable nucleases
14%
Activating Transcription Factor 4 (ATF4)
14%
Targeted Cells
14%
TRAF3
14%
Cytotoxic Drugs
13%
Antagomir
13%
Anti-vascular Endothelial Growth Factor (anti-VEGF)
12%
Clinical Trials
12%
Targeted Therapy
12%
Magnetic Separation
12%
Osteoarthritis
12%
Liposomes
11%
Protein Expression
11%
Targeted Delivery
10%
Small Molecule Targeting
10%
Spinal Fusion
10%
Chalcone Derivatives
10%
Binding Protein
10%
Nuclease Degradation
10%
Renal Filtration
10%
Myostatin
10%
Technological Progress
10%
Lung Metastasis
10%
High Chemical Stability
10%
Therapeutic Use
10%
Drug Candidates
10%
Immunogenicity
10%
Clinical Treatment
10%
Chemical Synthesis
10%
Binding Affinity
10%
Two-level
10%
Systemic Administration
10%
Clinical Translation
9%
Cellular Level
9%
Human Mesenchymal Stem Cells (hMSCs)
8%
Glucocorticoid-induced Osteoporosis
8%
Aged Mice
7%
Local Bone
7%
Complex Disturbance
7%
Specific Drug Delivery
7%
Bone Matrix
7%
Targeted Nanoparticles
7%
Skeletal Development
7%
Non-skeletal Tissues
7%
Bone Mineral
7%
Targeting Moieties
7%
Skeletal Growth
7%
Skeletal Homeostasis
7%
Candidate Small Molecules
7%
Osteoclast Activity
7%
Orthotopic Osteosarcoma
7%
Bone Morphogenetic Protein Signaling
7%
Genome-editing nucleases
7%
Meganucleases
7%
Target Organism
7%
Zinc Finger nuclease
7%
TALEN
7%
Endosomal Escape
7%
Negative Charge
7%
Genetic mutation
7%
Drug Loading Capacity
7%
Penetrating Ability
7%
Cancer Treatment
7%
Clinical Potential
7%
Genome Sequencing
7%
Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)
7%
Pathological Tissue
7%
Paracrine
7%
Toxic Effects
7%
Drug Efficacy
7%
High Dose
7%
Integral Component
7%
Specific Delivery
6%
Tissue Level
6%
Rodents
6%
Precision Medicine
6%
Tumor
6%
Double Strand
6%
Recovery Rate
6%
PCR Products
6%
Separation Techniques
6%
Conjugated System
6%
Structural Modification
6%
Therapeutic Strategies
6%
Hepatocytes
5%
Osteoblastogenesis
5%
Bone Mass
5%
Cell-SELEX
5%
Gene Silencing
5%
Arthritic Rats
5%
Therapy Strategy
5%
A77 1726
5%
Potent Drugs
5%
Amine-thiol
5%
Destructive Potential
5%
MiR-148a
5%
Hydroxyapatite
5%
Molecule Modification
5%
Low Selectivity
5%
Solubility Selectivity
5%
Metastatic Osteosarcoma
5%
Intensive Chemotherapy
5%
Bone Cancer
5%
Treatment Regime
5%
Primary Osteosarcoma
5%
Pulmonary Metastasis
5%
Follistatin
5%
Osteoglycin
5%
Endocrine Glands
5%
Interleukin-15 (IL-15)
5%
Interleukin-7 (IL-7)
5%
Insulin-like
5%
Irisin
5%
Pharmacology, Toxicology and Pharmaceutical Science
Aptamer
86%
microRNA
53%
Bone Disease
51%
Neoplasm
45%
Osteosarcoma
43%
Messenger RNA
39%
Targeted Drug Delivery
28%
Nuclease
28%
Bone Destruction
24%
Drug Delivery System
23%
Antibody Drug Conjugate
21%
Vasculotropin
21%
Breast Cancer
21%
Nucleic Acid
21%
Virtual Screening
21%
Cytokine
21%
Vasculotropin A
21%
Receptor
21%
Rheumatoid Arthritis
21%
Inflammatory Arthritis
21%
Bone Erosion
21%
Leflunomide
21%
Drug Discovery
21%
Myostatin
21%
Argonaute Protein
21%
microRNA 214
21%
Genetically Engineered Mouse Strain
21%
Binding Protein
21%
Small Interfering RNA
21%
Cytotoxic Agent
21%
Leporidae
21%
Paclitaxel
21%
Cathepsin K
21%
Prodrug
21%
Combination Therapy
18%
Tumor Necrosis Factor Receptor Associated Factor 3
14%
Liposome
13%
Solid Lipid Nanoparticle
13%
Antagomir
12%
Lung Metastasis
11%
Interleukin Derivative
10%
Interleukin 6
10%
Interleukin 15
10%
Interleukin 7
10%
Follistatin
10%
Irisin
10%
Decorin
10%
Somatomedin C
10%
Malignant Neoplasm
9%
Diseases
8%
Clinical Trial
8%
Chemical Stability
7%
Immunogenicity
7%
Systemic Administration
7%
Nanoparticle
7%
Toxicity
7%
Hydroxyapatite
6%
Monoclonal Antibody
5%
Cytotoxicity
5%
Alcohol Derivative
5%
Azide
5%
Pharmacokinetic
5%
Biodistribution
5%
Teriflunomide
5%
Bone Necrosis
5%
Thiol
5%
Medicine and Dentistry
Ossification
51%
Aptamer
43%
Genome Editing
43%
Osteoblast
30%
Small Interfering RNA
29%
Bone Disease
28%
Exosome
27%
Molecular Therapy
25%
Osteoclast
25%
microRNA
25%
Clustered Regularly Interspaced Short Palindromic Repeat
25%
Cas9
25%
Bone Destruction
24%
Osteoporosis
23%
Bone Morphogenetic Protein
21%
Src Inhibitor
21%
Vasculotropin A
21%
Nuclease
21%
RNAI
21%
Myokine
21%
Osteoprogenitor Cell
21%
Bone Remodeling
21%
Breast Cancer
21%
Vasculotropin
21%
Skeletal Muscle
21%
Vascularity
21%
Tumor Cell
21%
Receptor
21%
Long Untranslated RNA
21%
Migration Inhibition Factor
21%
Osteosarcoma
21%
Chondrocyte
21%
Osteoarthritis
21%
Nanoparticle
20%
Combination Therapy
16%
Angiogenesis
12%
Myostatin
10%
Protein Binding
10%
Cytokine
10%
Systemic Administration
10%
Bone Development
10%
Spinal Fusion
9%
Chalcone Derivative
9%
Bone Morphogenetic Protein 2
9%
Lung Metastasis
9%
Bone Mineral
7%
Bone Matrix
7%
Drug Megadose
7%
Toxicity
7%
Homeostasis
7%
In Vitro
6%
Bone Necrosis
6%
Cancer Therapy
6%
Signaling Protein
6%
Neoplasm
6%
Secretion (Process)
6%
Hepatocyte
5%
Messenger RNA
5%
Interleukin 7
5%
Interleukin 15
5%
Interleukin Derivative
5%
Somatomedin C
5%
Decorin
5%
Follistatin
5%
Irisin
5%
Interleukin 6
5%