基於miR-34b/MET/β-catenin通路探討四君子湯與達卡吧嗪合用抗黑色素瘤的機制

  • YU, Zhiling (PI)
  • Li, Su Mei (CoI)
  • FU, Xiuqiong (CoI)
  • AMIN, Aftab (CoI)
  • Zhao, Jing (CoI)
  • WANG, Yaping (CoI)
  • LIU, Yuxi (CoI)

Project: Research project

Project Details

Description

惡性黑色素瘤是最致命的癌症之一。達卡吧嗪(DTIC)是轉移性黑色素瘤的一線化療藥,但其毒性嚴重製約了臨床應用。四君子湯(SJZT)加減常用於輔助癌症化療。本課題組前期研究發現,SJZT對DTIC有減毒增效的作用,其機制可能與上調miR-34b,下調MET(miR-34b靶基因)及β-連環蛋白(β-catenin,MET下游分子)有關。基於此,我們推測miR-34b/MET/β-catenin通路在SJZT輔助DTIC抗黑色素瘤中起重要作用。本研究將(1)在動物模型上進一步研究SJZT/DTIC抗黑色素瘤作用;(2)在細胞模型上研究調控miR-34b/MET/β-catenin通路在SJZT/DTIC抗黑色素瘤作用中的貢獻;(3)比較不同遺傳背景人源黑色素瘤細胞對SJZT/DTIC的敏感性。這將為研發SJZT成為DTIC治療黑色素瘤的輔助藥物提供藥理基礎。
StatusFinished
Effective start/end date1/01/1931/12/22

UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This project contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

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