Projects per year
Personal profile
Chinese Name
翟李翔
Research Interests
Dr. Lixiang ZHAI has established a prolific academic and research trajectory focusing on the interactions between gut microbiota and Chinese Medicine in basic and clinical studies of functional bowel disorders, metabolic disorders and aging.
1. Investigation of gut microbiota in the development and treatment of non-communicable diseases including functional gastrointestinal disorders, metabolic disorders and aging.
2. Investigation of Chinese medicine and food supplements for the treatment of functional gastrointestinal disorders, metabolic disorders and aging.
Biography
Dr. Lixiang Zhai completed his Bachelor of Science in Pharmacy in Chinese Medicine at Guangdong Pharmaceutical University in 2015, followed by a Ph.D. in Chinese Medicine from Hong Kong Baptist University in 2021. He underwent postdoctoral training at the Centre for Chinese Herbal Medicine Drug Development Limited (@InnoHK) from 2021 to 2022 and currently holds the position of Assistant Professor at the same institution since 2024.
Dr. Zhai's research is at the forefront of understanding the intricate interactions between the host and gut microbiota, which are pivotal in the development of functional bowel disorders, metabolic syndrome, and aging. His focus extends to the clinical translation of Chinese medicine for treating these diseases, demonstrating a commitment to bridging traditional remedies with contemporary medical practices.
Having contributed to prestigious journals like Cell Host & Microbe, Nature Metabolism, Nature Communications, The Journal of Clinical Investigation, ISMEJ, Pharmacological Research, MedComm, Phytomedicine, Phytotherapy Research and others, Dr. Zhai's publications underscore his significant impact on the fields of microbiota research and Chinese medicine. His work not only enriches the scientific community's understanding but also paves the way for novel therapeutic approaches in gastrointestinal and metabolic healthcare.
Keywords
- RM Therapeutics. Pharmacology
- QP Physiology
- RS Pharmacy and materia medica
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Dive into the research topics where Lixiang ZHAI is active. Topic labels come from the works of this scholar.
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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基于油酰乙醇胺-PPARα-p38 MAPK信号轴研究直肠真杆菌Eubacterium rectale抑制血清素合成改善腹泻型肠道易激综合征的作用机制
ZHAI, L. (PI)
1/01/26 → 31/12/28
Project: Research project
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Improved Metabolic Network Reconstruction and Metabolite Profiles Prediction using Complete and Strain-Resolved Microbial Genomes
ZHANG, L. (PI), BIAN, Z. (CoPI), ZHAI, L. (CoPI), Li, S. (CoPI) & Li, J. (CoPI)
30/06/24 → 31/05/27
Project: Research project
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肠道微生物芳香族氨基酸脱羧酶失调对肠易激综合征的腹痛症状和焦虑情绪的影响和机制研究
ZHAI, L. (PI), BIAN, Z. (CoI), WONG, H. L. X. (CoI), XU, S. (CoI) & BAO, G. (CoI)
1/01/24 → 31/12/26
Project: Research project
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Pharmacodynamic and mechanism study of Lingzhi-Jianghuang Formula (LJF) extract on NAFLD in mice
BIAN, Z. (PI), LIN, C. (CoI), QIN, H. (CoI), LIU, Q. (CoI) & ZHAI, L. (CoI)
3/01/24 → 2/01/25
Project: Research project
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Gut microbiota-derived tryptamine and phenethylamine impair insulin sensitivity in metabolic syndrome and irritable bowel syndrome
Zhai, L., Xiao, H., Lin, C., Wong, H. L. X., Lam, Y. Y., Gong, M., Wu, G., Ning, Z., Huang, C., Zhang, Y., Yang, C., Luo, J., Zhang, L., Zhao, L., Zhang, C., Lau, J.Y.-N., Lu, A., Lau, L.-T., Jia, W. & Zhao, L. & 1 others, , 17 Aug 2023, In: Nature Communications. 14, 1, 14 p., 4986.Research output: Contribution to journal › Journal article › peer-review
Open Access -
Ruminococcus gnavus plays a pathogenic role in diarrhea-predominant irritable bowel syndrome by increasing serotonin biosynthesis
Zhai, L., Huang, C., Ning, Z., Zhang, Y., Zhuang, M., Yang, W., Wang, X., Wang, J., Zhang, L., Xiao, H., Zhao, L., Asthana, P., Lam, Y. Y., Chow, C. F. W., Huang, J. D., Yuan, S., Chan, K. M., Yuan, C. S., Lau, J. Y. N. & Wong, H. L. X. & 1 others, , 11 Jan 2023, In: Cell Host and Microbe. 31, 1, p. 33-44, e1-e5 18 p.Research output: Contribution to journal › Journal article › peer-review
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Artesunate treats obesity in male mice and non-human primates through GDF15/GFRAL signalling axis
Guo, X., Asthana, P., Zhai, L., Cheng, K. W., Gurung, S., Huang, J., Wu, J., Zhang, Y., Mahato, A. K., Saarma, M., Ustav, M., Kwan, H. Y., Lyu, A., Chan, K. M., Xu, P., Bian, Z. X. & Wong, H. L. X., 3 Feb 2024, In: Nature Communications. 15, 1, 14 p., 1034.Research output: Contribution to journal › Journal article › peer-review
Open Access -
Body weight regulation via MT1-MMP-mediated cleavage of GFRAL
Chow, C. F. W., Guo, X., Asthana, P., Zhang, S., Wong, S. K. K., Fallah, S., Che, S., Gurung, S., Wang, Z., Lee, K. B., Ge, X., Yuan, S., Xu, H., Ip, J. P. K., Jiang, Z., Zhai, L., Wu, J., Zhang, Y., Mahato, A. K. & Saarma, M. & 7 others, , 17 Feb 2022, In: Nature Metabolism. 4, 2, p. 203–212 10 p.Research output: Contribution to journal › Journal article › peer-review
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A Clostridia-rich microbiota enhances bile acid excretion in diarrhea-predominant irritable bowel syndrome
Zhao, L., Yang, W., Chen, Y., Huang, F., Lu, L., Lin, C., Huang, T., Ning, Z., Zhai, L., Zhong, L. L. D., Lam, W., Yang, Z., Zhang, X., Cheng, C., Han, L., Qiu, Q., Shang, X., Huang, R., Xiao, H. & Ren, Z. & 8 others, , 2 Jan 2020, In: Journal of Clinical Investigation. 130, 1, p. 438-450 13 p.Research output: Contribution to journal › Journal article › peer-review
Open Access
Prizes
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7th Innovation & Entrepreneurship Contest of Chinese Medical Sciences - Third prize
ZHAI, L. (Recipient), 27 Oct 2025
Prize
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China (Shanghai) International Invention and Innovation Exhibition - Silver Medal
ZHAI, L. (Recipient), 13 Jun 2025
Prize
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