Projects per year
Personal profile
Chinese Name
翟李翔
Research Interests
Dr. Lixiang ZHAI focuses on the interplay between Gut Microbiota and Chinese Medicine in basic and clinical research on Disorders of Gut-Brain Interactions (DGBI), metabolic disorders, and aging.
Biography
Dr. Lixiang Zhai completed his Bachelor of Science in Pharmacy in Chinese Medicine at Guangdong Pharmaceutical University in 2015, followed by a Ph.D. in Chinese Medicine from Hong Kong Baptist University in 2021. He underwent postdoctoral training at the Centre for Chinese Herbal Medicine Drug Development Limited (@InnoHK) from 2021 to 2022 and currently holds the position of Assistant Professor at the same institution since 2024.
Having contributed to prestigious journals like Cell Host & Microbe, Nature Metabolism, Nature Communications, The Journal of Clinical Investigation, ISMEJ, Pharmacological Research, MedComm, Phytomedicine, Phytotherapy Research and others, Dr. Zhai's publications underscore his significant impact on the fields of microbiota research and Chinese medicine.
Keywords
- RM Therapeutics. Pharmacology
- RS Pharmacy and materia medica
- R Medicine (General)
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Dive into the research topics where Lixiang ZHAI is active. Topic labels come from the works of this scholar.
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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基于油酰乙醇胺-PPARα-p38 MAPK信号轴研究直肠真杆菌Eubacterium rectale抑制血清素合成改善腹泻型肠道易激综合征的作用机制
ZHAI, L. (PI)
1/01/26 → 31/12/28
Project: Research project
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Improved Metabolic Network Reconstruction and Metabolite Profiles Prediction using Complete and Strain-Resolved Microbial Genomes
ZHANG, L. (PI), BIAN, Z. (CoPI), ZHAI, L. (CoPI), Li, S. (CoPI) & Li, J. (CoPI)
30/06/24 → 31/05/27
Project: Research project
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肠道微生物芳香族氨基酸脱羧酶失调对肠易激综合征的腹痛症状和焦虑情绪的影响和机制研究
ZHAI, L. (PI), BIAN, Z. (CoI), WONG, H. L. X. (CoI), XU, S. (CoI) & BAO, G. (CoI)
1/01/24 → 31/12/26
Project: Research project
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Pharmacodynamic and mechanism study of Lingzhi-Jianghuang Formula (LJF) extract on NAFLD in mice
BIAN, Z. (PI), LIN, C. (CoI), QIN, H. (CoI), LIU, Q. (CoI) & ZHAI, L. (CoI)
3/01/24 → 2/01/25
Project: Research project
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Gut bacteria that produce fatty acid ethanolamides alleviate diarrhea-predominant IBS with insulin resistance
Xu, S. (Co-first author), Lyu, J. (Co-first author), Bao, G. (Co-first author), Zheng, P., Li, Y., Ning, Z., Li, B., Zhuang, M., Wong, H. K., Wang, M., Zeng, Y., Zheng, Y., Luo, J., Liu, Q., Zhang, L., Lin, C., Xiao, H., Yuan, C.-S., Wong, H. L. X. & Bian, Z. & 1 others, , 8 Jul 2026, In: Cell Host and Microbe. 34, 7, p. 1350-1366.e8Research output: Contribution to journal › Journal article › peer-review
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Ruminococcus gnavus plays a pathogenic role in diarrhea-predominant irritable bowel syndrome by increasing serotonin biosynthesis
Zhai, L., Huang, C., Ning, Z., Zhang, Y., Zhuang, M., Yang, W., Wang, X., Wang, J., Zhang, L., Xiao, H., Zhao, L., Asthana, P., Lam, Y. Y., Chow, C. F. W., Huang, J. D., Yuan, S., Chan, K. M., Yuan, C. S., Lau, J. Y. N. & Wong, H. L. X. & 1 others, , 11 Jan 2023, In: Cell Host and Microbe. 31, 1, p. 33-44, e1-e5 18 p.Research output: Contribution to journal › Journal article › peer-review
174 Citations (Scopus) -
Gut microbiota-derived tryptamine and phenethylamine impair insulin sensitivity in metabolic syndrome and irritable bowel syndrome
Zhai, L., Xiao, H., Lin, C., Wong, H. L. X., Lam, Y. Y., Gong, M., Wu, G., Ning, Z., Huang, C., Zhang, Y., Yang, C., Luo, J., Zhang, L., Zhao, L., Zhang, C., Lau, J.Y.-N., Lu, A., Lau, L.-T., Jia, W. & Zhao, L. & 1 others, , 17 Aug 2023, In: Nature Communications. 14, 1, 14 p., 4986.Research output: Contribution to journal › Journal article › peer-review
Open Access110 Citations (Scopus) -
Body weight regulation via MT1-MMP-mediated cleavage of GFRAL
Chow, C. F. W., Guo, X., Asthana, P., Zhang, S., Wong, S. K. K., Fallah, S., Che, S., Gurung, S., Wang, Z., Lee, K. B., Ge, X., Yuan, S., Xu, H., Ip, J. P. K., Jiang, Z., Zhai, L., Wu, J., Zhang, Y., Mahato, A. K. & Saarma, M. & 7 others, , 17 Feb 2022, In: Nature Metabolism. 4, 2, p. 203–212 10 p.Research output: Contribution to journal › Journal article › peer-review
32 Citations (Scopus) -
A Clostridia-rich microbiota enhances bile acid excretion in diarrhea-predominant irritable bowel syndrome
Zhao, L., Yang, W., Chen, Y., Huang, F., Lu, L., Lin, C., Huang, T., Ning, Z., Zhai, L., Zhong, L. L. D., Lam, W., Yang, Z., Zhang, X., Cheng, C., Han, L., Qiu, Q., Shang, X., Huang, R., Xiao, H. & Ren, Z. & 8 others, , 2 Jan 2020, In: Journal of Clinical Investigation. 130, 1, p. 438-450 13 p.Research output: Contribution to journal › Journal article › peer-review
Open Access166 Citations (Scopus)
Prizes
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7th Innovation & Entrepreneurship Contest of Chinese Medical Sciences - Third prize
ZHAI, L. (Recipient), 27 Oct 2025
Prize
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China (Shanghai) International Invention and Innovation Exhibition - Silver Medal
ZHAI, L. (Recipient), 13 Jun 2025
Prize
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