Projects per year
Personal profile
Chinese Name
Biography
Research in my laboratory can be broadly classified into the following two categories
Mechanism of postzygotic hybrid incompatibilities between nematode species
Hybrid incompatibility (HI), including sterility and lethality between closely related species has been noticed over a century ago, but only recently is it possible to decipher the molecular basis of speciation. However, C. elegans has not been explored for such research because there is no sister species found with which it mates and produce hybrid viable progeny. C. briggsae is the closest living relative of C. elegans. We are trying to develop new tools and resources to make C. briggsae and its newly isolated sister species, C. nigoni, as an attractive model system for research into molecular mechanisms of hybrid incompatibility.
Gene regulatory networks underlying cell fate determination during nematode embryogenesis
During C. elegans embryogenesis, the developmental potential of the fertilized egg is restricted in a stepwise manner following each cell division by differentially expressing a cohort of regulatory proteins. Together with the genetic and genomic tools, especially CHIP-Seq, we have been using automatic lineagingto dissect the gene regulatory network underlying the tissue/organ formation.
Research Interests
- Mechanism of postzygotic hybrid incompatibilities between nematode species
- Developmental dynamics of signaling pathways during nematode embryogenesis
- Gene regulatory networks underlying cell fate determination during nematode embryogenesis
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
External positions
1 Jul 2021 → …
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Characterizing the in vivo functions of cyclin L and its binding partners in pre-mRNA splicing and cell cycle control
1/01/21 → 31/12/23
Project: Research project
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Development of an automated system for super resolution microscopy and image processing with enhanced sensitivity
1/07/23 → 30/06/25
Project: Research project
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Roles of chromatin architecture in allele-specific expression and male sterility in species hybrids 染色質結構在種間雜交體的等位基因差异表達和雄性不育中的作用
1/01/19 → 31/12/22
Project: Research project
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Evaluation of nanoplastics toxicity in the soil nematode Caenorhabditis elegans by iTRAQ-based quantitative proteomics
Huang, G., Ma, Y., Xie, D., Zhao, C., Zhu, L., Xie, G., Wu, P., Wang, W., Zhao, Z. & Cai, Z., 1 Mar 2023, In: Science of the Total Environment. 862, 160646.Research output: Contribution to journal › Article › peer-review
3 Citations (Scopus) -
High-throughput profiling of RNA modifications by ultra-performance liquid chromatography coupled to complementary mass spectrometry: Methods, quality control, and applications
Huang, G., Zhang, F., Xie, D., Ma, Y., Wang, P., Cao, G., Chen, L., Lin, S., Zhao, Z. & Cai, Z., 1 Oct 2023, In: Talanta. 263, 124697.Research output: Contribution to journal › Article › peer-review
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Computable early Caenorhabditis elegans embryo with a phase field model
Kuang, X., Guan, G., Wong, M-K., Chan, L-Y., Zhao, Z., Tang, C. & Zhang, L., 14 Jan 2022, In: PLoS Computational Biology. 18, 1, 32 p., e1009755.Research output: Contribution to journal › Article › peer-review
Open Access5 Citations (Scopus) -
Computational modeling and analysis of the morphogenetic domain signaling networks regulating C. elegans embryogenesis
Niu, B., Bach, T. N., Chen, X., Chandratre, K. R., Murray, J. I., Zhao, Z. & Zhang, M., 12 Jul 2022, In: Computational and Structural Biotechnology Journal. 20, p. 3653-3666 14 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Delineating the mechanisms and design principles of Caenorhabditis elegans embryogenesis using in toto high-resolution imaging data and computational modeling
Guan, G., Zhao, Z. & Tang, C., 6 Oct 2022, In: Computational and Structural Biotechnology Journal. 20, p. 5500-5515 16 p.Research output: Contribution to journal › Review article › peer-review
Open Access