Professor Zhang is a faculty member at the School of Chinese Medicine, Hong Kong Baptist University, with over 30 years of research experience in the isolation, identification, structural elucidation, analysis, synthesis, and biological evaluation of small molecules derived from natural products. His work has led to the publication of more than 190 peer-reviewed papers and the granting of numerous patents. Professor Zhang's current research focuses on drug discovery and development from natural resources, as well as the creation of botanical dietary supplements from herbal medicines. He is particularly interested in identifying natural lead compounds from plants native to the Lingnan region of China and developing dietary supplements from traditional herbal medicines aimed at various disease targets and pathogens, including cancer, human immunodeficiency virus (HIV), severe acute respiratory syndrome coronaviruses (SARS-CoV), hepatitis C virus (HCV), influenza viruses, Ebola/Marburg viruses, athlete’s foot fungi, tuberculosis, dental bacteria, and cancer chemoprevention. His efforts have resulted in the discovery of numerous lead compounds with novel structures and significant biological activities, some of which have been developed into marketed products.

     張宏杰博士現任香港浸會大學中醫藥學院教授，主要研究東南亞（包括嶺南）天然植物的藥用活性成分。他的工作包括天然小分子化合物的分離、純化、分析、結構解析、結構優化、合成、藥效評估和分子機制研究。張博士已發表論文190餘篇，獲得授權專利40多項。他對數千種植物提取物進行了生物活性評價，涵蓋抗癌、防癌、抗新冠病毒（SARS-CoV）、抗艾滋病病毒（HIV）、抗禽流感病毒、抗埃博拉病毒、抗牙菌菌膜、抗肺結核病和抗瘧疾等領域，並已發現多個結構新穎且具有高生物活性的先導分子化合物，其中一些產品已成功開發並上市。

Abbreviations

HKBU:            School of Chinese Medicine, Hong Kong Baptist University

KIB:                State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, The Chinese Academy of Sciences Kunming, Yunnan, China

UIC:                Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois Chicago, USA

I. ACADEMIC AND PROFESSIONAL QUALIFICATIONS

(i). Academic Qualifications

Postdoc. (04/99-09/03):      in Natural Products Chemistry, UIC

Ph.D. (09/91-09/94):             in Phytochemistry, KIB, Excellent Award of President Scholarship awarded by the president of the Chinese Academy of Sciences

M.S. (09/85-08/88):               in Phytochemistry, KIB

B.S. (09/81-07/85):                 in Organic Chemistry, Yunnan University, Kunming, China, 1^st Class Honor, and awarded with University Annual Scholarship from 1982-1985

(ii). Professional and Community Services

1. Member, American Chemical Society (2000-present)
2. Member, American Society of Pharmacognosy (2000-present)
3. Council Member, The Society of Hong Kong Scholars (2023-present)
4. Council Member, Modernized Chinese Medicine International Association Ltd. (MCMIA) (2024-present)
5. Vice Chairman, Chinese Medicine and Natural Medicine Toxicology Committee, Chinese Society of Toxicology (2024-present)
6. Senior Member, Botanical Society of China (BSC) (2024-present)

7. Senior Member of WFCMS (World Federation of Chinese Medicine Societies) Specialty Committee of Chinese Materia Medica (December 1 2025-present)

II. ACADEMIC AND PROFESSIONAL EXPERIENCE

07/2025-present              Chair Professor, School of Chinese Medicine, HKBU

07/2024-present              Cheung On Tak Endowed Professor in Chinese Medicine, HKBU

04/2024-present              Associate Dean of School of Chinese Medicine, HKBU

09/2019-06/2025              Professor, Director, Teaching and Reseach Division, HKBU

09/2019-present               Fellow, HKBU-UIC Joint Institute of Rsearch Studies (JIRS)

08/2012-present               Research Professor, HKBU’s Institute of Research and Continuing Education Shenzhen) (IRACE)

09/2019-06/2025              Director, Teaching and Research Division, HKBU

09/2018-06/2025              Professor, Teaching and Reseach Division, HKBU

12/2011-8/2018                Associate Professor, Teaching and Reseach Division, HKBU

01/2010-12/2014              Adjunct Professor, The Key Laboratory of Chemistry for NaturalProducts of Guizhou Province and Chinese Academy of Sciences

08/2007-11/2011               Research Associate Professor, UIC

10/2003-07/2007               Research Assistant Professor, UIC

11/1997-12/2002                Professor, KIB

04/1997-10/1997                Visiting Scholar, Xechem Inc., New Jersey, USA

05/1995-10/1997                Associate Professor, KIB

05/1991-04/1995                Assistant Professor, KIB

01/1993-01/1994                Visiting Scientist, Tokushima University, Japan

III. Journal Publications (>190)

1. Zhao CL,^# Du YX,^# Xia XX,^# Chen BS, Seng ZY, Liu KL, Lam CS, Zou J,* Zhang HJ.* Design, synthesis and biological evaluation of new ent-11α-hydroxy-15-oxo-kaur-16-en-19-oic-acid (5F) derivatives as potential antitumor agents. Bioorganic & Medicinal Chemistry 2026; 135 (2026), Article 118568.

   https://doi.org/10.1016/j.bmc.2026.118568

2. Chen MT,^# Chen BS,^# He QY, Xiao SL, Li BT, Ye Y, Zhang HJ, Wong HLX, Ji Y,* Su T,* Kwan HY.* 15,16-Dihydrotanshinone I, a novel β-catenintargeting inhibitor that inhibits its nuclear translocation and reduces downstream CD36 expression in cancer. Journal of Translational Medicine 2025; 23 (1), 1335.

   https://doi.org/10.1186/s12967-025-07317-1

3. Zhao CL, ^# Yang YX, ^# Mamun AA,^# Wang L, Li GJ, Ye JH, Zhang JJ, Pan LT, He K,* Zou J,* Zhang HJ.* Cytotoxic and anticoagulative diterpenoid glycosides from Pteris decrescens. Phytochemistry 2025; 240 (2025), Article 114643.

   https://doi.org/10.1016/j.phytochem.2025.114643

4. Chen GQ,# Li WF,# Lam KH, Hu MY, Wu Q, Xu XY, Huang YZ, Tang F, Cui GH, Cui P, Zuo JP, Liu LN, Qian J,* Zhang HJ,* Li YP.* A nitrogen-containing diphyllin derivative C156-P1 exhibited broad-spectrum antiviral activity against Flaviviridae viruses by preventing endosomal acidification. Antimicrobial Agents and Chemotherapy 2025; 69 (11), e0052725.

   https://doi.org/10.1128/aac.00527-25

5. Dong MH,# Zhao CL,# Tsang NY, Zhou L, Chen RS, Xu CY, Ye JH, Pan LT, Zou J,* Zhang JJ,* Zhang HJ.* Three new C20-norditerpenoids (abietamethinols H–J) and a new sesquiterpenoid (guamethinol A) from Isodon amethystoides and their bioactivity. Journal of Molecular Structure 2025; 1348 (Part 1), Article 143416.

   https://doi.org/10.1016/j.molstruc.2025.143416
6. Zhou L,^#Zhao CL,^# Xu CY, Dong MH, Ye JH, Zhang JJ, Pan LT, Zou J,* Zhang HJ.* Abietane diterpenoids from Isodon amethystoides and their biological activities. Phytochemistry 2024; 225 (2024), Article 114171. https://doi.org/10.1016/j.phytochem.2024.114171
7. Zhao CL,^#Zhang CY,^# Yang XM,^# Lam KH, Xia YX, Du YX, Pan LT, Zhang HJ*.Design and synthesis of oridonin derivatives as cytotoxic agents. Natural Product Research 2023; 1-9. https://doi.org/10.1080/14786419.2023.2275287
8. Peng Y, Yang XW, Huang RM, Ren B, Chen B, Liu YH, Zhang HJ.* Diversified chemical structures and bioactivities of the chemical constituents found in the brown algae family Sargassaceae. Marine Drugs2024; 22 (2), Article 59 (30 pages). https://doi.org/10.3390/md22020059
9. Lam CS, Xia YX, Chen BS, Du YX, Liu KL, Zhang HJ.* Dihydro-resveratrol attenuates oxidative stress, adipogenesis and insulin resistance in in vitro models and high-fat diet-induced mouse model via AMPK activation. Nutrients2023; 15 (13), Article 3006 (16 pages). https://doi.org/10.3390/nu15133006
10. Xie WJ,^#Xu XY,^# Xia YX,^# Lam CS, Chen T, Zhi YS, Lee KM, Song S, Deyrup ST,* He ZD,* Zhang HJ.* Identification and bioactivity evaluation of miliusanes from Miliusa sinensis. Bioorganic Chemistry 2023, 140 (2023), Article number: 106797 (13 pages). https://doi.org/10.1016/j.bioorg.2023.106797
11. Zhao LH,^#Xie WJ,^# Du YX,^# Xia YX, Liu KL, Ku CF, Ou ZH, Wang MZ,* Zhang HJ.* Isolation and anticancer progression evaluation of the chemical constituents from Bridelia balansae Molecules 2023; 28 (16), Article 6165 (13 pages). https://doi.org/10.3390/molecules28166165
12. Zou J,^#Ye JH,^# Zhao CL, Zhang JJ, Liu YH, Pan LT, He K,* Zhang HJ.* Guidongnins I-J, two new 6,7-seco-7,20-olide-ent-kaurene diterpenes with unusual structures from Isodon rubescens. International Journal of Molecular Sciences 2023; 24, Article 13451 (8 pages). https://doi.org/10.3390/ijms241713451
13. Li JL,* Jiang JY, Gu SS, Zhang L, Sun Y, Wang XH, Li DY, Chen ZY, Jiang SS, Zhu WZ, HW, Zhang HJ.* Identification of lignans as ATP citrate lyase (ACLY) inhibitors from the roots of Pouzolzia zeylanica. Natural Product Research2023; 38 (10), 1719-1726. https://doi.org/10.1080/14786419.2023.2219816
14. Hu MY,^#Li WF,^# Wu TT, Yang Y, Chen GQ, Chen TL, Liu YC, Mei YQ, Wu D, Wei YC, Luo TR, Zhang HJ,* Li YP*. Identification of an arylnaphthalene lignan derivative as an inhibitor against dengue virus serotypes 1 to 4 (DENV-1 to -4) using a newly developed DENV-3 infectious clone and replicon. Microbiology Spectrum 2023; 11 (4), e00423-23. https://doi.org/ 10.1128/spectrum.00423-23
15. Ye JH,^#Luo GY,^# Zhao CL,^# Liang ZM,^# Wei JH, Liu YH, He K, Pan LT, Zhang JJ, Zou J,* Zhang HJ.* Flavidanolides A and B from Isodon flavidus. Chinese Chemical Letters 2023; 34 (9), Article108621 (5 pages). https://doi.org/10.1016/j.cclet.2023.108621
16. Durairajan SSK,* Singh AK, Saravanan UB, Namachivayam M, Radhakrishnan M, Huang JD, Dhodapkar R,* Zhang HJ.* Gastrointestinal manifestations of SARS-CoV-2: transmission, pathogenesis, immunomodulation, microflora dysbiosis, and clinical implications. Viruses2023; 15 (6), Article 1231 (24 pages). https://doi.org/10.3390/v15061231
17. Du YX,^#Mamun AA,^# Lyu AP*, Zhang HJ.* Natural compounds targeting the autophagy pathway in the treatment of colorectal cancer. International Journal of Molecular Sciences 2023; 24 (8), Article 7310 (27 pages). https://doi.org/10.3390/ijms24087310
18. Sreenivasmurthy SG,^#Iyaswamy A,^# Krishnamoorthi S,^# Reddi RN, Kammala AK, Vasudevan K, Senapati S, Zhu Z, Su CF, Liu J, Guan XJ, Chua KK, Cheung KH, Chen CB, Zhang HJ, Zhang Y, Song JX, Durairajan SSK*, Li M.* Bromo-protopine, a novel protopine derivative, alleviates tau pathology by activating chaperone-mediated autophagy for Alzheimer's disease therapy. Frontiers in Molecular Biosciences 2022; 9, 1030534. https://doi.org/10.3389/fmolb.2022.1030534
19. Fan N, Zhang XY, Zhao W, Zhao J, Luo D, Sun YL, Li D, Chenliang Zhao CL, Wang Y, Zhang HJ, Rong JH.* Covalent inhibition of pyruvate kinase M2 reprograms metabolic and inflammatory pathways in hepatic macrophages against non-alcoholic fatty liver disease. International Journal of Biological Sciences2022; 18 (14), 5260-5275. https://doi.org/10.7150/ijbs.73890
20. Zhao CL,^#Zhou L,^# Xie WJ,^# Zhao LH, Zhang CY, He K, Ye JH, Zhang JJ, Pan LT, Zou J,* Zhang HJ.* Bioactive isopimarane and 3,4‑seco isopimarane diterpenoids from Isodon amethystoides. BMC Chemistry 2022; 16, Article 96 (11 pages). https://doi.org/10.1186/s13065-022-00880-4
21. Yu X,^#Song X,^# Zhang Y,^# Yang YM,^# Ye JH, Liu YH, Pan LT,* Zhang HJ.* Design, synthesis and biological evaluation of lophanic acid derivatives as antifungal and antibacterial agents. Molecules 2022; 27 (20), Article 6836 (15 pages). https://doi.org/10.3390/molecules27206836
22. Mamun AA, Uddin MS, Perveen A, Jha NK, Alghamdi BS, Jeandet P, Zhang HJ, Ashraf GM.* Inflammation-targeted nanomedicine against brain cancer: from design strategies to future developments. Seminars in Cancer Biology 2022; 86 (Part 2), 101-116. https://doi.org/10.1016/j.semcancer.2022.08.007
23. Zhao Y,^#Tsang NY,^# Xu XY, Zhao CL, Ku CF, Li WF, Zhu Y, Liu KL, Rong LJ, Zhang HJ.* Axial chirality and antiviral activity evaluation of arylnaphthalene lignan glycosides from Justicia procumbens. Asian Journal of Organic Chemistry 2022; 11 (8), e202200267. https://doi.org/10.1002/ajoc.202200267
24. Li WF,^#Liang ZM, ^# Zhao CL, Tsang NY, Li JX, Liu YH, He K,  Pan LT,  Rong LJ, Zhou J,* Zhang HJ.* 3,4-Seco-isopimarane diterpenes from the twigs and leaves of Isodon flavidus. Molecules 2022; 27 (10), Article 3098 (10 pages). https://doi.org/10.3390/molecules27103098
25. Tsang NY,^#Li WF,^# Varhegyi E,^# Rong LJ,* Zhang HJ.* Ebola entry inhibitors discovered from Maesa perlarius. International Journal of Molecular Sciences 2022; 23 (5), Article 2620 (20 pages). https://doi.org/10.3390/ijms23052620
26. Deng R,^#Zou J,^# Zhao CL,^# Yang YM,^# Ku CF, Zhu Y, Liang ZM, Ye JH, Pan LT,* Zhang HJ.* Bioactive icetexane and abietane diterpenes from Isodon phyllopodus. Natural Product Research 2023; 37 (1), 68-76. https://doi.org/10.1080/14786419.2021.1950716
27. Mamun AA, Sufian MA, Uddin MS, Sumsuzzman DM, Jeandet P, MS, Zhang HJ, Kong AN, Sarwar MS.* Exploring the role of senescence inducers and senotherapeutics as targets for anticancer natural products. European Journal of Pharmacology2022; 928, 174991. https://doi.org/ 10.1016/j.ejphar.2022.174991
28. Zhu Z, Liu LF, Su CF, Liu J, Tong BCK, Iyaswamy A, Krishnamoorthi S, Sreenivasmurthy SG, Guan XJ, Kan YX, Xie WJ, Zhao CL, Cheung KH, Lu JH, Tan JQ, Zhang HJ, Song JX,* Li M.* Corynoxine B derivative CB6 prevents Parkinsonian toxicity in mice by inducing PIK3C3 complex-dependent autophagy. Acta Pharmacologica Sinica2022; 43 (10), 2511-2526. https://doi.org/10.1038/s41401-022-00871-0
29. Guguloth SK, Lakshmi AR, Rajendran R, Rajaram K, Chinnasamy T, Huang JD, Zhang HJ, Senapati S, Durairajan SSD.* A mechanistic review on plant-derived natural inhibitors of human coronaviruses with emphasis on SARS-COV-1 and SARS-COV-2. Current Drug Targets2022; 23 (8), 818-835. https://doi.org/ 10.2174/1389450122666211005115313
30. Chen SC,^#Tsang NY,^# Jiang HW,^# Zhang HJ, Ge X, Wu YN, Shen Y, Wenxia WX, Li JL.* Cytotoxic tigliane diterpenoids from Euphorbia neorubella. Natural Product Research 2021; 36 (11), 2753-2757. https://doi.org/10.1080/14786419.2021.1924712
31. YX, Zhao CL, Ye JH, Zhang JJ, Pan LT,* Zhang HJ.* Rubesanolides F and G: two novel lactone-type norditerpenoids from Isodon rubescens. Molecules2021; 26 (13), Article 3865 (9 pages). https://doi.org/10.3390/molecules26133865
32. Xu XY,^#Wong DY,^# Li YP, Deyrup ST,* Zhang HJ.* Plant-derived lignans as potential antiviral agents: a systematic review. Phytochemistry Reviews 2022; 21 (1), 239-289. https://doi.org/10.1007/s11101-021-09758-0
33. Zhang JN,^#Xia YX,^# Zhang HJ.* Natural cyclopeptides as anticancer agents in the last 20 years. International Journal of Molecular Sciences 2021; 22 (8), Article 3973 (58 pages). https://doi.org/10.3390/ijms22083973
34. Zhao Y, Ku CF, Xu XY, Tsang NY, Zhu Y, Zhao CL, Liu KL, Li CC, Rong LJ, Zhang HJ.* Stable axially chiral isomers of arylnaphthalene lignan glycosides with antiviral potential discovered from Justicia procumbens. The Journal of Organic Chemistry2021; 86 (8), 5568-5583. https://doi.org/10.1021/acs.joc.1c00068
35. Aziz MA,^#Sarwar MS,^#,* Akter T, Uddin MS, Song X, Zhu Y, Islam MS, Zhang HJ.* Polyphenolic molecules targeting STAT3 pathway for the treatment of cancer. Life Sciences 2021; 268, Article 118999 (17 pages). https://doi.org/10.1016/j.lfs.2020.118999
36. Wong-Deyrup SW,^# Song X,^# Ng TW, Liu XB, Zeng JG, Qing ZX, Deyrup ST, He ZD,* Zhang HJ.* Plant-derived isoquinoline alkaloids that target ergosterol biosynthesis discovered by using a novel antifungal screening tool. Biomedicine & Pharmacotherapy 2021; 137, Article 111348 (12 pages). https://doi.org/10.1016/j.biopha.2021.111348

IV. Others

A. Journal editor

1. Associate Editor, Pharmaceutical Biology, (2017-2025).
2. Guest Editor, The Journal Current Medicinal Chemistry, for special issue of “Advances in the development of potential anti-invasive drugs and strategies focused on overcoming drug resistance”.
3. Guest Editor, The Journal Current Organic Chemistry, for special issue of “Anti-infective drug discovery based on diversified plant natural compounds”.
4. Guest Editor, The Journal Frontiers in Pharmacology, for special issue of “Can Natural Products Reduce the Side Effects of Cancer Therapies?” (2018).
5. Guest Editor, The Journal International Journal of Molecular Sciences, for special issue of “Plant Natural Products for Human Health” (2019).
6. Guest Editor, The Journal International Journal of Molecular Sciences, for special issue of “Plant Natural Products for Human Health” (2022).
7. Guest Editor, The Journal International Journal of Molecular Sciences, for special issue of “Plant Natural Products for Human Health” (2025).

B. Honours, awards and prizes

1. Patents: >40 patents granted in China, USA, European countries, Japan, Singapore, etc.

2. 2026: Knowledge Transfer Award, Hong Kong Baptist University.

3. 2025: School Outstanding Performance Award in Research Supervision, Hong Kong Baptist University.

4. 2020-2024: World's top 2% Scientists' List Stanford University: 2020, 2021, 2022, 2023, 2024.

5. 2026: Silver Medal, 2nd Yangtze River Economic Belt High-Value Patent Translational Competition for “Skin protection composition based on Dendrobium constituents”.

6. 2025: Silver Medal, 2025 Silicon Valley International Invention Festival (SVIIF) for the invention of “Development of Justicia Chinese Medicinal Plants as Antiviral Veterinary Products”.

7. 2024: Silver Medal, the 7th China (Shanghai) International Exhibition of Inventions for the invention of “Skin-protection composition containing Dendrobium-based stilbenoid ingredients”.

8. 2024: Bronze Medal, the 49th Geneva International Exhibition of Inventions 2024 for the invention of “Health Products for Anti-fibrosis”.

9. 2022: Silver Medal, the 47th Geneva International Exhibition of Inventions 2022 for the invention of “Skin Whitening and Anti-ageing Skin Care Product”.

10. 2021: School Outstanding Performance Award in Teaching, Hong Kong Baptist University.

11. 2020: School Outstanding Performance Award in Research Supervision, Hong Kong Baptist University.

12. 2017: President’s Award for Outstanding Performance of Scholarly Work, Hong Kong Baptist University.

13. 2002: First-Grade Award of Natural Science of Yunnan Province, China in the project of “Study of Diterpenoids from IsodonPlants and their Biological Activity”.

14. 1996: Young and Middle-aged Leader Award in Science & Technology Realms of Yunnan Province, China.

15. 1992: Second-Grade Award of the Chinese Academy of Sciences in the project of “Research on Bioactive Diterpenoids in IsodonPlants of Labiatae”.