Yuanyuan YU

2024

Intracellular sclerostin plays a vital role in tumor progression and metastasis in triple-negative breast cancer

Sun, M., Qiao, S., Luo, H., Yang, X., Yang, L., Zhang, H., Chen, Z., Wang, L., Tao, X., Yu, Y., Ma, Y., Yuan, F., Ma, D., Chen, Q., Lu, A., Zhang, B. T., Zhang, G. & Li, F., 1 Feb 2024, In: Cancer Research. 84, 3, Supplement 1, B044.

Research output: Contribution to journal › Conference article › peer-review

Pan-genome analysis of Streptococcus suis serotype 2 highlights genes associated with virulence and antibiotic resistance

Zhou, Y., Tu, T., Yao, X., Luo, Y., Yang, Z., Ren, M., Zhang, G., Yu, Y., Lu, A. & Wang, Y., 21 Feb 2024, In: Frontiers in Microbiology. 15, 19 p., 1362316.

Research output: Contribution to journal › Journal article › peer-review

Open Access

1 Citation (Scopus)

Sclerostin inhibition in rare bone diseases: Molecular understanding and therapeutic perspectives

Tao, X., Wang, L., Yang, X., Jiang, H., Zhang, N., Zhang, H., Li, D., Li, X., Zhang, Y., Wang, S., Zhong, C., Yu, S., Ren, M., Sun, M., Li, N., Chen, T., Ma, Y., Li, F., Liu, J., Yu, Y., & 3 othersYue, H., Zhang, Z. & Zhang, G., Jul 2024, In: Journal of Orthopaedic Translation. 47, p. 39-49 11 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

1 Citation (Scopus)

Unique quinoline orientations shape the modified aptamer to sclerostin for enhanced binding affinity and bone anabolic potential

Gubu, A., Ma, Y., Yu, S., Zhang, H., Chen, Z., Ni, S., Abdullah, R., Xiao, H., Zhang, Y., Dai, H., Luo, H., Yu, Y., Wang, L., Jiang, H., Zhang, N., Tian, Y., Li, H., Lu, A., Zhang, B. & Zhang, G., 12 Mar 2024, In: Molecular Therapy Nucleic Acids. 35, 1, 14 p., 102146.

Research output: Contribution to journal › Journal article › peer-review

Open Access

1 Citation (Scopus)

2023

A bimolecular modification strategy for developing long-lasting bone anabolic aptamer

Zhang, H., Yu, S., Ni, S., Gubu, A., Ma, Y., Zhang, Y., Li, H., Wang, Y., Wang, L., Zhang, Z., Yu, Y., Lyu, A., Zhang, B. & Zhang, G., 12 Dec 2023, In: Molecular Therapy - Nucleic Acids. 34, 18 p., 102073.

Research output: Contribution to journal › Journal article › peer-review

Open Access

1 Citation (Scopus)

Development of a Real-Time TaqMan RT-PCR Assay for the Detection of NADC34-like Porcine Reproductive and Respiratory Syndrome Virus

Tu, T., Pang, M., Jiang, D., Zhou, Y., Wu, X., Yao, X., Luo, Y., Yang, Z., Ren, M., Lu, A., Zhang, G., Yu, Y. & Wang, Y., 6 Apr 2023, In: Veterinary Sciences. 10, 4, 11 p., 279.

Research output: Contribution to journal › Journal article › peer-review

Open Access

2 Citations (Scopus)

Editorial: Aptamer-based structural biology, computational modelling, translational research and drug discovery, Volume II

Ma, Y., Yu, Y., Zhang, B., Lu, A. & Zhang, G., 15 May 2023, In: Frontiers in Cell and Developmental Biology. 11, 2 p., 1195372.

Research output: Contribution to journal › Editorial

Open Access

Exploring the Potential of Aptamers in Targeting Neuroinflammation and Neurodegenerative Disorders: Opportunities and Challenges

Kong, A. H. Y., Wu, A. J., Ho, O. K. Y., Leung, M. M. K., Huang, A. S., Yu, Y., Zhang, G., Lyu, A., Li, M. & Cheung, K. H., 2 Jul 2023, In: International Journal of Molecular Sciences. 24, 14, 33 p., 11780.

Research output: Contribution to journal › Journal article › peer-review

Open Access

3 Citations (Scopus)

Macrophagic Sclerostin Loop2-ApoER2 Interaction Required by Sclerostin for Suppressing Inflammatory Responses (Abstract)

Wang, L., Zhang, N., Liu, J., Yang, X., Yu, Y., Li, D., Jiang, H., Sun, M., Li, N., Ma, D., Huang, Y., Lu, A., Zhang, B. & Zhang, G., May 2023, In: Metabolism: Clinical and Experimental. 142, Supplement, 1 p., 155427.

Research output: Contribution to journal › Conference article › peer-review

Pan-genome wide association study of Glaesserella parasuis highlights genes associated with virulence and biofilm formation

Zhou, Y., Jiang, D., Yao, X., Luo, Y., Yang, Z., Ren, M., Zhang, G., Yu, Y., Lu, A. & Wang, Y., 17 Apr 2023, In: Frontiers in Microbiology. 14, 22 p., 1160433.

Research output: Contribution to journal › Journal article › peer-review

Open Access

1 Citation (Scopus)

The application of Aptamer in biomarker discovery

Li, Y., Tam, W. W., Yu, Y., Zhuo, Z., Xue, Z., Tsang, C., Qiao, X., Wang, X., Wang, W., Li, Y., Tu, Y. & Gao, Y., 19 Jul 2023, In: Biomarker Research. 11, 17 p., 70.

Research output: Contribution to journal › Review article › peer-review

Open Access

16 Citations (Scopus)

The Role of Sclerostin in Lipid and Glucose Metabolism Disorders

Jiang, H., Li, D., Han, Y., Li, N., Tao, X., Liu, J., Zhang, Z., Yu, Y., Wang, L., Yu, S., Zhang, N., Xiao, H., Yang, X., Zhang, Y., Zhang, G. & Zhang, B-T., Sept 2023, In: Biochemical Pharmacology. 215, 115694.

Research output: Contribution to journal › Review article › peer-review

2 Citations (Scopus)

2022

Drug Discovery of DKK1 Inhibitors

Jiang, H., Zhang, Z., Yu, Y., Chu, H. Y., Yu, S., Yao, S., Zhang, G. & Zhang, B. T., 9 Mar 2022, In: Frontiers in Pharmacology. 13, 847387.

Research output: Contribution to journal › Review article › peer-review

Open Access

33 Citations (Scopus)

Drug discovery of sclerostin inhibitors

Yu, S., Li, D., Zhang, N., Ni, S., Sun, M., Wang, L., Xiao, H., Liu, D., Liu, J., Yu, Y., Zhang, Z., Yeung, S. T. Y., Zhang, S., Lu, A., Zhang, Z., Zhang, B. & Zhang, G., May 2022, In: Acta Pharmaceutica Sinica B. 12, 5, p. 2150-2170 21 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

23 Citations (Scopus)

Selection and characterization of DNA aptamers inhibiting a druggable target of osteoarthritis, ADAMTS-5

Yu, Y., Liu, M., Choi, V. N. T., Cheung, Y. W. & Tanner, J. A., Oct 2022, In: Biochimie. 201, p. 168-176 9 p.

Research output: Contribution to journal › Journal article › peer-review

3 Citations (Scopus)

Targeting loop3 of sclerostin preserves its cardiovascular protective action and promotes bone formation

Yu, Y., Wang, L., Ni, S., Li, D., Liu, J., Chu, H. Y., Zhang, N., Sun, M., Li, N., Ren, Q., Zhuo, Z., Zhong, C., Xie, D., Li, Y., Zhang, Z. K., Zhang, H., Li, M., Zhang, Z., Chen, L., Pan, X., & 5 othersXia, W., Zhang, S., Lu, A., Zhang, B. T. & Zhang, G., 22 Jul 2022, In: Nature Communications. 13, 16 p., 4241.

Research output: Contribution to journal › Journal article › peer-review

Open Access

116 Citations (Scopus)

Therapeutic aptamer targeting sclerostin loop3 for promoting bone formation without increasing cardiovascular risk in osteogenesis imperfecta mice

Wang, L., Yu, Y., Ni, S., Li, D., Liu, J., Xie, D., Chu, H. Y., Ren, Q., Zhong, C., Zhang, N., Li, N., Sun, M., Zhang, Z. K., Zhuo, Z., Zhang, H., Zhang, S., Li, M., Xia, W., Zhang, Z., Chen, L., & 5 othersShang, P., Pan, X., Lu, A., Zhang, B. T. & Zhang, G., 18 Jul 2022, In: Theranostics. 12, 13, p. 5645-5674 30 p.

Research output: Contribution to journal › Journal article › peer-review

Open Access

55 Citations (Scopus)

2021

Artificial Intelligence in Aptamer–Target Binding Prediction

Chen, Z., Hu, L., Zhang, B-T., Lu, A., Wang, Y., Yu, Y. & Zhang, G., 1 Apr 2021, In: International Journal of Molecular Sciences. 22, 7, 3605.

Research output: Contribution to journal › Review article › peer-review

Open Access

59 Citations (Scopus)

Current Pharmacological Strategies for Duchenne Muscular Dystrophy

Yao, S., Chen, Z., Yu, Y., Zhang, N., Jiang, H., Zhang, G., Zhang, Z. & Zhang, B., 19 Aug 2021, In: Frontiers in Cell and Developmental Biology. 9, 689533.

Research output: Contribution to journal › Review article › peer-review

Open Access

33 Citations (Scopus)

Dickkopf-1: A Promising Target for Cancer Immunotherapy

Chu, H. Y., Chen, Z., Wang, L., Zhang, Z. K., Tan, X., Liu, S., Zhang, B. T., Lu, A., Yu, Y. & Zhang, G., 20 May 2021, In: Frontiers in Immunology. 12, 14 p., 658097.

Research output: Contribution to journal › Review article › peer-review

Open Access

41 Citations (Scopus)

Exosomal transfer of osteoclast-derived miRNAs to chondrocytes contributes to osteoarthritis progression

Liu, J., Wu, X., Lu, J., Huang, G., Dang, L., Zhang, H., Zhong, C., Zhang, Z., Li, D., Li, F., Liang, C., Yu, Y., Zhang, B. T., Chen, L., Lu, A. & Zhang, G., 15 Apr 2021, In: Nature Aging. 1, 4, p. 368–384 17 p.

Research output: Contribution to journal › Journal article › peer-review

31 Citations (Scopus)

Neolignans and Diarylheptanoids with Anti-Inflammatory Activity from the Rhizomes of Alpinia zerumbet

Zhang, Y., Yu, Y. Y., Peng, F., Duan, W. T., Wu, C. H., Li, H. T., Zhang, X. F. & Shi, Y. S., 18 Aug 2021, In: Journal of Agricultural and Food Chemistry. 69, 32, p. 9229–9237 9 p.

Research output: Contribution to journal › Journal article › peer-review

11 Citations (Scopus)

Recent Progress in Aptamer Discoveries and Modifications for Therapeutic Applications

Ni, S., Zhuo, Z., Pan, Y., Yu, Y., Li, F., Liu, J., Wang, L., Wu, X., Li, D., Wan, Y., Zhang, L., Yang, Z., Zhang, B-T., Lu, A. & Zhang, G., 3 Mar 2021, In: ACS Applied Materials and Interfaces. 13, 8, p. 9500-9519 20 p.

Research output: Contribution to journal › Journal article › peer-review

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326 Citations (Scopus)

368 Downloads (Pure)

Structural Biology for the Molecular Insight between Aptamers and Target Proteins

Zhang, N., Chen, Z., Liu, D., Jiang, H., Zhang, Z-K., Lu, A., Zhang, B-T., Yu, Y. & Zhang, G., 15 Apr 2021, In: International Journal of Molecular Sciences. 22, 8, 27 p., 4093.

Research output: Contribution to journal › Review article › peer-review

Open Access

39 Citations (Scopus)

The Application of Microfluidic Technologies in Aptamer Selection

Liu, Y., Wang, N., Chan, C-W., Lu, A., Yu, Y., Zhang, G. & Ren, K., 17 Sept 2021, In: Frontiers in Cell and Developmental Biology. 9, 11 p., 730035.

Research output: Contribution to journal › Review article › peer-review

Open Access

24 Citations (Scopus)

The Roles of Sclerostin in Immune System and the Applications of Aptamers in Immune-Related Research

Sun, M., Chen, Z., Wu, X., Yu, Y., Wang, L., Lu, A., Zhang, G. & Li, F., 25 Feb 2021, In: Frontiers in Immunology. 12, 10 p., 602330.

Research output: Contribution to journal › Journal article › peer-review

Open Access

6 Citations (Scopus)

2020

A Loop-Based and AGO-Incorporated Virtual Screening Model Targeting AGO-Mediated miRNA–mRNA Interactions for Drug Discovery to Rescue Bone Phenotype in Genetically Modified Mice

Zhuo, Z., Wan, Y., Guan, D., Ni, S., Wang, L., Zhang, Z., Liu, J., Liang, C., Yu, Y., Lu, A., Zhang, G. & Zhang, B-T., Jul 2020, In: Advanced Science. 7, 13, 22 p., 1903451.

Research output: Contribution to journal › Journal article › peer-review

Open Access

114 Citations (Scopus)

A PD-L1 aptamer selected by loss-gain cell-SELEX conjugated with paclitaxel for treating triple-negative breast cancer

Wu, X., Li, F., Li, Y., Yu, Y., Liang, C., Zhang, B., Zhao, C., Lu, A. & Zhang, G., 23 Jun 2020, In: Medical Science Monitor. 26, 10 p., e925583.

Research output: Contribution to journal › Journal article › peer-review

Open Access

26 Citations (Scopus)

Connective Tissue Growth Factor: From Molecular Understandings to Drug Discovery

Chen, Z., Zhang, N., Chu, H. Y., Yu, Y., Zhang, Z-K., Zhang, G. & Zhang, B-T., 29 Oct 2020, In: Frontiers in Cell and Developmental Biology. 8, 593269.

Research output: Contribution to journal › Review article › peer-review

Open Access

85 Citations (Scopus)

Disorders of Calcium and Phosphorus Metabolism and the Proteomics/Metabolomics-Based Research

Sun, M., Wu, X., Yu, Y., Wang, L., Xie, D., Zhang, Z., Chen, L., Lu, A., Zhang, G. & Li, F., 10 Sept 2020, In: Frontiers in Cell and Developmental Biology. 8, 13 p., 576110.

Research output: Contribution to journal › Journal article › peer-review

Open Access

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38 Citations (Scopus)

61 Downloads (Pure)

Pros and Cons of Denosumab Treatment for Osteoporosis and Implication for RANKL Aptamer Therapy

Zhang, N., Zhang, Z-K., Yu, Y., Zhuo, Z., Zhang, G. & Zhang, B-T., 14 May 2020, In: Frontiers in Cell and Developmental Biology. 8, 9 p., 325.

Research output: Contribution to journal › Review article › peer-review

Open Access

44 Citations (Scopus)

Sclerostin loop3: a potential target for developing a next generation sclerostin inhibitor for bone anabolic therapy with low cardiovascular concern (Abstract)

Yu, Y., Wang, L., Ni, S., Zhuo, Z., Chu, H. Y., Zhang, N., Li, D., Liu, J., Lyu, A., Zhang, B. T. & Zhang, G., Nov 2020, In: Journal of Bone and Mineral Research. 35, S1, p. 252 1 p., P-657.

Research output: Contribution to journal › Conference article › peer-review

Open Access

Synthesis and in vitro evaluation of a bispecific aptamer targeting both Sclerostin and Dickkopf-1 (Abstract)

Zhuo, Z., Ni, S., Zhang, Z., Zhang, N., Yu, Y., Lu, A., Zhang, G. & Zhang, B. T., Nov 2020, In: Journal of Bone and Mineral Research. 35, SI, p. 238 1 p., P-615.

Research output: Contribution to journal › Conference article › peer-review

Open Access

1 Citation (Scopus)

2019

A potential next generation sclerostin inhibitor specifically targets sclerostin Loop3 for bone anabolic therapy with low cardiovascular risk in osteogenesis imperfecta mice

Zhang, G. & Yu, Y., 10 Oct 2019.

Research output: Contribution to conference › Conference paper › peer-review

A potential next generation sclerostin inhibitor specifically targets sclerostin monomer for bone anabolic therapy with low ardiovascular risk in osteogenesis imperfecta mice (Abstract)

Ren, Q., Xie, D., Yu, Y., Tang, Y., Ni, S., Lu, J., Lu, A., Zhang, G., Chan, S. Y. & Zhang, B. T., Dec 2019, In: Journal of Bone and Mineral Research. 34, S1, p. 47-48 2 p.

Research output: Contribution to journal › Conference article › peer-review

A Potential Next Generation Sclerostin Inhibitor Specifically Targets Sclerostin Monomer for Bone Anabolic Therapy with Low Cardiovascular Risk to Reverse Established Osteoporosis in Ovariectomized Rats (Abstract)

Yu, Y., Ren, Q., Ni, S., Liu, J., Zhong, C., Lu, J., Tang, Y., Li, D., Xie, D., Dai, R., Zhang, H., Dang, L., Lyu, A., Zhang, G., Zhuo, Z., Zhang, Z-K., Zhang, B. T., Wang, L., Li, Y., Wong, K. K., & 1 othersZhai, J., Dec 2019, In: Journal of Bone and Mineral Research. 34, S1, p. 264 1 p.

Research output: Contribution to journal › Conference article › peer-review

2017

A water-soluble nucleolin aptamer-paclitaxel conjugate for tumor-specific targeting in ovarian cancer

Li, F., Lu, J., Liu, J., Liang, C., Wang, M., Wang, L., Li, D., Yao, H., Zhang, Q., Wen, J., Zhang, Z. K., Li, J., Lv, Q., He, X., Guo, B., Guan, D., Yu, Y., Dang, L., Wu, X., Li, Y., & 6 othersChen, G., Jiang, F., Sun, S., Zhang, B. T., Lyu, A. & Zhang, G., 9 Nov 2017, In: Nature Communications. 8, 1, 14 p., 1390.

Research output: Contribution to journal › Journal article › peer-review

Open Access