Projects per year
Personal profile
Chinese Name
于媛媛
Research Interests
1) Optimization of aptamer selection methodology;
2) Aptamer-based translational medicine and drug discovery;
3) Aptamer structural biology
Biography
Dr. Yuanyuan Yu is a tenure track Assistant Professor in the School of Chinese Medicine. She earned her PhD in Biochemistry from Faculty of Medicine at the University of Hong Kong in 2015. After graduation, she joined the School of Chinese Medicine at Hong Kong Baptist University as a postdoctoral research fellow from 2015 to 2019. She was promoted to Research Assistant Professor in 2019 and Assistant Professor in 2022. Dr. Yu has undertaken multiple external grants in the capacity of PI (such as GRF-RGC and NSFC). Dr. Yu has focused on developing therapeutic aptamers for various diseases. Her research mainly focuses on aptamer-based drug discovery, including understanding disease mechanisms, identifying targets and discovering drug for diseases, particularly rare and geriatric diseasesthat lack specific treatments.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
PhD, The University of Hong Kong
1 Sept 2010 → 28 Feb 2015
Award Date: 21 Nov 2015
External positions
Guangdong‐Hong Kong Macao Greater Bay Area International Research Platform for Aptamer‐Based Translational Medicine and Drug Discovery
1 Jan 2017 → …
Keywords
- QH301 Biology
- Biochemistry
- Molecular Biology
- RM Therapeutics. Pharmacology
- Drug Discovery
- Aptamer
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Dive into the research topics where Yuanyuan YU is active. Topic labels come from the works of this scholar.
- 1 Similar Scholars
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Equipment Matching Fund - High-performance Slide Scanner
LIU, J., LI, F., YU, Y., XU, J., FU, X., WONG, H. L. X., KWAN, H. Y. & CHONG, W. P.
26/03/24 → 25/03/26
Project: Research project
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The role of the interactions between N domain and Linker 2 of DKK1 in modulating the immunosuppressive tumor microenvironment mediated by DKK1 C domain
YU, Y. & Li, P.
1/01/23 → 30/06/25
Project: Research project
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Targeting sclerostin loop3 to promote bone formation with low cardiovascular risk in animal models
1/01/21 → 31/12/23
Project: Research project
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Intracellular sclerostin plays a vital role in tumor progression and metastasis in triple-negative breast cancer
Sun, M., Qiao, S., Luo, H., Yang, X., Yang, L., Zhang, H., Chen, Z., Wang, L., Tao, X., Yu, Y., Ma, Y., Yuan, F., Ma, D., Chen, Q., Lu, A., Zhang, B. T., Zhang, G. & Li, F., 1 Feb 2024, In: Cancer Research. 84, 3, Supplement 1, B044.Research output: Contribution to journal › Conference article › peer-review
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Pan-genome analysis of Streptococcus suis serotype 2 highlights genes associated with virulence and antibiotic resistance
Zhou, Y., Tu, T., Yao, X., Luo, Y., Yang, Z., Ren, M., Zhang, G., Yu, Y., Lu, A. & Wang, Y., 21 Feb 2024, In: Frontiers in Microbiology. 15, 19 p., 1362316.Research output: Contribution to journal › Journal article › peer-review
Open Access1 Citation (Scopus) -
Sclerostin inhibition in rare bone diseases: Molecular understanding and therapeutic perspectives
Tao, X., Wang, L., Yang, X., Jiang, H., Zhang, N., Zhang, H., Li, D., Li, X., Zhang, Y., Wang, S., Zhong, C., Yu, S., Ren, M., Sun, M., Li, N., Chen, T., Ma, Y., Li, F., Liu, J., Yu, Y., & 3 others, Jul 2024, In: Journal of Orthopaedic Translation. 47, p. 39-49 11 p.Research output: Contribution to journal › Review article › peer-review
Open Access1 Citation (Scopus) -
Unique quinoline orientations shape the modified aptamer to sclerostin for enhanced binding affinity and bone anabolic potential
Gubu, A., Ma, Y., Yu, S., Zhang, H., Chen, Z., Ni, S., Abdullah, R., Xiao, H., Zhang, Y., Dai, H., Luo, H., Yu, Y., Wang, L., Jiang, H., Zhang, N., Tian, Y., Li, H., Lu, A., Zhang, B. & Zhang, G., 12 Mar 2024, In: Molecular Therapy Nucleic Acids. 35, 1, 14 p., 102146.Research output: Contribution to journal › Journal article › peer-review
Open Access1 Citation (Scopus) -
A bimolecular modification strategy for developing long-lasting bone anabolic aptamer
Zhang, H., Yu, S., Ni, S., Gubu, A., Ma, Y., Zhang, Y., Li, H., Wang, Y., Wang, L., Zhang, Z., Yu, Y., Lyu, A., Zhang, B. & Zhang, G., 12 Dec 2023, In: Molecular Therapy - Nucleic Acids. 34, 18 p., 102073.Research output: Contribution to journal › Journal article › peer-review
Open Access1 Citation (Scopus)
Prizes
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2023 Geneva international inventions: silver prize
MA, Yuan (Recipient) & YU, Yuanyuan (Recipient), 29 Apr 2023
Prize
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An aptamer drug targeting sclerostin loop3 for bone anabolic therapy without increasing cardiovascular risk
YU, Yuanyuan (Recipient), Apr 2023
Prize: Award
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First runner-up, Best Poster Award, The Blue Sky Research Fund Open Forum, HKBU
YU, Yuanyuan (Recipient), 2022
Prize: Award
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President’s Award for Outstanding Performance in Early Career Researcher
YU, Yuanyuan (Recipient), 2024
Prize: Award
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Activities
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International Journal of Biological Macromolecules (Journal)
Yuanyuan YU (Reviewer)
Mar 2024Activity: Publication peer-review/editorial work › Editor/reviewer for publications (incl. CDCF T61 Journal Editor)
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Journal of Bone Oncology (Journal)
Yuanyuan YU (Reviewer)
2024 → …Activity: Publication peer-review/editorial work › Editor/reviewer for publications (incl. CDCF T61 Journal Editor)
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Therapeutic Aptamer Targeting Dickkopf-1 for Triple Negative Breast Cancer Therapy
Yuanyuan YU (Speaker)
20 Mar 2024 → 21 Mar 2024Activity: Conference/talk/lecture/symposium/speech/workshop, etc › Event organized by non-HKBU units
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Therapeutic Aptamer Targeting Sclerostin Loop3 for Promoting Bone Formation without Increasing Cardiovascular Risk
Yuanyuan YU (Speaker)
18 Mar 2024 → 19 Mar 2024Activity: Conference/talk/lecture/symposium/speech/workshop, etc › Event organized by non-HKBU units
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Expert Opinion on Drug Discovery (Journal)
Yuanyuan YU (Reviewer)
1 Mar 2023Activity: Publication peer-review/editorial work › Editor/reviewer for publications (incl. CDCF T61 Journal Editor)
Press/Media
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From Molecular Target to Aptamer Drug Discovery towards US-FDA Orphan Drug Designation
Yuanyuan YU, Ge ZHANG, Aiping LYU & Luyao WANG
19/12/22 → 20/12/22
4 Media contributions
Press/Media