Projects per year
Biomolecular modeling and QSPR
After graduated from CUHK with a BSc in Chemistry, I was trained in USA as a computational chemist in the early 90s under the supervision of Prof. B. M. Pettitt focusing on the biomolecular structures and energetics of DNA triple helices. My interests in applying physical principles to biomolecules was further enhanced during my postdoctorate at UT Austin (USA) with Prof. P. J. Rossky on investigating the hydration structures of membrane proteins. When came back to Hong Kong at HKBU til to date, I continued in broadening my exploration in computatonal chemistry to touch on various interdiscplinary topics.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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- 2 Finished
Comparative Binding Studies of Steroids and Novel Ligands of Pharmacological Values to the Glucocorticoid Receptors
1/01/08 → 30/06/11
Project: Research project
Modeling of Polysaccharide-based Chiral Stationary Phase for Enantioseparation by Computational and Experimental Approaches
1/10/04 → 31/03/08
Project: Research project
Huang, X., Thor, W., Feng, X., Kang, L., Yang, M., LEE, C. S., CHENG, Y. K. & He, S., 21 Jan 2020, In: Organic Chemistry Frontiers. 7, 2, p. 255-260 6 p.
Research output: Contribution to journal › Article › peer-review1 Citation (Scopus)
Construction of cyclopenta[: B] pyran-2-ones via chemoselective (3 + 2) cycloaddition between 2-pyrones and vinyl cyclopropanesLiang, X., Ye, W., Thor, W., Sun, L., Wang, B., He, S., CHENG, Y. K. & LEE, C. S., 21 Mar 2020, In: Organic Chemistry Frontiers. 7, 6, p. 840-845 6 p.
Research output: Contribution to journal › Article › peer-review5 Citations (Scopus)
Cao, J., Thor, W., Yang, S., Zhang, M., Bao, W., Zhu, L., Yang, W., CHENG, Y. K. & LEE, C. S., 21 Jun 2019, In: Organic Letters. 21, 12, p. 4896-4899 4 p.
Research output: Contribution to journal › Article › peer-review3 Citations (Scopus)
Ginsenoside Rg3 stereoisomers differentially inhibit vascular smooth muscle cell proliferation and migration in diabetic atherosclerosisGuo, M., Guo, G., Xiao, J., Sheng, X., Zhang, X., Tie, Y., CHENG, Y. K. & Ji, X., Jun 2018, In: Journal of Cellular and Molecular Medicine. 22, 6, p. 3202-3214 13 p.
Research output: Contribution to journal › Article › peer-reviewOpen Access12 Citations (Scopus)
Identification of novel phosphodiesterase-4D inhibitors prescreened by molecular dynamics-augmented modeling and validated by bioassayLi, Z., Cai, Y. H., CHENG, Y. K., Lu, X., Shao, Y. X., Li, X., Liu, M., Liu, P. & Luo, H. B., 22 Apr 2013, In: Journal of Chemical Information and Modeling. 53, 4, p. 972-981 10 p.
Research output: Contribution to journal › Article › peer-review31 Citations (Scopus)