Projects per year
Personal profile
Chinese Name
鄭元傑
Research Interests
Biomolecular modeling and QSPR
Biography
After graduated from CUHK with a BSc in Chemistry, I was trained in USA as a computational chemist in the early 90s under the supervision of Prof. B. M. Pettitt focusing on the biomolecular structures and energetics of DNA triple helices. My interests in applying physical principles to biomolecules was further enhanced during my postdoctorate at UT Austin (USA) with Prof. P. J. Rossky on investigating the hydration structures of membrane proteins. When came back to Hong Kong at HKBU til to date, I continued in broadening my exploration in computatonal chemistry to touch on various interdiscplinary topics.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Dive into the research topics where Yuen Kit CHENG is active. Topic labels come from the works of this scholar.
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Equipment Matching Fund - GPU cluster for largescale biomolecular simulations, drug screening, protein structure prediction, and protein design
ZENG, X. (PI), TANG, Q. (CoI), XIA, Y. (CoI), HAN, W. (CoI), CHENG, Y. K. (CoI) & ZHOU, C. (CoI)
26/03/24 → 25/03/26
Project: Research project
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Comparative Binding Studies of Steroids and Novel Ligands of Pharmacological Values to the Glucocorticoid Receptors
CHENG, Y. K. (PI)
1/01/08 → 30/06/11
Project: Research project
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Modeling of Polysaccharide-based Chiral Stationary Phase for Enantioseparation by Computational and Experimental Approaches
CHENG, Y. K. (PI)
1/10/04 → 31/03/08
Project: Research project
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Synthesis of the Tricyclic Picrotoxane Motif by an Oxidative Cascade Cyclization
Cao, J., Thor, W., Yang, S., Zhang, M., Bao, W., Zhu, L., Yang, W., Cheng, Y. K. & Lee, C. S., 21 Jun 2019, In: Organic Letters. 21, 12, p. 4896-4899 4 p.Research output: Contribution to journal › Journal article › peer-review
18 Citations (Scopus) -
Ginsenoside Rg3 stereoisomers differentially inhibit vascular smooth muscle cell proliferation and migration in diabetic atherosclerosis
Guo, M., Guo, G., Xiao, J., Sheng, X., Zhang, X., Tie, Y., Cheng, Y. K. & Ji, X., Jun 2018, In: Journal of Cellular and Molecular Medicine. 22, 6, p. 3202-3214 13 p.Research output: Contribution to journal › Journal article › peer-review
Open Access28 Citations (Scopus) -
Identification of novel phosphodiesterase-4D inhibitors prescreened by molecular dynamics-augmented modeling and validated by bioassay
Li, Z., Cai, Y. H., Cheng, Y. K., Lu, X., Shao, Y. X., Li, X., Liu, M., Liu, P. & Luo, H. B., 22 Apr 2013, In: Journal of Chemical Information and Modeling. 53, 4, p. 972-981 10 p.Research output: Contribution to journal › Journal article › peer-review
40 Citations (Scopus) -
An update view on the substrate recognition mechanism of phosphodiesterases: A computational study of PDE10 and PDE4 bound with cyclic nucleotides
Lau, J. K. C. & Cheng, Y. K., Nov 2012, In: Biopolymers. 97, 11, p. 910-922 13 p.Research output: Contribution to journal › Journal article › peer-review
2 Citations (Scopus) -
A substrate selectivity and inhibitor design lesson from the PDE10-cAMP crystal structure: A computational study
Lau, J.K.-C., Li, X.-B. & Cheng, Y.-K., 22 Apr 2010, In: Journal of Physical Chemistry B. 114, 15, p. 5154-5160 7 p.Research output: Contribution to journal › Journal article › peer-review
Open AccessFile4 Citations (Scopus)27 Downloads (Pure)