Personal profile
Chinese Name
Biography
Xiangze Zeng is currently an Assistant Professor in the physics department with an affiliated position in the School of Chinese Medicine at Hong Kong Baptist University. He obtained his BSc in physics at Shandong University in 2013. Then he did his PhD study in the chemistry department at Hong Kong University of Science and Technology from 2013 to 2017. After that, he got postdoc training at Washington University in St. Louis.
Xiangze is interested in studying the kinetics and thermodynamics of biomolecules at the atomic and molecular level. He aims to uncover the molecular mechanism of different molecular processes, using computer simulations (all-atom and coarse-grained simulations), mathematical modelling, and close collaborations with experimentalists.
Research Interests
Computational biophysics
Intrinsically disordered proteins
Biomolecular condensates
Phase separation in biology
Protein-protein/ligand interactions
Molecular dynamics and Monte Carlo simulations
Multiscale modeling
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Collaborations and top research areas from the last five years
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天然无序蛋白质中氨基酸残基相互作用模式的保守性及其功能关联性研究
ZENG, X. (PI), CHEN, F. (Collaborator) & GAO, Y. (Collaborator)
1/01/26 → 31/12/28
Project: Research project
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The 6th Symposium on Biophysics Postgraduate Research in Hong Kong
ZENG, X. (PI)
6/01/24 → 6/01/24
Project: Research project
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Asymmetry in Hydrophobicity Induces Electric Potential in Non-Charged Biomolecular Condensates
Yang, L., Yu, W., Zeng, X. & Dai, Y., 9 Feb 2026, (E-pub ahead of print) In: Advanced Science. 12 p., e24324.Research output: Contribution to journal › Journal article › peer-review
Open Access3 Citations (Scopus) -
Backbone-mediated weakening of pairwise interactions enables percolation in peptide-based mimics of protein condensates
Zeng, X. & Pappu, R. V., 6 Apr 2025, In: Communications Chemistry. 8, 1, 14 p., 106.Research output: Contribution to journal › Journal article › peer-review
Open Access3 Citations (Scopus) -
Phenomenological Model for the Efficient General Regulatory Role of Metabolites
Wu, X., Chen, L., Hu, G., Ou, X., Zeng, X., Shi, R. & Li, J., 17 Jul 2025, In: Journal of Physical Chemistry B. 129, 28, p. 7079-7087 9 p.Research output: Contribution to journal › Journal article › peer-review
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Recent advances in the synthesis and application of biomolecular condensates
Li, Z., Tan, W., Zhao, G.-P., Zeng, X. & Zhao, W., Feb 2025, In: Journal of Biological Chemistry. 301, 2, 14 p., 108188.Research output: Contribution to journal › Journal article › peer-review
Open Access4 Citations (Scopus) -
Staudinger Reaction-Responsive Coacervates for Cytosolic Antibody Delivery and TRIM21-Mediated Protein Degradation
Bao, Y., Xu, Z., Cheng, K., Li, X., Chen, F., Yuan, D., Zhang, F., Che, A.R.-Y., Zeng, X., Zhao, Y.-D. & Xia, J., 29 Jan 2025, In: Journal of the American Chemical Society. 147, 4, p. 3830-3839 10 p.Research output: Contribution to journal › Journal article › peer-review
Open Access8 Citations (Scopus)
Activities
- 3 Editor/reviewer for publications (incl. CDCF T61 Journal Editor)
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Biophysical Journal (Journal)
ZENG, X. (Reviewer)
1 Mar 2025 → 30 Jun 2025Activity: Publication peer-review/editorial work › Editor/reviewer for publications (incl. CDCF T61 Journal Editor)
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Journal of Chemical Information and Modeling (Journal)
ZENG, X. (Reviewer)
1 Nov 2025 → 31 Dec 2025Activity: Publication peer-review/editorial work › Editor/reviewer for publications (incl. CDCF T61 Journal Editor)
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Journal of the American Chemical Society (Journal)
ZENG, X. (Reviewer)
1 Nov 2024 → 31 Dec 2025Activity: Publication peer-review/editorial work › Editor/reviewer for publications (incl. CDCF T61 Journal Editor)