Projects per year
Personal profile
Chinese Name
Biography
Dr. Wong holds Bachelor of Science (Bsc) from the University of Hong Kong. He pursued PhD in Biochemistry at Department of Biochemistry in the University of Hong Kong.
Dr. Wong serves as a principal investigator at the School of Chinese Medicine in Hong Kong Baptist University, leading a team with expertise in biology, neuroscience and microbiome. In the capacity of first/corresponding author, his works have been published in prestigious journals, including Cell Host & Microbe (1), Nature Metabolism (1), Nature Communications (5) and Developmental Cell (1). Dr. Wong has obtained the funding support from the National Natural Science Foundation of China’s Excellent Young Scientists Scheme (Hong Kong & Macao).
Research Interests
My laboratory focuses on systematic characterization of proteases to understand the regulation of cell biology; metabolic biology to control cellular disease phenotypes suggested by human genetics; molecular mechanisms to determine roles of the microbiome in health and disease; and the molecular mechanisms uncovering patterns of human and microbial pathway regulation during disease and treatment.
Selected publications (# correspondence)
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Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
PhD, Department of Biochemistry, The University of Hong Kong
Award Date: 1 Oct 2013
Bachelor, Biochemistry & Biotechnology, School of Biological Sciences, Faculty of Science, The University of Hong Kong
Award Date: 1 Oct 2009
Keywords
- QP Physiology
- Cell Metabolism
- Cell signaling
- RB Pathology
- diabetes
- obesity
- QR180 Immunology
- Microbiome
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Collaborations and top research areas from the last five years
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Dissecting the Therapeutic Role of 3A2 Antibody for the Treatment of Obesity and Type 2 Diabetes
3/10/23 → 30/04/26
Project: Research project
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Dissecting the Therapeutic Role of 3A2 Antibody for the Treatment of Obesity and Type 2 Diabetes
8/09/23 → 31/03/25
Project: Research project
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Dissecting the Therapeutic Role of 3A2 Antibody for the Treatment of Obesity and Type 2 Diabetes
1/05/23 → 30/04/26
Project: Research project
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Investigating the role of ADAM9 in the regulation of body weight and food intake
3/01/22 → 2/01/25
Project: Research project
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To investigate the role of klotho shedding in the ageing process
1/01/21 → 31/12/23
Project: Research project
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Regulation of age-associated insulin resistance by MT1-MMP-mediated cleavage of insulin receptor
Guo, X., Asthana, P., Gurung, S., Zhang, S., Wong, S. K. K., Fallah, S., Chow, C. F. W., Che, S., Zhai, L., Wang, Z., Ge, X., Jiang, Z., Wu, J., Zhang, Y., Wu, X., Xu, K., Lin, C. Y., Kwan, H. Y., Lyu, A., Zhou, Z., & 2 others , 29 Jun 2022, In: Nature Communications. 13, 1, 10 p., 3749.Research output: Contribution to journal › Journal article › peer-review
Open Access11 Citations (Scopus) -
Body weight regulation via MT1-MMP-mediated cleavage of GFRAL
Chow, C. F. W., Guo, X., Asthana, P., Zhang, S., Wong, S. K. K., Fallah, S., Che, S., Gurung, S., Wang, Z., Lee, K. B., Ge, X., Yuan, S., Xu, H., Ip, J. P. K., Jiang, Z., Zhai, L., Wu, J., Zhang, Y., Mahato, A. K., Saarma, M., & 7 others , 17 Feb 2022, In: Nature Metabolism. 4, 2, p. 203–212 10 p.Research output: Contribution to journal › Journal article › peer-review
15 Citations (Scopus) -
Ruminococcus gnavus plays a pathogenic role in diarrhea-predominant irritable bowel syndrome by increasing serotonin biosynthesis
Zhai, L., Huang, C., Ning, Z., Zhang, Y., Zhuang, M., Yang, W., Wang, X., Wang, J., Zhang, L., Xiao, H., Zhao, L., Asthana, P., Lam, Y. Y., Chow, C. F. W., Huang, J. D., Yuan, S., Chan, K. M., Yuan, C. S., Lau, J. Y. N., Wong, H. L. X., & 1 others , 11 Jan 2023, In: Cell Host and Microbe. 31, 1, p. 33-44.e5 12 p.Research output: Contribution to journal › Journal article › peer-review
12 Citations (Scopus) -
Control of SARS-CoV-2 infection by MT1-MMP-mediated shedding of ACE2
Guo, X., Cao, J., Cai, J. P., Wu, J., Huang, J., Asthana, P., Wong, S. K. K., Ye, Z. W., Gurung, S., Zhang, Y., Wang, S., Wang, Z., Ge, X., Kwan, H. Y., Lyu, A., Chan, K. M., Wong, N., Huang, J., Zhou, Z., Bian, Z. X., & 2 others , 23 Dec 2022, In: Nature Communications. 13, 17 p., 7907.Research output: Contribution to journal › Journal article › peer-review
Open Access3 Citations (Scopus) -
Early life stress disrupts intestinal homeostasis via NGF-TrkA signaling
Wong, H. L. X., Qin, H. Y., Tsang, S. W., Zuo, X., Che, S., Chow, C. F. W., Li, X., Xiao, H. T., Zhao, L., Huang, T., Lin, C. Y., Kwan, H. Y., Yang, T., Longo, F. M., Lyu, A. & Bian, Z. X., Dec 2019, In: Nature Communications. 10, 1745.Research output: Contribution to journal › Journal article › peer-review
Open Access35 Citations (Scopus)
Prizes
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President's Award for Outstanding Performance as Early Career Researcher
WONG, Hoi Leong Xavier (Recipient), 2022
Prize: Award
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Activities
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Metabolites (Journal)
Hoi Leong Xavier WONG (Reviewer)
2023Activity: Publication peer-review/editorial work › Editor/reviewer for publications (incl. CDCF T61 Journal Editor)
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Nutrients (Journal)
Hoi Leong Xavier WONG (Reviewer)
2023Activity: Publication peer-review/editorial work › Editor/reviewer for publications (incl. CDCF T61 Journal Editor)
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Frontiers in Pharmacology (Journal)
Hoi Leong Xavier WONG (Reviewer)
2023Activity: Publication peer-review/editorial work › Editor/reviewer for publications (incl. CDCF T61 Journal Editor)
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Journal of Cellular and Molecular Medicine (Journal)
Hoi Leong Xavier WONG (Reviewer)
2023Activity: Publication peer-review/editorial work › Editor/reviewer for publications (incl. CDCF T61 Journal Editor)
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Pharmaceuticals (Journal)
Hoi Leong Xavier WONG (Reviewer)
2023Activity: Publication peer-review/editorial work › Editor/reviewer for publications (incl. CDCF T61 Journal Editor)
Press/Media
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Press conference on cell entry mechanism of SARS-CoV-2 and therapeutic target for COVID-19
20/03/23
1 item of Media coverage
Press/Media
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Press conference on the new regulatory mechanism of satiety and therapeutic target for obesity research
Hoi Leong Xavier WONG & Zhaoxiang BIAN
30/05/22 → 31/05/22
5 items of Media coverage, 1 Media contribution
Press/Media