Research activity per year

If you made any changes in Pure these will be visible here soon.

Personal profile

Chinese Name



Dr. Wong holds Bachelor of Science (Bsc) from the University of Hong Kong. He pursued PhD in Biochemistry at Department of Biochemistry in the University of Hong Kong. 

Dr. Wong serves as a principal investigator at the School of Chinese Medicine in Hong Kong Baptist University, leading a team with expertise in biology, neuroscience and microbiome. In the capacity of first/corresponding author, his works have been published in prestigious journals, including Cell Host & Microbe (1), Nature Metabolism (1), Nature Communications (5) and Developmental Cell (1). Dr. Wong has obtained the funding support from the National Natural Science Foundation of China’s Excellent Young Scientists Scheme (Hong Kong & Macao). 

Research Interests

My laboratory focuses on systematic characterization of proteases to understand the regulation of cell biology; metabolic biology to control cellular disease phenotypes suggested by human genetics; molecular mechanisms to determine roles of the microbiome in health and disease; and the molecular mechanisms uncovering patterns of human and microbial pathway regulation during disease and treatment.

Selected publications (# correspondence)

1.     Zhai L*, Xiao H*, Lin CY*, Wong HLX* (*co-first), Lam YY, Gong M, Wu G, Deng Y, Ning Z, Huang C, Zhang Y, Zhuang M, Yang C, Luo J, Zhang EL, Zhao L, Zhang C, Fang Z, Lau JYN, Jia W, Zhao L, Bian Z. (2023) Gut microbiota-derived tryptamine and phenethylamine impair insulin sensitivity in metabolic syndrome and irritable bowel syndrome. Nature Communications [Impact factor: 17.694]

2.     Guo X, Cao J, Wu J, Huang J, Asthana P, Wong SKK, Gurung S, Zhang Y, Wang S, Kwan HY, Lyu A, Chan KM, Huang JD, Zhou Z, Bian ZX, Yuan S, Wong HLX# (2022) Control of SARS-CoV-2 infection by MT1-MMP-mediated shedding of ACE2.  Nature Communications [Impact factor: 17.694]

3.     Zhai L, Huang C, Ning Z, Zhang Y, Zhuang M, Yang W, Wang X, Zhang EL, Xiao H, Zhao L, Lam YY, Chow CFW, Huang J, Yuan S, Chan KM, Yuan CS, Lau JYN, Wong HLX# (co-correspondence), Bian Z# (2022) Ruminococcus gnavus plays a pathogenic role in diarrhea-predominant irritable bowel syndrome by increasing serotonin biosynthesis. Cell Host & Microbe [Impact factor: 31.316]

4.     Guo X, Asthana P, Zhang S, Gurung S, Wong SKK, Fallah S, Chow CFW, Che S, Zhai L, Wang Z, Xin G, Jiang Z, Wu J, Zhang Y, Wu X, Xu K, Lin CY, Kwan HY, Lyu A, Zhou Z, Bian Z, Wong HLX# (2022) Regulation of age-associated insulin resistance by MT1-MMP-mediated cleavage of Insulin Receptor. Nature Communications 13, 3749 [Impact factor: 17.694]

5.     Chow CFW*, Guo X*, Asthana P*, Zhang S, Fallah S, Che S, Wang Z, Ge X, Jiang Z, Zhai L, Lin CY, Kwan HY, Huang T, Lyu A, Zhou Z, Bian Z, Wong HLX# (2022) Body weight regulation via MT1-MMP-mediated cleavage of GFRAL. Nature Metabolism 4, 203-212 [Impact factor: 19.865]

  •  Highlights of the Issue in Nature Metabolism - [Central regulation of the anorexigenic receptor GFRAL]
  • Research Highlights of Nature Reviews Endocrinology- [Negative regulator of GDF15 signaling identified]
  • Editor’s choice of Science Signaling - [Cutting down in size by not making a cut]

6.     Wong HLX, Qin H, Tsang SW, Zuo X, Che S, Chow CFW, Li X. Xiao HT, Zhao L, Huang T, Lin CY, Kwan HY, Yang T, Longo FM, Lyu A, Bian Z (2019) Early life stress disrupts intestinal homeostasis via NGF-TrkA signaling. Nature Communications 10(1):1745 [Impact factor: 17.694]

7.     Wong HLX, Jin G, Zhang S, Cao R, Cao Y, Zhou Z (2016) MT1-MMP sheds LYVE-1 on lymphatic endothelial cells and suppresses VEGF-C production to inhibit lymphangiogenesis. Nature Communications 7:10824 [Impact factor: 17.694]

8.     Chan KM*, Wong HLX* (*co-first), Jin G, Liu B, Cao R, Cao Y, Lehtl K, Tryggvason K and Zhou Z (2012). MT1-MMP inactivates ADAM9 to regulate FGFR2 signaling in calvarial osteogenesis. Developmental Cell, 22(6); 1176-1190 [Impact factor: 13.417]

  • [recommended in F1000 Prime, F1000 factor 8.0]



Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Education/Academic qualification

PhD, Department of Biochemistry, The University of Hong Kong

Award Date: 1 Oct 2013

Bachelor, Biochemistry & Biotechnology, School of Biological Sciences, Faculty of Science, The University of Hong Kong

Award Date: 1 Oct 2009


  • QP Physiology
  • Cell Metabolism
  • Cell signaling
  • RB Pathology
  • diabetes
  • obesity
  • QR180 Immunology
  • Microbiome


Dive into the research topics where Hoi Leong Xavier WONG is active. Topic labels come from the works of this scholar.
  • 1 Similar Scholars

Collaborations and top research areas from the last five years

Recent external collaboration on country/territory level. Dive into details by clicking on the dots or