Projects per year
My research interest focuses on microbial metabolomics and host-gut microbe metabolic interactions that underlie the development of gastrointestinal diseases and metabolic disorders and the treatment of these conditions using small molecule compounds, natural products, and traditional Chinese medicines. His group currently operates a world-class metabolomics laboratory, to quantitatively determine endogenous small-molecule metabolites and trace elements, supporting translational research in cancer biology, drug discovery, and traditional Chinese medicine.
My long-term research goals are to continue to conduct high-quality, peer-reviewed, grant-funded original research in the areas of cancer metabolism and biomarker discovery in collaboration with clinicians, bioinformaticians and epidemiologists. My research interest involves defining the molecular mechanisms that link metabolic disruptions in gut microbial-host co-metabolism to gastrointestinal diseases and metabolic disorders such as diabetes.My current research program combines a series of metabolomics, microbiome, bioinformatics, and molecular biology approaches to the identification of cancer etiology in a variety of tumor types and the mechanistic studies of key metabolic pathways that are critically involved during carcinogenesis. Throughout my career I have worked closely with basic and translational researchers, and clinical colleagues and served as mentor to many PhD/MD candidates.
My laboratory focused on the development and clinical application of metabolomics methods starting in 2003, when the field of metabolomics was just emerging. Our lab currently operates a state-of-art metabolomics program that quantitatively profiles endogenous small-molecule metabolites and trace elements from biological specimens including blood, urine, saliva, cell lysates, and tissues of experimental animals and human subjects.
The program involves:
- Targeted analysis of metabolic flux and pathways using isotope labeled metabolites and high sensitivity, high throughput LC-MS-MS and GC-MS platforms,
- Unbiased metabolic profiling and data mining, metabolite annotation and biological interpretation,
- A fully automated, high-throughput platform that quantitatively profiles microbial metabolome coupled with bioinformatics capable of integrating into metagenomic data to provide the functional translation of the microbiome.
- Classification and prediction of disease phenotypes based on their unique metabolic signatures for patient stratification and personalized treatment.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Taught Post-Graduate, Public Relationship, Fudan University
Bachelor, Analytical Chemistry, Jiangnan University
Master, Radiopharmaceutical Science, University of Missouri – Columbia
PhD, Radiopharmaceutical Science, University of Missouri – Columbia
Director Center for Translational Medicine, Shanghai Sixth People's Hospital Shanghai Jiao Tong University
Oct 2012 → …
Professor, Shanghai Jiao Tong University affiliated 6th People's Hospital
Oct 2012 → …
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- 2 Not started
1/01/24 → 1/12/26
Project: Research project
Project: Research project
Yu, L., Huang, C., Yang, W., Ren, Z., Li, L., Cheng, H., Lin, C., Zhai, L., Ning, Z., Wong, H. X., Han, Q., Jia, W., Bian, Z. & Zhao, L., 9 Jan 2023, In: Frontiers in Pharmacology. 13, 11 p., 1010484.
Research output: Contribution to journal › Journal article › peer-reviewOpen Access1 Citation (Scopus)
BCKDK, a novel hypoxia-responsive factor/kinase that exacerbates cerebral ischemia injury (Abstract)Liao, B., Geng, L., Jia, W. & Hoo, R. L. C., 10 Oct 2023, In: International Journal of Stroke. 18, 3, suppl., p. 345-346 2 p.
Research output: Contribution to journal › Conference articleOpen Access
Cheung, K. C. P., Ma, J., Loiola, R. A., Chen, X. & Jia, W., Aug 2023, In: European Journal of Immunology. 53, 8, 14 p., 2250299.
Research output: Contribution to journal › Review article › peer-reviewOpen Access
Jia, W., Li, Y., Cheung, K. C. P. & Zheng, X., 27 Jul 2023, (E-pub ahead of print) In: Science China Life Sciences.
Research output: Contribution to journal › Journal article › peer-review2 Citations (Scopus)
Extracellular vesicles derived from host and gut microbiota as promising nanocarriers for targeted therapy in osteoporosis and osteoarthritisCheung, K. C. P., Ma, J., Chen, X. & Jia, W., 6 Jan 2023, In: Frontiers in Pharmacology. 13, 14 p., 1051134.
Research output: Contribution to journal › Journal article › peer-reviewOpen Access2 Citations (Scopus)
JIA, Wei (Recipient), 2021
JIA, Wei (Recipient), 2020
JIA, Wei (Recipient), 2022
JIA, Wei (Recipient), 2016
JIA, Wei (Recipient), 2023