Projects per year
Personal profile
Chinese Name
Research Interests
My research interest focuses on microbial metabolomics and host-gut microbe metabolic interactions that underlie the development of gastrointestinal diseases and metabolic disorders and the treatment of these conditions using small molecule compounds, natural products, and traditional Chinese medicines. His group currently operates a world-class metabolomics laboratory, to quantitatively determine endogenous small-molecule metabolites and trace elements, supporting translational research in cancer biology, drug discovery, and traditional Chinese medicine.
Biography
My long-term research goals are to continue to conduct high-quality, peer-reviewed, grant-funded original research in the areas of cancer metabolism and biomarker discovery in collaboration with clinicians, bioinformaticians and epidemiologists. My research interest involves defining the molecular mechanisms that link metabolic disruptions in gut microbial-host co-metabolism to gastrointestinal diseases and metabolic disorders such as diabetes.My current research program combines a series of metabolomics, microbiome, bioinformatics, and molecular biology approaches to the identification of cancer etiology in a variety of tumor types and the mechanistic studies of key metabolic pathways that are critically involved during carcinogenesis. Throughout my career I have worked closely with basic and translational researchers, and clinical colleagues and served as mentor to many PhD/MD candidates.
My laboratory focused on the development and clinical application of metabolomics methods starting in 2003, when the field of metabolomics was just emerging. Our lab currently operates a state-of-art metabolomics program that quantitatively profiles endogenous small-molecule metabolites and trace elements from biological specimens including blood, urine, saliva, cell lysates, and tissues of experimental animals and human subjects.
The program involves:
- Targeted analysis of metabolic flux and pathways using isotope labeled metabolites and high sensitivity, high throughput LC-MS-MS and GC-MS platforms,
- Unbiased metabolic profiling and data mining, metabolite annotation and biological interpretation,
- A fully automated, high-throughput platform that quantitatively profiles microbial metabolome coupled with bioinformatics capable of integrating into metagenomic data to provide the functional translation of the microbiome.
- Classification and prediction of disease phenotypes based on their unique metabolic signatures for patient stratification and personalized treatment.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Taught Post-Graduate, Public Relationship, Fudan University
Bachelor, Analytical Chemistry, Jiangnan University
Master, Radiopharmaceutical Science, University of Missouri – Columbia
PhD, Radiopharmaceutical Science, University of Missouri – Columbia
External positions
Director Center for Translational Medicine, Shanghai Sixth People's Hospital Shanghai Jiao Tong University
Oct 2012 → …
Professor, Shanghai Jiao Tong University affiliated 6th People's Hospital
Oct 2012 → …
Fingerprint
- 1 Similar Scholars
Collaborations and top research areas from the last five years
Projects
- 2 Not started
-
Investigating and examining the role of Hyocholic acid signalling in athero-immunometabolism
CHEUNG, K. C. P., JIA, W. & Xiao, Q.
1/01/24 → 1/12/26
Project: Research project
-
Dysregulated Host - Gut Microbiota Co-Metabolism in Metabolic Associated Fatty Liver Disease
Project: Research project
-
Aqueous cinnamon extract ameliorates bowel dysfunction and enteric 5-HT synthesis in IBS rats
Yu, L., Huang, C., Yang, W., Ren, Z., Li, L., Cheng, H., Lin, C., Zhai, L., Ning, Z., Wong, H. X., Han, Q., Jia, W., Bian, Z. & Zhao, L., 9 Jan 2023, In: Frontiers in Pharmacology. 13, 11 p., 1010484.Research output: Contribution to journal › Journal article › peer-review
Open Access -
BCKDK, a novel hypoxia-responsive factor/kinase that exacerbates cerebral ischemia injury
Liao, B. & Jia, W., 10 Oct 2023.Research output: Contribution to conference › Conference poster
-
Bile acid-activated receptors in innate and adaptive immunity: targeted drugs and biological agents
Cheung, K. C. P., Ma, J., Loiola, R. A., Chen, X. & Jia, W., Aug 2023, In: European Journal of Immunology. 53, 8, 14 p., 2250299.Research output: Contribution to journal › Review article › peer-review
Open Access -
Bile acid signaling in the regulation of whole body metabolic and immunological homeostasis
Jia, W., Li, Y., Cheung, K. C. P. & Zheng, X., 27 Jul 2023, (E-pub ahead of print) In: Science China Life Sciences.Research output: Contribution to journal › Journal article › peer-review
-
Extracellular vesicles derived from host and gut microbiota as promising nanocarriers for targeted therapy in osteoporosis and osteoarthritis
Cheung, K. C. P., Ma, J., Chen, X. & Jia, W., 6 Jan 2023, In: Frontiers in Pharmacology. 13, 14 p., 1051134.Research output: Contribution to journal › Journal article › peer-review
Open Access1 Citation (Scopus)
Prizes
-
-
-
-
Natural Science Award 2016, Shanghai Municipal Government, China, 2016
JIA, Wei (Recipient), 2016
Prize: Award
-
President’s Award for Outstanding Performance in Scholarly Work in 2023
JIA, Wei (Recipient), 2023
Prize: Award
Activities
-
病證結合推動中西醫融合發展學術研討會
Wei JIA (Organiser)
17 Mar 2023Activity: Conference/talk/lecture/symposium/speech/workshop, etc › Event organized by non-HKBU units
-
浙江省人民醫院訪問團訪問安排
Wei JIA (Organiser)
16 Mar 2023Activity: Conference/talk/lecture/symposium/speech/workshop, etc › Event organized by non-HKBU units
-
省部共建中醫濕證國家重點實驗室名師講座
Wei JIA (Organiser)
27 Mar 2023Activity: Conference/talk/lecture/symposium/speech/workshop, etc › Event organized by non-HKBU units
-
第三届福民內分泌代謝論壇
Wei JIA (Organiser)
24 Sept 2022Activity: Conference/talk/lecture/symposium/speech/workshop, etc › Event organized by non-HKBU units
-
第三届粤港澳大湾区发展论坛暨颁奖典礼
Wei JIA (Organiser)
24 Oct 2022Activity: Conference/talk/lecture/symposium/speech/workshop, etc › Event organized by non-HKBU units