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Biography
Professor Thomas Knöpfel, Chair Professor, Department of Physics, Director of JC STEM laboratory of Neuronal Circuit Dynamics. He graduated both in Physics and Medicine at the Ulm University (Germany) and promoted at the University of Zürich (Switzerland), where he also served as assistant and associate professor before acquiring some experience in drug discovery at Swiss Big Pharma. In 1997 Thomas Knöpfel relocated to Japan to head the Laboratory for. Neuronal Circuit Dynamics at the newly established RIKEN Brain Science Institute. In 2013 he became Chair in Optogenetics and Circuit Neurosciences at Imperial College (UK). Prof Knöpfel joined HKBU 2023. He has published over 230 research papers in journals such as Nature, Nature Methods, Nature Communications, PNAS, J Neuroscience, J Neurophysiology, Cerebral Cortex. Notable reviews were published in Nature Review Neuroscience and Nature Review Drug Discovery.
Research Interests
Professor Knöpfel research interest revolve around the fundamental question how the brain generates cognition and emotions. What defines as, from a natural science perspective, to be human? On the practical level, his experimental work make good use of the opportunities offered by optical imaging technologies and genetics. He actively collaborates with theoretical neuroscientists to unravel neuronal circuit mechanism.
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Collaborations and top research areas from the last five years
Projects
- 1 Active
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Lasting effect of psilocybin on sociability can be blocked by DNA methyltransferase inhibition
Song, C., Chang, T., Buchborn, T. & Knöpfel, T., 11 Mar 2025, Cold Spring Harbor Laboratory Press, (bioRxiv).Research output: Working paper › Preprint
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Psychedelic 5-HT2A agonist increases spontaneous and evoked 5-Hz oscillations in visual and retrosplenial cortex
White, C. M., Azimi, Z., Staadt, R., Song, C., Knöpfel, T. & Jancke, D., 6 Jul 2025, Cold Spring Harbor Laboratory Press, 16 p. (bioRxiv).Research output: Working paper › Preprint
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Characterization of two near-infrared genetically encoded voltage indicators
Song, C., Matlashov, M. E., Shcherbakova, D. M., Antic, S. D., Antic, S. D., Verkhusha, V. V. & Knöpfel, T., Apr 2024, In: Neurophotonics. 11, 2, 10 p., 024201.Research output: Contribution to journal › Journal article › peer-review
Open Access2 Citations (Scopus) -
Complexity of cortical wave patterns of the wake mouse cortex
Liang, Y., Liang, J., Song, C., Liu, M., Knöpfel, T., Gong, P. & Zhou, C., 15 Mar 2023, In: Nature Communications. 14, 13 p., 1434.Research output: Contribution to journal › Journal article › peer-review
Open Access21 Citations (Scopus) -
Cortical Correlates of Psychedelic-Induced Shaking Behavior Revealed by Voltage Imaging
Buchborn, T., Lyons, T., Song, C., Feilding, A. & Knöpfel, T., 1 Jun 2023, In: International Journal of Molecular Sciences. 24, 11, 15 p., 9463.Research output: Contribution to journal › Journal article › peer-review
Open Access4 Citations (Scopus)