Research output per year
Research output per year
Personal profile
Chinese Name
馬元
Biography
Dr. Ma Yuan graduated with a Ph.D. in Medicinal Chemistry from the Peking University Health Science Center in 2019. In the same year, he was appointed as an associate researcher at the Meng Chao Hepatobiliary Hospital of Fujian Medical University, focusing on early diagnosis and clinical research of new treatments for liver cancer. In 2020, he joined the School of Chinese Medicine at Hong Kong Baptist University as a postdoctoral researcher and was promoted to research assistant professor in 2022. He is dedicated to exploring the use of small nucleic acid drugs for cancer diagnosis and treatment, as well as targeted therapy in the modernization of traditional Chinese medicine. In the same year, Dr. Ma was elected as the Secretary-Hong Kong Association of Herbal Pharmacology.
Dr. Ma's research interests over the past decade have focused on the development of natural products and nucleic acid drugs in the fields of oncology and orthopedic diseases. His representative work has been published in journals such as Biomaterials, Frontiers in Cell and Developmental Biology, Colloids and Surfaces B: Biointerfaces, and Organic & Biomolecular Chemistry. He has led or participated in numerous provincial and national funding projects.
Research Interests
1. Aptamer based translation and modernization of natural products
2. Artificial intelligence aided high affinity modification of aptamers
3. Aptamer functionalized nanomedicines for oncology and orthopedic diseases.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
phD
1 Sept 2015 → 5 Jan 2019
M.S., Peking University Health Science Center
1 Sept 2013 → 1 Jul 2015
B.S., Peking University Health Science Center
1 Sept 2009 → 1 Jul 2013
Keywords
- QD Chemistry
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Dive into the research topics where Yuan MA is active. Topic labels come from the works of this scholar.
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Advancing targeted combination chemotherapy in triple negative breast cancer: nucleolin aptamer-mediated controlled drug release
Ma, Y., Xie, D., Chen, Z., Shen, X., Wu, X., Ding, F., Ding, S., Pan, Y., Li, F., Lu, A. & Zhang, G., 1 Jul 2024, In: Journal of Translational Medicine. 22, 1, 13 p., 604.Research output: Contribution to journal › Journal article › peer-review
Open Access -
Aptamer AS411 interacts with the KRAS promoter/hnRNP A1 complex and shows increased potency against drug-resistant lung cancer
Zhu, Y., Li, X., Zhang, Q., Yang, X., Sun, X., Pan, Y., Yuan, X., Ma, Y., Xu, B. & Yang, Z., 1 May 2024, In: RSC Medicinal Chemistry. 15, 5, p. 1515-1526 12 p.Research output: Contribution to journal › Journal article › peer-review
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Aptamer Functionalized Hypoxia-potentiating Agent and Hypoxia-inducible Factor Inhibitor Combined with Hypoxia-activated Prodrug for Enhanced Tumor Therapy
Ma, Y., Zhang, H., Shen, X., Yang, X., Deng, Y., Tian, Y., Chen, Z., Pan, Y., Luo, H., Zhong, C., Yu, S., Lu, A., Zhang, B., Tang, T. & Zhang, G., 28 Aug 2024, In: Cancer Letters. 598, 12 p., 217102.Research output: Contribution to journal › Journal article › peer-review
Open Access -
Design and synthesis of nucleotidyl lipids and their application in the targeted delivery of siG12D for pancreatic cancer therapy
Pan, Y., Zhu, Y., Ma, Y., Hong, J., Zhao, W., Gao, Y., Guan, J., Ren, R., Zhang, Q., Yu, J., Guan, Z. & Yang, Z., Mar 2024, In: Biomedicine and Pharmacotherapy. 172, 14 p., 116239.Research output: Contribution to journal › Journal article › peer-review
Open Access1 Citation (Scopus) -
Intracellular sclerostin plays a vital role in tumor progression and metastasis in triple-negative breast cancer
Sun, M., Qiao, S., Luo, H., Yang, X., Yang, L., Zhang, H., Chen, Z., Wang, L., Tao, X., Yu, Y., Ma, Y., Yuan, F., Ma, D., Chen, Q., Lu, A., Zhang, B. T., Zhang, G. & Li, F., 1 Feb 2024, In: Cancer Research. 84, 3, Supplement 1, B044.Research output: Contribution to journal › Conference article › peer-review
Prizes
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2023 Geneva international inventions: silver prize
MA, Yuan (Recipient) & YU, Yuanyuan (Recipient), 29 Apr 2023
Prize
Activities
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Hong Kong Pharmaceutical Academy (External organisation)
Yuan MA (Secretary)
May 2023 → May 2026Activity: Membership › Membership of board/committee/council
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Frontiers in Cell and Developmental Biology (Journal)
Yuan MA (Guest editor)
2022 → …Activity: Publication peer-review/editorial work › Editor/reviewer for publications (incl. CDCF T61 Journal Editor)
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Hong Kong Association of Herbal Pharmacology Limited (External organisation)
Yuan MA (Secretary)
2022 → …Activity: Membership › Membership of board/committee/council
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Chinese Medicine (Journal)
Yuan MA (Member of editorial board)
15 Oct 2022 → 14 Oct 2024Activity: Publication peer-review/editorial work › Editor/reviewer for publications (incl. CDCF T61 Journal Editor)
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HKBU and IncreasePharm Joint Centre for Nucleic Acid Drug Discovery (Organisational unit)
Yuan MA (Director/non-executive director)
2020 → …Activity: Membership › Membership of board/committee/council