Projects per year
Personal profile
Chinese Name
Biography
Professor Li Min is an acclaimed scholar in the treatment of neurodegenerative diseases using Chinese medicine, currently serving as Dean of School of Chinese Medicine (SCM), Hong Kong Baptist University (HKBU). Joining Hong Kong HKBU in 2001, Professor Li currently holds several positions in SCM: Chair Professor of Chinese Medicine, Ma Pak Leung Endowed Professor in Innovative Neuromedicine, Director of Mr. & Mrs. Ko Chi Ming Centre for Parkinson’s Disease Research (CPDR), Golden Meditech Centre for NeuroRegeneration Sciences (GCNS) and HKBU Musketeers Foundation Traditional Chinese Medicine Research Institute for Age-related Diseases.
With over 40 years of clinical practice, teaching, and research in Chinese medicine, Professor Li specialises in the pharmacological studies and clinical treatment of neurodegenerative diseases such as Parkinson’s disease (PD), Alzheimer’s disease (AD) and Amyotrophic Lateral Sclerosis (ALS) with Chinese medicine, as well as new drug development. She was mentored by Professor Deng Tietao, the first cohort of National Master of Traditional Chinese Medicine (TCM), and Professor Xiong Jibai, the third cohort of National Master of TCM. Professor Li was named the First Cohort of National Outstanding Female Chinese Medicine Practitioner in 2007, and received the HKBU President’s Award for Outstanding Performance in Teaching in 2013 and 2018, as well as the President’s Award for Outstanding Performance in Research Supervision in 2024. She has consistently been ranked among the world’s top 2% scientists by Stanford University in recent years.
Professor Li’s research team has published about 200 high-level academic papers in international journals, including Nature Communications, Autophagy, Signal Transduction and Targeted Therapy, and Aging Cell. She has led a number of research projects funded by the National Natural Science Foundation of China and the Research Grants Council of Hong Kong. She has authored over 20 academic monographs and holds more than 20 patents from the United States, Europe, and China.
李敏,醫學博士,講座教授,馬百良創新神經藥物教授,博士生、博士後導師,為中醫內科學及中醫藥治療老年神經退行性疾病專家。李教授於2001年加入香港浸會大學,目前擔任中醫藥學院院長、高智明伉儷柏金遜症研究中心主任、金衛醫療神經再生研究中心主任以及香港浸會大學同心基金高齡疾病中醫藥研究所主任。
李教授從事中醫臨床、教學和研究工作逾四十年。目前主要從事老年神經退行性疾病(柏金遜症、阿爾茨海默病和肌萎縮側索硬化症等)的中醫臨床治療、中藥藥理研究與新藥研發。曾先後師從第一屆國醫大師鄧鐵濤教授和第三屆國醫大師熊繼柏教授。李教授榮獲 「全國首屆傑出女中醫師」稱號(2007年),獲得香港浸會大學傑出教學表現獎 (2013年, 2018年)及香港浸會大學傑出研究指導獎(2024年),近年亦位列斯坦福大學全球Top 2%科學家榜單。
李教授的科研團隊發表了包括“Nature Communications”, “Autophagy”, “Signal Transduction and Targeted Therapy” ,“Aging Cell” 等在內的國際高水平學術研究論文近200篇,主持國家自然科學基金、香港研究資助局研究基金等多項研究課題。出版學術專著20余部,並獲得了超過20項美國、歐洲及中國專利。
Research Interests
Professor Li’s key research area:
- The relationship between autophagy regulation and neurodegenerative diseases such as Parkinson’s Disease (PD), Alzheimer’s Disease (AD), and Amyotrophic Lateral Sclerosis (ALS).
- The application of Traditional Chinese Medicine (TCM) in the prevention and treatment of neurodegenerative diseases.
- The identification of molecular targets from TCM for novel drug discovery in neurodegeneration.
- Investigating the efficacy and safety of TCM for conditions such as AD and PD, through randomised controlled clinical trials, whilst also exploring the interaction between TCM and Western medicine.
李教授的主要研究領域:
- 自噬調控與神經退行性疾病(如柏金遜症、阿茲海默症、肌萎縮側索硬化症)的關係。
- 中醫藥在預防及治療神經退行性疾病中的應用。
- 從中醫藥中發現用於治療神經退行性疾病的新藥分子靶點。
- 通過隨機對照臨床試驗,研究中醫藥治療神經退行性疾病(如阿茲海默症、柏金遜症)的療效與安全性,並探索中西醫藥物的相互作用。
Education/Academic qualification
-, PhD, PhD Program in Medicine, School of Medicine, Tokai University, Japan
1 Apr 1998 → 31 Mar 2001
Award Date: 31 Mar 2001
Master, Master Program of Chinese Medicine, Guangzhou University of Chinese Medicine
1 Sept 1985 → 30 Jun 1988
Award Date: 30 Jun 1988
Bachelor, Bachelor Program of Chinese Medicine , Henan University of Chinese Medicine
1 Sept 1980 → 31 Jul 1985
Award Date: 31 Jul 1985
Keywords
- RZ Other systems of medicine
- Internal medicine of Chinese medicine
- Neurodegenerative diseases
- Autophagy
- Neuropharmacology
- Parkinson's disease
- Alzheimer's disease
- Higher education in Chinese medicine
- Clinical study of Chinese medicine
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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Collaborations and top research areas from the last five years
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A novel mechanism of autophagy-lysosome pathway impairment in Alzheimer disease-associated neuropathogenesis: Role of AKAP11-mediated autophagy and PKA signaling
DENG, Z. (PI), Yue, Z. (CoI) & LI, M. (CoI)
1/01/26 → 31/12/28
Project: Research project
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基于TFEB介导的自噬通路探究AKAP11基因缺失导致精神分裂症的发病机制
DENG, Z. (PI), LI, M. (Collaborator), Kan , Y. (Collaborator), LIU, J. (Collaborator), GUAN, X. (Collaborator), LU, J. (Collaborator) & XU, X. (Collaborator)
1/01/26 → 31/12/28
Project: Research project
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外泌体介导的自噬诱导剂靶向神经元治疗阿尔茨海默病的临床前研究
LI, M. (PI), Ye, K. (CoPI), YANG, Z. (CoPI), DENG, Z. (CoPI) & IYASWAMY, A. (CoPI)
3/11/25 → 2/11/27
Project: Research project
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Investigating the mechanism of (-)Schisandrin B on the treatment of Parkinson's disease via regulating ATG16L1/NLRP3 signalling pathway
LI, M. (PI), Song, J.-X. (CoI), IYASWAMY, A. (CoI) & DENG, Z. (CoI)
9/10/24 → 8/10/27
Project: Research project
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DeepDrugDiscovery identifies blood–brain barrier permeable autophagy enhancers for Alzheimer’s disease
Dong, Y., Xiao, X., Zhuang, X. X., Wu, W., Wang, Z. Y., Zhang, S., Li, J. T., Zhang, K., Fu, W. Y., Chen, J. M., Xiong, S. H., Deng, S., Li, K., Ma, C., Jin, W., Jin, X., Cai, Q., Shen, H. M., Li, M. & Su, H. & 9 others, , 24 Apr 2026, (E-pub ahead of print) In: Nature Biomedical Engineering.Research output: Contribution to journal › Journal article › peer-review
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Development of an explainable machine learning model for predicting poststroke anxiety: A multicenter study using Shapley Additive Explanations and nomogram visualization
Lyu, M., Xie, Y., Li, M., Hölscher, C. & Shen, X., 8 Jan 2026, In: Digital Health. 12, 21 p.Research output: Contribution to journal › Journal article › peer-review
Open Access -
Electroacupuncture ameliorates tau-driven cognitive decline by modulating NF-κB/NLRP3 inflammasome signaling in P301S mice
Zheng, R., Liu, X., Liao, Z., Wan, R., Qiu, G., Li, M., Tang, C., Zhou, R. & Song, J., Apr 2026, In: Experimental Neurology. 398, 11 p., 115637.Research output: Contribution to journal › Journal article › peer-review
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Neurotoxic mechanisms of microplastic compounds in Alzheimer’s and Parkinson’s diseases: A network toxicology and molecular docking study
Sun, Z., Peng, J., Feng, Z., Wang, X., Long, H., Qi, S., Li, L., LI, M., Yung, K. K. L., Cheung, K.-H. & Zhang, Z., Aug 2026, In: Ecotoxicity and Environmental Safety. 321, 11 p., 120437.Research output: Contribution to journal › Journal article › peer-review
Open Access -
Schizophrenia and bipolar disorder risk gene AKAP11 sustains cognitive function by regulating TFEB-mediated autophagy
Deng, Z. (Co-first author), Kan, Y. (Co-first author), Liu, J., Ying, K. Y., Yang, Y., Guan, X., Xu, X., Su, C., Lu, J., Lu, K., Chen, Y., Krishnamoorthi, S., Lu, J., Iyaswamy, A., Cheung, K. H., Song, J., Yue, Z. & Li, M., 16 Jul 2026, (E-pub ahead of print) In: Cell Death and Differentiation.Research output: Contribution to journal › Journal article › peer-review
Prizes
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Best Poster Prize (“NRBF2 is involved in the degradation process of APP-CTFs in Alzheimer disease models”)
LI, M. (Recipient), 5 Sept 2017
Prize
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President’s Award for Outstanding Performance in Research Supervision
LI, M. (Recipient), 2 May 2024
Prize: Award
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Activities
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TFE3 deficiency aggravates tauopathy and impairs memory in mice involving CAPON accumulation
LI, M. (Speaker)
26 Mar 2023 → 29 Mar 2023Activity: Conference/talk/lecture/symposium/speech/workshop, etc › Event organized by non-HKBU units
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Corynoxine has neuroprotective effects in experimental Alzheimer’s disease models via TFEB/TFE3-mediated autophagy induction
LI, M. (Speaker)
26 Mar 2023 → 29 Mar 2023Activity: Conference/talk/lecture/symposium/speech/workshop, etc › Event organized by non-HKBU units
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Studying the mechanism of (-)Schisandrin B on the treatment of Parkinson's disease via ATG16L1/NLRP3 signaling pathway
LI, M. (Participant)
26 Mar 2023 → 29 Mar 2023Activity: Conference/talk/lecture/symposium/speech/workshop, etc › Event organized by non-HKBU units
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以中醫經典為導向的中醫臨床專科研修教學
LI, M. (Speaker)
28 Aug 2022Activity: Conference/talk/lecture/symposium/speech/workshop, etc › Event organized by non-HKBU units
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Targeting autophagy for novel Chinese medicine development for Parkinson’s disease treatment
LI, M. (Plenary/keynote speaker)
27 Aug 2022Activity: Conference/talk/lecture/symposium/speech/workshop, etc › Event organized by non-HKBU units
Press/Media
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HKBU develops versatile compound F-SLOH for Alzheimer’s disease treatment
24/08/22
1 item of Media coverage
Press/Media
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HKBU scientists develop versatile compound for treating Alzheimer’s disease
IYASWAMY, A., LI, M. & Wong, M. S.
24/08/22
1 Media contribution
Press/Media
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HKBU researchers invent Chinese medicine formula for Alzheimer’s disease
IYASWAMY, A. & LI, M.
3/02/21
1 Media contribution
Press/Media
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