King-Ho CHEUNG

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King-Ho CHEUNG, Dr

 https://orcid.org/0000-0001-8683-1654

Accepting PhD Students

20012024

Research activity per year

Personal profile

Chinese Name

張敬浩

Research Interests

Dr. Cheung is a locally trained scientist. He obtained his Bachelor Degree from The Hong Kong Polytechnic University in 1999 and PhD in Physiology from The Chinese University of Hong Kong in 2004. After that, he pursued his postdoctoral training in electrophysiology and calcium signaling at The University of Pennsylvania (Philadelphia, PA, USA) under the supervision of Prof. Kevin Foskett (2004-2010). 

In 2010, He took up the Assistant Professor position at the Department of Physiology, University of Hong Kong, and joined the School of Chinese Medicine, Hong Kong Baptist University in 2017 as the Associate Professor. Dr.Cheung's research focuses on the structure/function of ion channels and their roles in disease pathogenesis, particularly in Alzheimer's disease and Parkinson's disease. His work has been published in several top-ranked journals including Autophagy, Neuron, Cell, PNAS and Science Signaling.

Dr. Cheung's research interests are:

  • Structure-function of intracellular calcium release channels (inositol trisphosphate receptors, ryanodine receptors, and two-pore channel) and their roles in health and disease.
  • Molecular mechanisms for the pathogenesis of Alzheimer's disease and Parkinson's disease (calcium disruption and neuronal autophagy)
  • Development of pharmacological compounds from Chinese medicine for neurodogeneration therapy.

Biography

Working Experience

Date

Position

Institute

11/2023 - present

Executive Associate Dean of Graduate School

The Hong Kong Baptist University

2023 - present

Vincent V.C. Woo Endowed Associate Professor in Chinese Medicine

The Hong Kong Baptist University

2017 - present

Associate Professor

School of Chinese Medicine, The Hong Kong Baptist University

2015 – 2017

Assistant Professor

School of Biomedical Sciences, The University of Hong Kong

2010 – 2015

Assistant Professor

Department of Physiology, The University of Hong Kong

2004 – 2010

Post-doctoral Fellow

Department of Physiology, The University of Pennsylvania, Philadelphia, Pennsylvania, USA

1999 – 2000

Research Assistant

Department of Physiology, The Chinese University of Hong Kong

   

Education and Academic Qualifications

Date

Education/Training

Institute

2000 – 2004

Ph.D. in Physiology

Department of Physiology, The Chinese University of Hong Kong

1999 – 2000

B.Sc. (Hons) in Applied Biology with Biotechnology

Department of Applied Biology and Chemical Technology, The Polytechnic University of Hong Kong

Selected Publications

. Tong BCK, Huang SY, Wu AJ, Iyaswamy A, Ho OKY, Kong AHY, Sreenivasmurthy SG, Zhu Z, Su CF, Liu J, Song JX, Li M, and Cheung KH* (2022) Tetrandrine ameliorates cognitive deficits and mitigates tau aggregation in cell and animal models of tauopathies. J Biomed Sci 29:85(2022). https://doi.org/10.1186/s12929-022-00871-6. *Corresponding author.

2. Tong BCK, Wu AJ, Huang AS, Dong R, Malampati S, Iyaswamy A, Krishnamoorthi S, Sreenivasmurthy SG, Zhu Z, Su C, Liu J, Song J, Lu JH, Tan J, Pan W, Li M and Cheung KH* (2022) Lysosomal TPCN (two pore segment channel) inhibition ameliorates beta-amyloid pathology and mitigates memory impairment in Alzheimer disease. Autophagy 18: 624-642. *Corresponding author.

3. Zhu Z, Liu LF, Su CF, Liu J, Tong BCK, Iyaswamy A, Krishnamoorthi S, Sreenivasmurthy SG, Guan XJ, Kan YX, Xie WJ, Zhao CL, Cheung KH, Lu JH, Tan JQ, Zhang HJ, Song JX and Li M (2022) Corynoxine B derivative CB6 prevents Parkinsonian toxicity in mice by inducing PIK3C3 complex-dependent autophagy. Acta Pharmacologica Sinica. https://doi.org/10.1038/s41401-022-00871-0.

4. Yang CB, Liu J, Tong BCK, Wang ZY, Zhu Z, Su CF, Sreenivasmurthy SG, Wu JX, Iyaswamy A, Krishnamoorthi S, Huang SY, Cheung KH, Song JX, Tan JQ, Lu JH and Li M (2022) TFEB, a master regulator of autophagy and biogenesis, unexpectedly promotes apoptosis in response to the cyclopentenone prostaglandin 15d-PGJ2. Acta Pharmacologica Sinica 43: 1251-1263

5. Yang C, Su C, Iyaswamy A, Krishnamoorthi SK, Zhu Z, Yang S, Tong BC, Liu J, Sreenivasmurthy SG, Guan X, Kan Y, Wu AJ, Huang AS, Tan J, Cheung KH, Song J and Li M (2022) Celastrol enhances transcription factor EB (TFEB)-mediated autophagy and mitigates Tau pathology: Implications for Alzheimer's disease therapy. Acta Pharmaceutica Sinica B 12: 1707-1722

6. Sreenivasmurthy SG, Iyaswamy A, Krishnamoorthi S, Senapati S, Malampati S, Zhu Z, Su CF, Liu J, Guan XJ, Tong BCK, Cheung KH, Tan JQ, Lu JH, Durairajan SSK, Song JX and Li M (2022) Protopine promotes the proteasomal degradation of pathological tau in Alzheimer's disease models via HDAC6 inhibition. Phytomedicine 96: 153887

7. Iyaswamy A, Wang X, Krishnamoorthi S, Kaliamoorthy V, Sreenivasmurthy SG, Kumar Durairajan SS, Song JX, Tong BCK, Zhu Z, Su CF, Liu J, Cheung KH, Lu JH, Tan JQ, Li HW, Wong MS and Li M (2022) Theranostic F-SLOH mitigates Alzheimer's disease pathology involving TFEB and ameliorates cognitive functions in Alzheimer's disease models. Redox Biology 51: 102280

8. Iyaswamy A, Krishnamoorthi SK, Zhang H, Sreenivasmurthy SG, Zhu Z, Liu J, Su CF, Guan XJ, Wang ZY, Cheung KH, Song JX, Durairajan SSK and Li M (2021) Qingyangshen mitigates amyloid-β and Tau aggregate defects involving PPARα-TFEB activation in transgenic mice of Alzheimer's disease. Phytomedicine 91:153648.

9. Cai CZ, Yang C, Zhuang XX, Yuan NN, Wu MY, Tan JQ, Song JX, Cheung KH, Su H, Wang YT, Tang BS, Behrends C, Durairajan SSK, Yue Z, Li M and Lu JH (2021) NRBF2 is a RAB7 effector required for autophagosome maturation and mediates the association of APP-CTFs with active form of RAB7 for degradation. Autophagy 17: 1112-1130

10. Yang C, Zhu Z, Tong BCK, Iyaswamy A, Xie WJ, Zhu Y, Sreenivasmurthy SG, Senthilkumar K, Cheung KH, Song JX, Zhang HJ and Li M (2020) A stress response p38 MAP kinase inhibitor SB202190 promoted TFEB/TFE3-dependent autophagy and lysosomal biogenesis independent of p38. Redox Biology 32:101445

11. Wu AJ, Tong BCK, Huang AS, Li M and Cheung KH* (2020) Mitochondrial calcium signaling as a therapeutic target for alzheimer’s disease. Current Alzheimer Research 17: 329-343. *Corresponding author.

12. Wang Z, Yang C, Liu J, Tong BCK, Zhu Z, Malampati S, Sreenivasmurthy SG, Cheung KH, Iyaswamy A, Su C, Lu J, Song J and Li M (2020) A curcumin derivative activates TFEB and protects against parkinsonian neurotoxicity in vitro. International Journal of Molecular Sciences 21:1515

13. Song JX, Malampati S, Zeng Y, Durairajan SSK, Yang CB, Tong BCK, Iyaswamy A, Shang WB, Sreenivasmurthy SG, Zhu Z, Cheung KH, Lu JH, Tang C, Xu N and Li M (2020) A small molecule transcription factor EB activator ameliorates beta-amyloid precursor protein and Tau pathology in Alzheimer's disease models. Aging Cell 19: e13069.

14. Iyaswamy A, Krishnamoorthi SK, Song JX, Yang CB, Kaliyamoorthy V, Zhang H, Sreenivasmurthy SG, Malampati S, Wang ZY, Zhu Z, Tong BCK, Cheung KH, Lu JH, Durairajan SSK and Li M (2020) NeuroDefend, a novel Chinese medicine, attenuates amyloid-β and tau pathology in experimental Alzheimer's disease models. Journal of Food and Drug Analysis 28: 132-146.

15. Iyaswamy A, Krishnamoorthi SK, Liu YW, Song JX, Kammala AK, Sreenivasmurthy SG, Malampati S, Tong BCK, Selvarasu K, Cheung KH, Lu JH, Tan JQ, Huang CY, Durairajan SSK and Li M (2020) Yuan-Hu Zhi Tong Prescription Mitigates Tau Pathology and Alleviates Memory Deficiency in the Preclinical Models of Alzheimer’s Disease. Frontiers in Pharmacology 11: 584770.

16. Huang AS, Tong BCK, Wu AJ, Chen X, Sreenivasmurthy SG, Zhu Z, Liu J, Su C, Li M and Cheung KH* (2020) Rectifying attenuated store-operated calcium entry as a therapeutic approach for alzheimer’s disease. Current Alzheimer Research 17: 1071-1087. *Corresponding author.

17. Yang L, Gu W, Cheung KH, Yan L, Tong BCK, Jiang Y and Yang J (2018) InsP3R-SEC5 interaction on phagosomes modulates innate immunity to Candida albicans by promoting cytosolic Ca2+ elevation and TBK1 activity. BMC Biology 16: 46.

18. Tong BCK, Wu AJ, Li M and Cheung KH* (2018) Calcium signaling in Alzheimer's disease & therapies. Biochimica et Biophysica Acta - Molecular Cell Research 1865: 1745-1760. *Corresponding author.

19. Wang Q, Guo W, Hao B, Shi X, Lu Y, Wong CWM, Ma VWS, Yip TTC, Au JSK, Hao Q, Cheung KH, Wu W, Li GR and Yue J (2016) Mechanistic study of TRPM2-Ca2+-CAMK2-BECN1 signaling in oxidative stress-induced autophagy inhibition. Autophagy 12: 1340-1354

20. Tong BCK, Lee CSK, Cheng WH, Lai KO, Foskett JK and Cheung KH* (2016) Familial Alzheimer's disease-associated presenilin 1 mutants promote γ-secretase cleavage of STIM1 to impair store-operated Ca2+ entry. Science Signaling 9: ra89. *Corresponding author.

21. Toglia P, Cheung KH, Mak DOD and Ullah G (2016) Impaired mitochondrial function due to familial Alzheimer's disease-causing presenilins mutants via Ca2+ disruptions. Cell Calcium 59: 240-250.

22. Lee CSK, Tong BCK, Cheng CWH, Hung HCH and Cheung KH* (2016) Characterization of Two-Pore Channel 2 by Nuclear Membrane Electrophysiology. Scientific Reports 6: 20282. *Corresponding author.

23. Mak DOD, Cheung KH, Toglia P, Foskett JK and Ullah G (2015) Analyzing and Quantifying the Gain-of-Function Enhancement of IP3 Receptor Gating by Familial Alzheimer’s Disease-Causing Mutants in Presenilins. PLoS Computational Biology 11 e1004529

24. Hao Y, Chow AW, Yip WC, Li CH, Wan TF, Tong BC, Cheung KH, Chan WY, Chen Y, Cheng CH and Ko WH (2016) G protein-coupled estrogen receptor inhibits the P2Y receptor-mediated Ca2+ signaling pathway in human airway epithelia. Pflugers Archiv European Journal of Physiology 468: 1489-1503

25. Joseph JD, Peng Y, Mak DOD, Cheung KH, Vais H, Foskett K and Wei H (2014) General anesthetic isoflurane modulates inositol 1,4,5-trisphosphate receptor calcium channel opening. Anesthesiology 121: 528-537

26. Mak DOD, Vais H, Cheung KH and Foskett JK (2013) Patch-clamp electrophysiology of intracellular Ca2+ channels. Cold Spring Harbor Protocols 2013: 787-797

27. Mak DOD, Vais H, Cheung KH and Foskett JK (2013) Isolating nuclei from cultured cells for patch-clamp electrophysiology of intracellular Ca2+ channels. Cold Spring Harbor Protocols 2013: 880-884

28. Mak DOD, Vais H, Cheung KH and Foskett JK (2013) Nuclear patch-clamp electrophysiology of Ca2+ channels. Cold Spring Harbor Protocols 2013: 885-891

29. Ma Z, Siebert AP, Cheung KH, Lee RJ, Johnson B, Cohen AS, Vingtdeux V, Marambaud P and Foskett JK (2012) Calcium homeostasis modulator 1 (CALHM1) is the pore-forming subunit of an ion channel that mediates extracellular Ca2+ regulation of neuronal excitability. Proceedings of the National Academy of Sciences of the United States of America 109: E1963-E1971

30. Müller M, Cheung KH^ and Foskett JK (2011) Enhanced ROS generation mediated by alzheimer's disease presenilin regulation of InsP3R Ca2+ signaling. Antioxidants and Redox Signaling 14: 1225-1235. ^Co-first authors

31. Müller M, Cárdenas C, Mei L, Cheung KH and Foskett JK (2011) Constitutive cAMP response element binding protein (CREB) activation by Alzheimer's disease presenilin-driven inositol trisphosphate receptor (InsP3R) Ca2+ signaling. Proceedings of the National Academy of Sciences of the United States of America 108: 13293-13298

32. Cheung KH#, Mei L, Mak DOD, Hayashi I, Iwatsubo T, Kang DE and Foskett JK (2010) Gain-of-function enhancement of IP3receptor modal gating by familial Alzheimer's disease-linked presenilin mutants in human cells and mouse neurons. Science Signaling 3: ra22. #First author

33. Cárdenas C, Miller RA, Smith I, Bui T, Molgó J, Müller M, Vais H, Cheung KH, Yang J, Parker I, Thompson CB, Birnbaum MJ, Hallows KR and Foskett JK (2010) Essential Regulation of Cell Bioenergetics by Constitutive InsP3 Receptor Ca2+ Transfer to Mitochondria. Cell 142: 270-283

34. Cheung KH#, Shineman D, Müller M, Cárdenas C, Mei L, Yang J, Tomita T, Iwatsubo T, Lee VMY and Foskett JK (2008) Mechanism of Ca2+ Disruption in Alzheimer's Disease by Presenilin Regulation of InsP3 Receptor Channel Gating. Neuron 58: 871-883. #First author

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Keywords

  • QP Physiology
  • Cell signaling
  • Ion channel
  • Neurodegeneration
  • Alzheimer's disease
  • Parkinson's disease
  • RM Therapeutics. Pharmacology
  • Traditional Chinese Medicine
  • Translational research
  • Drug discovery

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View all 14 projects / grants
  • 61 Journal article
  • 5 Review article
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  • 1 Editor/reviewer for publications (incl. CDCF T61 Journal Editor)