Projects per year
Personal profile
Chinese Name
Biography
(i) Education
2000.9 – 2006.2 Ph.D. in Biophysics, University of Michigan, Ann Arbor, USA
2003.1 – 2005.4 Master in Science Education, University of Michigan, Ann Arbor, USA
1995.9 – 1999.6 Bachelor of Science in Physics, Sun Yat-sen University, China
(ii) Work Experience
2021.7 – present Assistant Dean (Student learning experience), Faculty of Science, Hong Kong Baptist University (HKBU).
2014.9 – present Associate Professor, Department of Physics, HKBU.
2016.9 – present Director, Centre for Quantitative Systems Biology, HKBU
2008.9 – 2014.8 Assistant Professor, Department of Physics, HKBU
2006.2 – 2008.8 Postdoctoral Fellow, Department of Systems Biology, Harvard Medical School, USA
Research Interests
My main research interest is bio-dynamics, i.e., elucidating how molecular machineries organized as pathways/networks act dynamically within and between interacting cell types to control physiological and pathological responses in complex cellular environments. My research is at the unique juncture of biophysics, cell biology, cancer pharmacology and immunology, integrating advanced cross-disciplinary insight, research methodologies and quantitative analysis to decipher dynamic control underlying anticancer drug response and immuno-oncology. My work has developed quantitative approaches that combine live-cell imaging with mathematical modelling of pathway/network dynamics to unravel the context-specific pathway control at the system level, and uncovered novel chemoresistance mechanism and new combinatorial drug targets towards development of more effective cancer treatment strategies. More recently, my research centers on the exciting frontiers of immuno-oncology, with a particular interest in understanding the rate-limiting kinetics underlying the interactions between tumor and key innate immune cells, such as Natural Killer cells and monocytes/macrophages, as well as the spatiotemporal regulations of these interactions in the three-dimensional (3D) tumor microenvironment.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
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Dynamic regulation of p53 signaling and chemoresistance in three-dimensional (3D) cancer models
SHI, J. (PI)
8/02/24 → 6/01/27
Project: Research project
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Antitumor dynamics of Natural Killer cell and its response to immune checkpoint inhibitors in 3D tumor organoid models
SHI, J. (PI)
1/01/22 → 31/12/26
Project: Research project
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Frontiers in Systems Biology: Network, Environment & Human Disease
SHI, J. (PI)
Project: Research project
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Dynamic Behaviors and Strategies of Natural Killer Cell Chemotaxis towards Distinct Cancer Targets
SHI, J. (PI)
1/01/22 → 31/12/24
Project: Research project
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High-resolution live-cell imaging system for quantifying long-term 3D dynamics of large tissue models and organisms
SHI, J. (PI), Lam, Y. W. (CoPI), Lei, D. (CoPI), Leung, S. Y. (CoPI), Park, H. (CoPI), Sun, H. (CoPI), Tsao, S. W. (CoPI), Wong, A. S. T. (CoPI), Wong, C. C. L. (CoPI), Yuen, K. W. Y. (CoPI) & ZHAO, Z. (CoPI)
1/06/18 → 30/11/21
Project: Research project
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Proteogenomic Profiling Reveals Small ORFs and Functional Microproteins in Activated T Cells
Yang, Y., Chen, C., Li, K., Zhang, Y., Chen, L., Shi, J., Mu, Q., Xu, Y. & Zhao, Q., 4 Feb 2025, (E-pub ahead of print) In: Molecular and Cellular Proteomics. 100914.Research output: Contribution to journal › Journal article › peer-review
Open Access -
Deep Learning–Based 3D Single-Cell Imaging Analysis Pipeline Enables Quantification of Cell–Cell Interaction Dynamics in the Tumor Microenvironment
Liu, B., Zhu, Y., Yang, Z., Yan, H. H. N., Leung, S. Y. & Shi, J., 15 Feb 2024, In: Cancer Research. 84, 4, p. 517-526 10 p.Research output: Contribution to journal › Journal article › peer-review
Open Access3 Citations (Scopus) -
A mitotic NADPH upsurge promotes chromosome segregation and tumour progression in aneuploid cancer cells
Cheng, A., Xu, T., You, W., Wang, T., Zhang, D., Guo, H., Zhang, H., Pan, X., Wang, Y., Liu, L., Zhang, K., Shi, J., Yao, X., Guo, J. & Yang, Z., Jul 2023, In: Nature Metabolism. 5, 7, p. 1141-1158 18 p.Research output: Contribution to journal › Journal article › peer-review
15 Citations (Scopus) -
Cytotoxic and chemotactic dynamics of NK cells quantified by live-cell imaging
Zhu, Y. & Shi, J., 16 Jan 2023, The Immunological Synapse Part A. Thomas, C. & Galluzzi, L. (eds.). 1st ed. San Diego: Academic Press Inc., p. 49-64 16 p. (Methods in Cell Biology; vol. 173).Research output: Chapter in book/report/conference proceeding › Chapter › peer-review
1 Citation (Scopus) -
A Multifunctional Nanoplatform Based on Graphene Quantum Dots-Cobalt Ferrite for Monitoring of Drug Delivery and Fluorescence/Magnetic Resonance Bimodal Cellular Imaging
Teng, Y., Yuan, S., Shi, J. & Pong, P. W. T., Oct 2022, In: Advanced NanoBiomed Research. 2, 10, 11 p., 2200044.Research output: Contribution to journal › Journal article › peer-review
Open Access14 Citations (Scopus)