Projects per year
Personal profile
Chinese Name
Biography
(i) Education
2000.9 – 2006.2 Ph.D. in Biophysics, University of Michigan, Ann Arbor, USA
2003.1 – 2005.4 Master in Science Education, University of Michigan, Ann Arbor, USA
1995.9 – 1999.6 Bachelor of Science in Physics, Sun Yat-sen University, China
(ii) Work Experience
2021.7 – present Assistant Dean (Student learning experience), Faculty of Science, Hong Kong Baptist University (HKBU).
2014.9 – present Associate Professor, Department of Physics, HKBU.
2016.9 – present Director, Centre for Quantitative Systems Biology, HKBU
2008.9 – 2014.8 Assistant Professor, Department of Physics, HKBU
2006.2 – 2008.8 Postdoctoral Fellow, Department of Systems Biology, Harvard Medical School, USA
Research Interests
My main research interest is bio-dynamics, i.e., elucidating how molecular machineries organized as pathways/networks act dynamically within and between interacting cell types to control physiological and pathological responses in complex cellular environments. My research is at the unique juncture of biophysics, cell biology, cancer pharmacology and immunology, integrating advanced cross-disciplinary insight, research methodologies and quantitative analysis to decipher dynamic control underlying anticancer drug response and immuno-oncology. My work has developed quantitative approaches that combine live-cell imaging with mathematical modelling of pathway/network dynamics to unravel the context-specific pathway control at the system level, and uncovered novel chemoresistance mechanism and new combinatorial drug targets towards development of more effective cancer treatment strategies. More recently, my research centers on the exciting frontiers of immuno-oncology, with a particular interest in understanding the rate-limiting kinetics underlying the interactions between tumor and key innate immune cells, such as Natural Killer cells and monocytes/macrophages, as well as the spatiotemporal regulations of these interactions in the three-dimensional (3D) tumor microenvironment.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
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Dynamic Behaviors and Strategies of Natural Killer Cell Chemotaxis towards Distinct Cancer Targets
1/01/22 → 31/12/24
Project: Research project
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Antitumor dynamics of Natural Killer cell and its response to immune checkpoint inhibitors in 3D tumor organoid models
1/01/22 → 31/12/26
Project: Research project
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Dynamic regulation of p53 signaling and chemoresistance in three-dimensional (3D) cancer models
8/02/24 → 6/01/27
Project: Research project
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High-resolution live-cell imaging system for quantifying long-term 3D dynamics of large tissue models and organisms
SHI, J., Lam, Y. W., Lei, D., Leung, S. Y., Park, H., Sun, H., Tsao, S. W., Wong, A. S. T., Wong, C. C. L., Yuen, K. W. Y. & ZHAO, Z.
1/06/18 → 30/11/21
Project: Research project
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Cytotoxic and chemotactic dynamics of NK cells quantified by live-cell imaging
Zhu, Y. & Shi, J., 16 Jan 2023, The Immunological Synapse Part A. Thomas, C. & Galluzzi, L. (eds.). 1st ed. San Diego: Academic Press Inc., p. 49-64 16 p. (Methods in Cell Biology; vol. 173).Research output: Chapter in book/report/conference proceeding › Chapter › peer-review
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A Selective β-Catenin-Metadherin/CEACAM1-CCL3 Axis Mediates Metastatic Heterogeneity upon Tumor-Macrophage Interaction
To, S. K. Y., Tang, M. K. S., Tong, Y., Zhang, J., Chan, K. K. L., Ip, P. P. C., Shi, J. & Wong, A. S. T., 3 Jun 2022, In: Advanced Science. 9, 16, 14 p., 2103230.Research output: Contribution to journal › Journal article › peer-review
Open Access5 Citations (Scopus) -
Aurora A–mediated pyruvate kinase M2 phosphorylation promotes biosynthesis with glycolytic metabolites and tumor cell cycle progression
Jiang, Y., Wang, T., Sheng, D., Han, C., Xu, T., Zhang, P., You, W., Fan, W., Zhang, Z., Jin, T., Duan, X., Yuan, X., Liu, X., Zhang, K., Ruan, K., Shi, J., Guo, J., Cheng, A. & Yang, Z., Nov 2022, In: Journal of Biological Chemistry. 298, 11, 11 p., 102561.Research output: Contribution to journal › Journal article › peer-review
Open Access3 Citations (Scopus) -
Single-cell analysis of p53 transitional dynamics unravels stimulus- and cell type-dependent signaling output motifs
Xie, J., Zhang, L., Liu, B., Liang, X. & Shi, J., 11 Apr 2022, In: BMC Biology. 20, 1, 14 p., 85.Research output: Contribution to journal › Journal article › peer-review
Open Access1 Citation (Scopus) -
Energy restriction causes metaphase delay and chromosome mis-segregation in cancer cells
Cheng, A., Jiang, Y., Wang, T., Yu, F., Ishrat, I., Zhang, D., Ji, X., Chen, M., Xiao, W., Li, Q., Zhang, K., Niu, G., Shi, J., Pan, Y., Yang, Z. & Guo, J., Jun 2021, In: Cell Cycle. 20, 12, p. 1195-1208 14 p.Research output: Contribution to journal › Journal article › peer-review
2 Citations (Scopus)