20042022

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Personal profile

Chinese Name

史珏

Biography

(i) Education

2000.9 – 2006.2  Ph.D. in Biophysics, University of Michigan, Ann Arbor, USA

2003.1 – 2005.4  Master in Science Education, University of Michigan, Ann Arbor, USA

1995.9 – 1999.6  Bachelor of Science in Physics, Sun Yat-sen University, China

 

(ii) Work Experience

2021.7 – present  Assistant Dean (Student learning experience), Faculty of Science, Hong Kong Baptist University (HKBU).

2014.9 – present  Associate Professor, Department of Physics, HKBU.

2016.9 – present  Director, Centre for Quantitative Systems Biology, HKBU

2008.9 – 2014.8  Assistant Professor, Department of Physics, HKBU

2006.2 – 2008.8  Postdoctoral Fellow, Department of Systems Biology, Harvard Medical School, USA

Research Interests

My main research interest is bio-dynamics, i.e., elucidating how molecular machineries organized as pathways/networks act dynamically within and between interacting cell types to control physiological and pathological responses in complex cellular environments. My research is at the unique juncture of biophysics, cell biology, cancer pharmacology and immunology, integrating advanced cross-disciplinary insight, research methodologies and quantitative analysis to decipher dynamic control underlying anticancer drug response and immuno-oncology. My work has developed quantitative approaches that combine live-cell imaging with mathematical modelling of pathway/network dynamics to unravel the context-specific pathway control at the system level, and uncovered novel chemoresistance mechanism and new combinatorial drug targets towards development of more effective cancer treatment strategies. More recently, my research centers on the exciting frontiers of immuno-oncology, with a particular interest in understanding the rate-limiting kinetics underlying the interactions between tumor and key innate immune cells, such as Natural Killer cells and monocytes/macrophages, as well as the spatiotemporal regulations of these interactions in the three-dimensional (3D) tumor microenvironment.

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

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Dive into the research topics where Jue SHI is active. Topic labels come from the works of this scholar.
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