Of his professional practice, he has maintained a highly successful career as a conductor, appearing regularly in concert halls across the globe including Carnegie Hall in New York, Glinka Cappella Hall in Russia and National Centre for the Performing Arts in Beijing. He has conducted such ensembles as Moscow State Philharmonic Orchestra, St. Petersburg State Capella Orchestra, Sudestdeutsche Philharmonie, Kammarkoren Svenska Roster, Kammerchor Stuttgart, Slezske Divadlo Opava, Opera Hong Kong, Sinfonica dell’ international Chamber Ensemble, New England Symphonic Ensemble, Taiwan Baroque Camerata, Xiamen Philharmonic Orchestra, Shenzhen Symphony Orchestra, and the Hong Kong Philharmonic Orchestra.  Previously, he held positions as Director of Opera at University of Evansville (USA), Music Director of Evansville Collegium Musicum (USA), Associate Conductor of OperaFestival di Roma (Italy) and Artistic Director of Harlaxton International Chamber Music Festival (UK).

During his 10-year service as Head of the Department of Music, Professor Poon has spearheaded major performance, research, curriculum and development projects, making the Department synonymous with quality in teaching and research. In addition to teaching and research, Professor Poon plays an indispensable role in capital works projects, in terms of fundraising and planning of physical spaces. Examples included the renovation of the Department of Music and its relocation to Sing Tao Building; new teaching and recording studios in David C. Lam Building; and now the design of the new Creative Hub in the Jockey Club Campus of Creativity to be completed in 2024. His contribution to HKBU extends beyond the departmental level, particularly by serving as Acting Dean of Arts and Convenor of the Creative Media/Practice Research Cluster.

Professor Poon serves in a number of committees and advisory boards, including Curriculum Development Committee on Key Learning Areas (Arts Education), Education Bureau; Programme and Development Committee of Leisure and Cultural Services Department; and Hong Kong Arts Development Council. He is Chairman of the Advisory Committee for the Division of Cultural and Creativity at United International College, Zhuhai, and Artistic Advisor of Macao Orchestra. He also serves on panels for various organisations, accreditation reviews and award schemes. He is an elected Fellow of the Hong Kong Academy of the Humanities.