Joshua KO, Dr

Research Output

Research output per year 1994 1994 1995 2009 2010 2014 2016 2023

• 58 Journal article
• 26 Conference article
• 13 Conference paper
• 10 Review article
• 6 More
  • 3 Chapter
  • 2 Conference proceeding
  • 1 Editorial

Research output per year

Research output per year

Search results

• 2010

  437 The synergistic antitumorigenic effects of vinblastine and total Astragalus saponins (AST) with reduced invasiveness of colon cancer cells

  Ko, K. S. J., Au Yeung, K. W. & Law, P. C., Nov 2010, In: European Journal of Cancer. 8, 7 Suppl, p. 138 1 p.

  Research output: Contribution to journal › Conference article › peer-review

• Astragalus saponins modulate mTOR and ERK signaling to promote apoptosis through the extrinsic pathway in HT-29 colon cancer cells

  AU YEUNG, K. K. W., Mok, N. L., Wong, C. M., Cho, C. H. & KO, J., Sept 2010, In: International Journal of Molecular Medicine. 26, 3, p. 341-349 9 p.

  Research output: Contribution to journal › Journal article › peer-review

  Open Access

  • Astragalus Membranaceus 100%
  • Colorectal Cancer Cells 100%
  • ERK Pathway 100%
  • Astragalus Saponins 100%
  • Promote Apoptosis 100%
  52 Citations (Scopus)

• Ginger extract and polaprezinc exert gastroprotective actions by anti-oxidant and growth factor modulating effects in rats

  Ko, J. K. & Leung, C. C., Dec 2010, In: Journal of Gastroenterology and Hepatology. 25, 12, p. 1861-1869 9 p.

  Research output: Contribution to journal › Journal article › peer-review

  • Antigrowth 100%
  • Growth Factors 100%
  • Ginger Extract 100%
  • Modulating Effect 100%
  • Antioxidant Factors 100%
  53 Citations (Scopus)

• Novel herbal flavonoids promote apoptosis but differentially induce cell cycle arrest in human colon cancer cell

  Auyeung, K.K.-W. & Ko, J.K.-S., Feb 2010, In: Investigational New Drugs. 28, 1, p. 1-13 13 p.

  Research output: Contribution to journal › Journal article › peer-review

  Open Access

  File

  • Flavonoids 100%
  • Herbal 100%
  • Cell Cycle Arrest 100%
  • Human Colon Cancer Cells 100%
  • Promote Apoptosis 100%
  77 Citations (Scopus)

  13 Downloads (Pure)

• Phytochemicals as modulators of PPARs and RXRs

  Ko, J. K., Lee, S. S. & Martin, H., 2010, In: PPAR Research. 407650.

  Research output: Contribution to journal › Editorial

  Open Access
  12 Citations (Scopus)
• 2009

  A novel anticancer effect of Astragalus saponins: Transcriptional activation of NSAID-activated gene

  Auyeung, K. K. W., Cho, C.-H. & Ko, J. K. S., 1 Sept 2009, In: International Journal of Cancer. 125, 5, p. 1082-1091 10 p.

  Research output: Contribution to journal › Journal article › peer-review

  • NAG-1 100%
  • Non-steroidal Anti-inflammatory Drugs (NSAIDs) 100%
  • Anticancer Effect 100%
  • Transcriptional Activation 100%
  • Astragalus Saponins 100%
  60 Citations (Scopus)

• Astragalus saponins induce apoptosis via an ERK-independent NF-κB signaling pathway in the human hepatocellular HepG2 cell line

  Au Yeung, K. K. W., Law, P. C. & Ko, J., 2009, In: International Journal of Molecular Medicine. 23, 2, p. 189-196 8 p.

  Research output: Contribution to journal › Journal article › peer-review

  Open Access

  • Induced Apoptosis 100%
  • Astragalus Saponins 100%
  • Nuclear factor-κB Pathway 100%
  • HepG2 Cell Line 100%
  • Saponin 100%
  53 Citations (Scopus)

• Coptis chinensis inhibits hepatocellular carcinoma cell growth through nonsteroidal anti-inflammatory drug-activated gene activation

  AU YEUNG, K. K. W. & KO, J., 2009, In: International Journal of Molecular Medicine. 24, 4, p. 571-577 7 p.

  Research output: Contribution to journal › Journal article › peer-review

  Open Access

  • Hepatocellular Carcinoma Cells 100%
  • Gene Activation 100%
  • NAG-1 100%
  • Non-steroidal Anti-inflammatory Drugs (NSAIDs) 100%
  • Coptis chinensis 100%
  58 Citations (Scopus)

• Profiling of the action mechanisms and molecular targets of novel chemotherapeutics derived from herbal source in gastrointestinal cancers

  Ko, J.K.-S., 22 Jun 2009.

  Research output: Contribution to conference › Conference paper › peer-review

• The protective action of radix Astragalus membranaceus against hapten-induced colitis through modulation of cytokines

  KO, J. & Chik, C. W. S., Aug 2009, In: Cytokine. 47, 2, p. 85-90 6 p.

  Research output: Contribution to journal › Journal article › peer-review

  • Astragalus Membranaceus 100%
  • Protective Behavior 100%
  • Colitis 100%
  • Radix Astragali 100%
  • Hapten 100%
  58 Citations (Scopus)
• 2008

  Astragalus saponins (AST) modulate mTOR and ERK signaling with NF-kappa B as target in native and cytokine-induced HT-29 colon cancer cells (Poster Abstract)

  Ko, J. K. S., Mok, N. L., Wong, C. M. & Auyeung, K. K. W., Oct 2008, In: European Journal of Cancer Supplements. 6, 12, p. 179-180 2 p.

  Research output: Contribution to journal › Conference article › peer-review

• Herbal (Astragalus) saponins inhibit HepG2 cell growth and promote apoptosis through NF-κB and ERK signaling (Abstract)

  Ko, J. & Au Yeung, K. K. W., 1 May 2008, Proceedings: AACR 99th Annual Meeting 2008. Vol. 68.

  Research output: Chapter in book/report/conference proceeding › Conference proceeding › peer-review

  Open Access

  • Herbal 100%
  • HepG2 Cells 100%
  • Nuclear factor-κB 100%
  • Astragalus Membranaceus 100%
  • Astragalus Saponins 100%

• Herbal isoprenols induce apoptosis in human colon cancer cells through transcriptional activation of PPARγ

  AU YEUNG, K. K. W., Liu, P. L., Chan, C., Wu, W. Y., Lee, S. S. T. & KO, J., Aug 2008, In: Cancer Investigation. 26, 7, p. 708-717 10 p.

  Research output: Contribution to journal › Journal article › peer-review

  • Herbal 100%
  • Induced Apoptosis 100%
  • Transcriptional Activation 100%
  • Peroxisome Proliferator-activated Receptor 100%
  • Human Colon Cancer Cells 100%
  28 Citations (Scopus)

• Radix Astragali extract as potential anti-carcinogenic agent: from pro-apoptotic activity to identification of molecular targets

  Ko, J.K.-S., 26 Sept 2008.

  Research output: Contribution to conference › Conference paper › peer-review
• 2007

  Astragalus saponins induce growth inhibition and apoptosis in human colon cancer cells and tumor xenograft

  Tin, M. M. Y., Cho, C.-H., Chan, K., James, A. E. & Ko, J. K. S., Jun 2007, In: Carcinogenesis. 28, 6, p. 1347-1355 9 p.

  Research output: Contribution to journal › Journal article › peer-review

  Open Access

  • Apoptosis 100%
  • Growth Inhibition 100%
  • Tumor Xenograft 100%
  • Astragalus Saponins 100%
  • Cancer Tumor 100%
  146 Citations (Scopus)

• Astragalus saponins induce transcriptional activation of NSAID-activated gene (NAG-1) in colon cancer cells via a PI3K-Akt/Egr-1 signaling pathway (Abstract)

  Ko, J. K., Auyeung, K. K., Tin, M. M. & Cho, C.-H., Apr 2007, In: Gastroenterology. 132, 4, Supplement 2, p. A423 1 p.

  Research output: Contribution to journal › Conference article › peer-review

  Open Access

• Herbal diterpenoids induce growth arrest and apoptosis in colon cancer cells with increased expression of the nonsteroidal anti-inflammatory drug-activated gene

  KO, J., Leung, W. C., Ho, W. K. & Chiu, P., 15 Mar 2007, In: European Journal of Pharmacology. 559, 1, p. 1-13 13 p.

  Research output: Contribution to journal › Journal article › peer-review

  • Herbal 100%
  • Apoptosis 100%
  • Colon Cancer Cells 100%
  • Non-steroidal Anti-inflammatory Drugs (NSAIDs) 100%
  • Growth Arrest 100%
  67 Citations (Scopus)
• 2006

  Astragalus saponins induce inhibition of cell proliferation in association with COX-independent overexpression of NAG-1 in colon cancer cells (Abstract)

  Ko, J.K.-S., Tin, M. M., Cho, C.-H. & Chan, K. K., Apr 2006, In: Gastroenterology. 130, 4, Suppl 2, p. A583 1 p.

  Research output: Contribution to journal › Conference article › peer-review

  Open Access

• Herbal diterpenoids pseudolaric acid B and triptolide induce growth arrest and apoptosis in colon cancer cells

  Ko, J.K.-S., 23 Nov 2006.

  Research output: Contribution to conference › Conference paper › peer-review

• The antitumorigenic potential of total saponins from radix Astragalus membranaceus as chemotherapeutic adjuvant in treating colon cancer (Abstract)

  Tin, M. M. Y., Cho, C. H. & Ko, J.K.-S., Jul 2006, In: Acta Pharmacologica Sinica. 27 (Suppl 1), p. 68 1 p.

  Research output: Contribution to journal › Conference article › peer-review

  Open Access
• 2005

  A comparative study of the antitumor effects of a novel herbal extract and 5-FU/oxaliplain in a colon tumor xenograft model

  Ko, J.K.-S., Cho, C.-H. & Chan, K. K., Apr 2005, In: Gastroenterology. 128, Supplement 2, Issue 4, p. A-178 1 p., S1245.

  Research output: Contribution to journal › Conference article › peer-review

  • Antitumor Effect 100%
  • 5-fluorouracil (5-FU) 100%
  • Herbal Extracts 100%
  • Tumor Xenograft Model 100%
  • Colon Tumor 100%

• Amelioration of experimental colitis by Astragalus membranaceus through anti-oxidation and inhibition of adhesion molecule synthesis

  Ko, J.K.-S., Lam, F.Y.-L. & Cheung, A.P.-L., 7 Oct 2005, In: World Journal of Gastroenterology. 11, 37, p. 5787-5794 8 p.

  Research output: Contribution to journal › Journal article › peer-review

  Open Access

  • Experimental Colitis 100%
  • Astragalus Membranaceus 100%
  • Molecular Synthesis 100%
  • Antioxidation 100%
  • Adhesion Molecules 100%
  82 Citations (Scopus)

• Herbal Medicines and Animal Models of Gastrointestinal Diseases

  Cho, C. H. & KO, J., 27 Jan 2005, Drug Discovery Handbook. John Wiley & Sons Ltd., p. 1013-1035 23 p.

  Research output: Chapter in book/report/conference proceeding › Chapter › peer-review
  3 Citations (Scopus)

• The diverse actions of nicotine and different extracted fractions from tobacco smoke against hapten-induced colitis in rats

  KO, J. & Cho, C. H., Sept 2005, In: Toxicological Sciences. 87, 1, p. 285-295 11 p.

  Research output: Contribution to journal › Journal article › peer-review

  Open Access

  • Nicotine 100%
  • Colitis 100%
  • Hapten 100%
  • Tobacco Smoke 100%
  • Ulcerative Colitis 50%
  17 Citations (Scopus)
• 2004

  Adaptive cytoprotection through modulation of nitric oxide in ethanol-evoked gastritis

  KO, J., Cho, C. H. & Lam, S. K., 1 Sept 2004, In: World Journal of Gastroenterology. 10, 17, p. 2503-2508 6 p.

  Research output: Contribution to journal › Journal article › peer-review

  Open Access

  • Ethanol 100%
  • Nitric Oxide 100%
  • Gastritis 100%
  • Adaptive Cytoprotection 100%
  • Mucous Membrane 100%
  34 Citations (Scopus)

• Amelioration of hapten-induced colitis by radix Astragalus membranaceus through modulation of cytokines

  Ko, J.K.-S., 15 Jun 2004, In: Toxicology and Applied Pharmacology. 197, 3, p. 344 1 p.

  Research output: Contribution to journal › Conference article › peer-review

• A preliminary study of the effects of Astragali Radix extract on apoptosis and immunomodulation in human colonic cancer cells (Abstract)

  Ko, J.K.-S., 21 Oct 2004, In: Journal of Leukocyte Biology. 76, Supplement, p. 56-57 2 p.

  Research output: Contribution to journal › Conference article › peer-review

• Perspective and clinical significance of eicosanoids in the digestive system

  Cho, C. H., Ko, J. K. S. & Koo, M. W. L., 23 Mar 2004, The Eicosanoids. Curtis-Prior, P. (ed.). London: John Wiley & Sons Ltd., p. 407-414 8 p.

  Research output: Chapter in book/report/conference proceeding › Chapter › peer-review

  • Digestive System 100%
  • Eicosanoids 100%
  • Clinical Significance 100%
  • Prostanoids 100%
  • Gastrointestinal 100%
• 2003

  A preliminary study of the immunomodulation by radix Angelica sinensis (Chinese danggui) and heparin in experimental colitis

  Ko, J.K.-S. & Cho, C.-H., Apr 2003, In: Gastroenterology. 124, 4 (Supplement 1), p. A494-A495 2 p.

  Research output: Contribution to journal › Conference article › peer-review

  • Immunomodulation 100%
  • Experimental Colitis 100%
  • Angelica Sinensis 100%
  • Danggui 100%
  • Heparin 100%
• 2002

  Biomolecular free radical toxicity, causes and prevention

  Ko, J.K.-S., Apr 2002, In: Biochimie. 84, 4, p. 349-351 3 p.

  Research output: Contribution to journal › Review article › peer-review

• Delineation of the protective action of zinc sulfate on ulcerative colitis in rats

  Luk, H. H., Ko, J., Fung, H. S. & Cho, C. H., 17 May 2002, In: European Journal of Pharmacology. 443, 1-3, p. 197-204 8 p.

  Research output: Contribution to journal › Journal article › peer-review

  • Zinc Sulfate 100%
  • Ulcerative Colitis 100%
  • Protective Behavior 100%
  • 4-dinitrobenzene 100%
  • Sulfonic Acid 100%
  72 Citations (Scopus)
• 2001

  Aggravating effect of cigarette smoke exposure on experimental colitis is associated with leukotriene B₄ and reactive oxygen metabolites

  Guo, X., Ko, J. K. S., Mei, Q. B. & Cho, C. H., Oct 2001, In: Digestion. 63, 3, p. 180-187 8 p.

  Research output: Contribution to journal › Journal article › peer-review

  • Trinitrobenzene Sulfonic Acid 100%
  • Experimental Colitis 100%
  • Reactive Oxygen Metabolites 100%
  • Leukotriene B4 (LTB4) 100%
  • Cigarette Smoke Exposure 100%
  26 Citations (Scopus)

• Beneficial intervention of experimental colitis by passive cigarette smoking through the modulation of cytokines in rats

  Ko, J.K.-S., Sham, N.-F., Guo, X. & Cho, C.-H., Jan 2001, In: Journal of Investigative Medicine. 49, 1, p. 21-29 9 p.

  Research output: Contribution to journal › Journal article › peer-review

  • Experimental Colitis 100%
  • Cigarette Smoking 100%
  • Cytokine 100%
  • Colitis 50%
  • 4-dinitrobenzene 37%
  32 Citations (Scopus)

• Protective role of cyclooxygenase inhibitors in the adverse action of passive cigarette smoking on the initiation of experimental colitis in rats

  Guo, X., Liu, E. S. L., Ko, J. K. S., Wong, B. C. Y., Ye, Y. N., Lam, S. K. & Cho, C. H., 5 Jan 2001, In: European Journal of Pharmacology. 411, 1-2, p. 193-203 11 p.

  Research output: Contribution to journal › Journal article › peer-review

  • Experimental Colitis 100%
  • Protective Behavior 100%
  • Cigarette Smoking 100%
  • Cyclooxygenase Inhibitors 100%
  • Cigarette Smoke Exposure 100%
  26 Citations (Scopus)
• 2000

  Adverse action of cigarette smoke exposure on experimental colitis is associated with reactive oxygen metabolites and leukotriene B4

  Guo, X., Ko, J.K.-S. & Cho, C.-H., Apr 2000, In: Gastroenterology. 118, 4 (Part 1), p. A345 1 p.

  Research output: Contribution to journal › Conference article › peer-review

  • Experimental Colitis 100%
  • Reactive Oxygen Metabolites 100%
  • Leukotriene B4 (LTB4) 100%
  • Cigarette Smoke Exposure 100%
  • Adverse Action 100%

• Alcohol drinking and cigarette smoking: A "partner" for gastric ulceration

  Ko, J. K. S. & Cho, C. H., Dec 2000, In: Chinese Medical Journal (Taipei). 63, 12, p. 845-854 10 p.

  Research output: Contribution to journal › Review article › peer-review

  • Cigarette Smoking 100%
  • Gastric Ulcer 100%
  • Alcohol Drinking 100%
  • Stomach Ulcer 100%
  • Drinking Behavior 100%
  49 Citations (Scopus)

• Immunoregulation of colonic cytokine mRNA expression by passive cigarette smoking and red wine consumption in experimentally induced colitis rats

  Ko, J.K.-S., Sham, N. F., Guo, X. & Cho, C.-H., Apr 2000, In: Gastroenterology. 118, 4 (Part 2), p. A1352 1 p.

  Research output: Contribution to journal › Conference article › peer-review

  • Colitis 100%
  • Cigarette Smoking 100%
  • Immunoregulation 100%
  • Red Wine Consumption 100%
  • Cytokine mRNA Expression 100%

• The accelerated healing effects of passive cigarette smoking and nicotine on DNBS-induced colitis through the inhibition of neutrophil-derived free radicals

  Sham, N. F., Ko, J.K.-S. & Cho, C.-H., Apr 2000, In: Gastroenterology. 118, 4 (Part 1), p. A577 1 p., 3009.

  Research output: Contribution to journal › Conference article › peer-review

  • Acid Activation 100%
  • Free Radicals 100%
  • Nicotine 100%
  • Colitis 100%
  • 4-dinitrobenzene 100%
• 1999

  Involvement of neutrophils and free radicals in the potentiating effects of passive cigarette smoking on inflammatory bowel disease in rats

  Guo, X., Wang, W. O., Ko, J. K. S. & Cho, C. H., Oct 1999, In: Gastroenterology. 117, 4, p. 884-892 9 p.

  Research output: Contribution to journal › Journal article › peer-review

  • Inflammatory Bowel Disease 100%
  • Free Radicals 100%
  • Neutrophils 100%
  • Potentiating Effect 100%
  • Cigarette Smoking 100%
  89 Citations (Scopus)

• The therapeutic intervention of hapten (DNBS) induced ulcerative colitis by passive cigarette smoking in rats

  Ko, J.K.-S., Guo, X. & Cho, C. H., Apr 1999, In: Gastroenterology. 116, 4 (Suppl), p. A750 1 p.

  Research output: Contribution to journal › Conference article › peer-review
• 1998

  Histological Study of Mechanisms of Adaptive Cytoprotection on Ethanol-Induced Mucosal Damage in Rat Stomachs

  Ko, J. K. S. & Cho, C. H., Jun 1998, In: Digestive Diseases and Sciences. 43, 6, p. 1248-1257 10 p.

  Research output: Contribution to journal › Journal article › peer-review

  • Mucus 100%
  • Mucosal Damage 100%
  • Adaptive Cytoprotection 100%
  • Ethanol-induced Liver Injury 100%
  • Histological Study 100%
  8 Citations (Scopus)

• The correlation of the weakening effect on gastric mucosal integrity by 5-HT with neutrophil activation

  Ko, J. K. S., Ma, J.-J., Chow, J. Y. C., Ma, L. & Cho, C.-H., Apr 1998, In: Free Radical Biology and Medicine. 24, 6, p. 1007-1014 8 p.

  Research output: Contribution to journal › Journal article › peer-review

  • Mucosal Integrity 100%
  • 5-hydroxytryptamine 100%
  • Neutrophil Activation 100%
  • Gastric mucosal 100%
  • Weakening Effect 100%
  5 Citations (Scopus)
• 1997

  Co-regulation of mucosal prostanoids and substance P by indomethacin in rat stomachs

  Ko, J. K. S., Tang, F. & Cho, C. H., 4 Apr 1997, In: Life Sciences. 60, 19, p. PL277-PL281

  Research output: Contribution to journal › Journal article › peer-review

  • Substance P 100%
  • Indomethacin 100%
  • Prostanoids 100%
  • Rat Stomach 100%
  • Co-regulation 100%
  7 Citations (Scopus)

• The vascular and glandular organoprotective properties of metronidazole in the rodent stomach

  Ko, J. K. S., Ching, C. K., Chow, J. Y. C., Zhang, S. T., Lam, S. K. & Cho, C. H., Jul 1997, In: Alimentary Pharmacology and Therapeutics. 11, 4, p. 811-819 9 p.

  Research output: Contribution to journal › Journal article › peer-review

  Open Access

  • Rodents 100%
  • Metronidazole 100%
  • Stomach 100%
  • Ethanol 44%
  • Incubation 22%
  3 Citations (Scopus)
• 1996

  Adaptive gastric mucosal cytoprotection in rats: Different modes of action by three mild irritants

  Ko, J. K. S. & Cho, C. H., 1 Jan 1996, In: Digestion. 57, 1, p. 54-59 6 p.

  Research output: Contribution to journal › Journal article › peer-review

  • Ethanol 100%
  • Mode of Action 100%
  • Cytoprotection 100%
  • Irritant 100%
  • Gastric mucosal 100%
  5 Citations (Scopus)

• Mucosal nitric oxide is not responsible for the hemodynamic changes induced by nicotine in rat stomachs

  Wong, D., Qiu, B. S., Ko, J. K. S., Koo, M. W. L. & Cho, C. H., 15 May 1996, In: Environmental Toxicology and Pharmacology. 1, 3, p. 167-174 8 p.

  Research output: Contribution to journal › Journal article › peer-review

  • Nitric Oxide 100%
  • Nicotine 100%
  • Hemodynamic Changes 100%
  • L-NAME 100%
  • Rat Stomach 100%

• The antilesion actions of anticholinergic agents on ethanol-induced injury in rat stomachs: The importance of gastric vascular integrity and tonicity

  Ko, J. K. S. & Cho, C. H., 1996, In: Journal of Autonomic Pharmacology. 16, 3, p. 117-124 8 p.

  Research output: Contribution to journal › Journal article › peer-review

  • Atropine 100%
  • Tonicity 100%
  • Ethanol-induced Liver Injury 100%
  • Rat Stomach 100%
  • Vascular Integrity 100%
  7 Citations (Scopus)
• 1995

  Contributions of physical and chemical properties of mild irritants to gastric cytoprotection in rats

  Ko, J. K. S., Cho, C. H., Lam, S. K., Koo, M. W. L. & Ching, C. K., 26 May 1995, In: Life Sciences. 57, 1, p. PL13-PL18 6 p.

  Research output: Contribution to journal › Journal article › peer-review

  • Ethanol 100%
  • Physical Properties 100%
  • Chemical Properties 100%
  • Irritant 100%
  • Gastric Cytoprotection 100%
  7 Citations (Scopus)

• Felodipine-and ethanol-lnduced gastric mucosal damage in rats

  Liu, X. G., Cho, C. H. & Ko, J. K. S., 1995, In: Pharmacology. 51, 6, p. 391-397 7 p.

  Research output: Contribution to journal › Journal article › peer-review

  • Ethanol 100%
  • Gastric mucosal Injury 100%
  • Felodipine 100%
  • Gastric mucosal Blood Flow 66%
  • Ulcer 50%
  2 Citations (Scopus)

• Leucocyte‐endothelial interactions in the vasculature following inflammation of the gastric mucosa

  KO, J. & CHO, C., Aug 1995, In: Journal of Gastroenterology and Hepatology. 10, 4, p. 469-470 2 p.

  Research output: Contribution to journal › Journal article › peer-review
  1 Citation (Scopus)