I have expertise in the fields of pharmacology, toxicology, chemotherapy and gastroenterology. My research focuses on investigating novel signaling pathways and oncogenic biomarkers associated with gastrointestinal cancers including that of the pancreas, colon, liver and stomach, with the aim to identify molecular drug targets and exploring potential anticancer phytochemicals and functional peptides. One of my research milestones was to decipher the roadmap for anticarcinogenic mechanisms carried out by a special Astragalus saponins extract (AST) during its comprehensive bioactive activities when treating a panel of cancers (American Journal of Chinese Medicine 44(1):1-22, 2016). Currently, I am actively studying the molecular mechanism of two novel isoflavonoids on their anticancer potential via modulation of different variants of autophagy as well as the tumor microenvironment as neoadjuvants in pancreatic cancer therapy, together with their ability to alleviate chemoresistance in cancer cells (Antioxidants 11:1349, 2022; Phytomedicine 106:154406, 2022). New ventures include the use of tumor-targeting functional peptides and establishment of DNA vaccines or nanoparticles to improve drug delivery to tumor cells.

我的專業領域包括藥理學、毒理學、癌病化療和胃腸病學。我的研究重點是探討胃腸道癌症（包括胰腺癌、結腸癌、肝癌和胃癌）的信號通路和致癌生物標誌物，特別關注識別關鍵的分子藥物靶點，探索潛在的抗癌植物化學物質及其潛在機制。我的研究里程碑之一是闡明了黃耆總皂苷萃取物（AST）在一系列人類癌症中的抗癌活性綜合路線圖（美國中醫雜誌 44(1):1-22, 2016）。目前，我正在積極研究兩種新型異黃酮類化合物透過調控各種自噬過程和腫瘤微環境在胰臟癌化療中的分子機制（抗氧化劑 11:1349, 2022；植物藥 106:154406, 2022）。新的項目包括使用腫瘤靶向功能勝肽和建立奈米顆粒/DNA疫苗來提高癌細胞中藥物輸送的精確度，旨在提高化療效果並防止化學抗藥性。