Personal profile
Chinese Name
Biography
Dr Allen Cheung's PhD work involved identifying a unique subset of viral genes expressed by human cytomegalovirus latent infection of CD34+ hematopoietic myeloid progenitor cells using viral custom-made microarrays. One of these genes (UL111A/viral homolog of humanIL-10) downregulates MHC class II molecules to prevent T cell recognition; these work resulted in two publications in Blood.
In his postdoc in Tokyo, he was involved in delineating the mechanism by which T cells produce IFN-γ following IL-12/STAT4 stimulation. During his time in HKU, he was involved in solving the underlying mechanism of two novel vaccines (J Clin Invest and Mol Therapy), as well as the interplay between CMV and HIV co-infection in CD34+ stem cells (Blood Advances). Moreover, I identified and characterised a novel PD-1 isoform (Delta42PD1) and found its cognate receptor to be TLR4, which underlie gut inflammation during acute HIV-1 infection (Nature Microbiology).
Research Interests
- Novel immunological protein Δ42PD1 and its role in inflammatory diseases
- Human cytomegalovirus (HCMV) latent infection in CD34+ stem cells and associated diseases
Fingerprint
- 1 Similar Scholars
Collaborations and top research areas from the last five years
-
Defining the mechanism by which Vgamma9Vdelta2 T cells induce pyroptosis in pleural mesothelioma and combination immunotherapy with CD8+ T cells
CHEUNG, K. L. A. (PI) & LUNG, H. L. (CoI)
1/01/26 → 31/12/27
Project: Research project
-
Translating Disease-Mechanism Discoveries to Improve Treatment of Biliary Atresia, an Intractable Newborn Liver Disease
Lui, V. C. (PI), CHEUNG, K. L. A. (CoPI), Tam, P. K. H. (CoPI), De Coppi , P. (CoPI), Lendahl , U. (CoPI), Sampaziotis , F. (CoPI), Sham, P. C. (CoPI), Wong, I. C. K. (CoPI), Wong, K. K. Y. (CoPI), Yip , K. Y. L. (CoPI), Cheah, K. S. E. (CoPI), Chung, B. H. Y. (CoPI), Chung, P. H. Y. (CoPI), Li , L. (CoPI), O'Callaghan , C. (CoPI), Rowitch , D. (CoPI), Tang , C. S. M. (CoPI), Bin , W. (CoPI), Davenport, M. (CoPI), Jenkins , D. (CoPI), Mitchison , H. (CoPI), Elvassore , N. (CoPI), Vallier , L. (CoPI) & Zhang, M. (CoPI)
1/01/22 → 31/12/26
Project: Research project
-
Equipment Matching Fund - Desktop Scanning Electron Microscope (Desktop SEM)
QIU, J. (PI), CHIU, M. Y. (CoI), CHEUNG, K. L. A. (CoI), ZHAO, Z. (CoI), LIAO, P. (CoI) & ZHAO, J. (CoI)
26/03/24 → 25/03/26
Project: Research project
-
Gamma-delta T cells as immunotherapy against mesothelioma
CHEUNG, K. L. A. (PI)
1/05/21 → 3/07/24
Project: Research project
-
Viral Inhibition of Pseudo-SARS-CoV-2 Using a UV-C Equipped Ventilation Pipe
CHEUNG, K. L. A. (PI)
16/03/21 → 15/06/21
Project: Research project
-
HCMV infection disrupts barrier functions and promotes epithelial–mesenchymal transition in a cholangiocyte organoid model
Ye, Z. (Co-first author), Hu, X. (Co-first author), Rahaman, S. M., Zheng, Y., Zhang, X., Tang, C. S. M., Yau, T. M., Lee, W. K., Chung, P. H. Y., Wong, K. K. Y., Tam, P. K. H., Lui, V. C. H. & Cheung, A. K. L., 3 Feb 2026, In: Nature Communications. 17, 1, 21 p., 2273.Research output: Contribution to journal › Journal article › peer-review
Open Access -
Extracellular Silica Nanomatrices Promote In Vitro Maturation of Anti-tumor Dendritic Cells via Activation of Focal Adhesion Kinase
Tam, S. W., Cheung, K. L. A., Qin, P., Zhang, S., Huang, Z. & Yung, K. L., 15 Jan 2025, In: Advanced Materials. 37, 2, 16 p., 2314358.Research output: Contribution to journal › Journal article › peer-review
Open Access7 Citations (Scopus) -
Human cytomegalovirus latent genes facilitating human immunodeficiency virus type 1 coinfection in CD34+ cells: abridged secondary publication
Lee, W. K., Ye, Z., Cheung, A. K. L., Chen, Z. & Wang, H., 1 Jun 2025, In: Hong Kong Medical Journal. 31, 3, Supplement 3, p. S36-S39 4 p.Research output: Contribution to journal › Journal article › peer-review
Open Access -
Latent Human Cytomegalovirus Infection Activates the STING Pathway but p-IRF3 Translocation Is Limited
Lee, W. K., Ye, Z. & Cheung, A. K. L., 12 Aug 2025, In: Viruses. 17, 8, 20 p., 1109.Research output: Contribution to journal › Journal article › peer-review
Open Access -
Microneedles with an anisotropic porous microstructure facilitate the transdermal delivery of small molecules, lipid nanoparticles, and T cells
Hu, T., Lui, K. S., Ko, E. B., Zhao, Y., Zhang, Q., Yang, H., Zheng, M., Chang, H., Guo, B., Cheung, A. K. L. & Xu, C., 2 Apr 2025, In: Matter. 8, 4, 19 p., 102038.Research output: Contribution to journal › Journal article › peer-review
Open Access13 Citations (Scopus)